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    PEMICU 3 BLOK

    HEMATOLOGI

    Jessica 405100080 Borok ya! Tak K"#"! $e%&"'

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    LO 1(LEUKOPOE$I$

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    Maturation Sequences: Myeloid SeriesMaturation Sequences: Myeloid Series

    Mye)o&)as*Mye)o&)as*

     

    Pro%ye)ocy*ePro%ye)ocy*e

    Mye)ocy*eMye)ocy*e

    Me*a%ye)ocy*eMe*a%ye)ocy*e

    Ba+Ba+

    ,e"*ro-'i),e"*ro-'i)

    Cell size

     Cytoplasm color, volume,

    granulation

    Nucleus size, color,

    chromatin pattern

    Nucleoli presence

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    Mye)o&)as*s

    Graphic accessed http://www.wadsworth.org/chemheme/heme/glass/cytopix/slide03!lastsauer."pg, #$$%.

    http://www.wadsworth.org/chemheme/heme/glass/cytopix/slide036blastsauer.jpg http://www.wadsworth.org/chemheme/heme/glass/cytopix/slide036blastsauer.jpg

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    Mye)o&)as* .s Pro%ye)ocy*e

    Primary Granules [rich in myeloperoxidase]!

    N:C slightly decreased.

    &'() *+

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    Pro%ye)ocy*e

    Graphic accessed http://mmserver.c"p.com/images/image/300#$."pg, &000.

    http://mmserver.cjp.com/images/image/4304019.jpg http://mmserver.cjp.com/images/image/4304019.jpg

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    Pro%ye)ocy*e

    Graphic accessed http://www.vet.uga.edu/vpp/cler-/e-man/ig3."pg, &000.

    http://www.vet.uga.edu/vpp/clerk/ekman/Fig3.jpg http://www.vet.uga.edu/vpp/clerk/ekman/Fig3.jpg

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    Myelocyte s Promyelocyte

    "sence o# nucleoli!

    Secondary granules [lyso$yme]! Cytoplasm pin%ish&"lue '(a)n o# neutrophilia*

    N:C noticea"ly decreased.

    #0'&0) *+

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    Mye)ocy*e

    Graphic accessed http://www.med'ed.virginia.edu/courses/path/innes/images/nh"peg/nh)&0myelocyte)&0x#00."peg , &00#.

    http://www.med-ed.virginia.edu/courses/path/innes/images/nhjpeg/nh%20myelocyte%20x100.jpeg http://www.med-ed.virginia.edu/courses/path/innes/images/nhjpeg/nh%20myelocyte%20x100.jpeg

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    Mye)ocy*e

    Graphic accessed http://www.wadsworth.org/chemheme/heme/microscope/pix/myelocytenw."pg, &000.

    http://www.wadsworth.org/chemheme/heme/microscope/pix/myelocyte_nw.jpg http://www.wadsworth.org/chemheme/heme/microscope/pix/myelocyte_nw.jpg

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    Metamyelocyte vs Myelocyte

    #('30) *+

    / +lat&sided or indented nucleus!

    / Cytoplasm is uni#ormly pin% )ith eenly distri"uted

    pin%ish&purple secondary granules.

    / No nucleoli

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    Me*a%ye)ocy*e

    Graphic accessed http://www.med'ed.virginia.edu/courses/path/innes/nh/wc!maturation.cm, &000.

    http://www.med-ed.virginia.edu/courses/path/innes/nh/wcbmaturation.cfm http://www.med-ed.virginia.edu/courses/path/innes/nh/wcbmaturation.cfm

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     ,and s Metamyelocyte

    Nuclear indentation in "and is -/0 the )idth

    o# the hypothetical ROUND nucleus.

    1# you are going to err do so on the side o#

    maturity!

    #0'0) *+

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    Ba+

    Graphic accessed http://www.med'ed.virginia.edu/courses/path/innes/nh/wc!maturation.cm, &000.

    http://www.med-ed.virginia.edu/courses/path/innes/nh/wcbmaturation.cfm http://www.med-ed.virginia.edu/courses/path/innes/nh/wcbmaturation.cfm

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    PMN s ,N(

    #0'30) *+

    /1istinct lo!es connected !y chromatin strand 2no visi!le

    parachromatin

    /&'( lo!es 4normally5 possi!le

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    http://www accuspeedy com tw/70# picture mt/!lood)&0cell/w!c monocyte/0# entrypicture/8romono "pg

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    Moocy*es  Macro-'a!es

    / Moo-oiesis occ"rs i

    BM

    / Moocy*es -ro+"ce+ &y

    GM2C$ M2C$  IL23

    / Moocy*es *rasor%

    i*o %acro-'a!es i

    *'e *iss"es

    Graphics accessed http://www.med'ed.virginia.edu/courses/path/innes/nh/wc!maturation.cm 6 http://www.accuspeedy.com.tw/70#picturemt/!lood)&0cell/w!cmonocyte/0#entrypicture/+ono!last."pg

    &000

    http://www.accuspeedy.com.tw/70#picturemt/!lood)&0cell/w!cmonocyte/0#entrypicture/8romono."pg

    http://www.med-ed.virginia.edu/courses/path/innes/nh/wcbmaturation.cfm http://www.med-ed.virginia.edu/courses/path/innes/nh/wcbmaturation.cfm http://www.med-ed.virginia.edu/courses/path/innes/nh/wcbmaturation.cfm http://www.med-ed.virginia.edu/courses/path/innes/nh/wcbmaturation.cfm

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    Monocytes s 2ymphocytesMonocytes s 2ymphocytes

    •Cell size monocyte generally larger

    •Nuclear shape amorphous, indented vs round'oval

    •Nuclear color light'staining vs dar-'staining

    •Chromatin 4clumped5 vs ine lacy

    •Cytoplasm color light clear s-y'!lue vs gray'!lue

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    LO 6(Me#e)aska Le"kosi*

    / a. Neutro#il

    / ,e"*roi) a+a)a' !aris -er*a'aa -er*a%a *"&"' *er'a+a- i.asi o)e' &ak*eri sa!a* a!osi*ik +a sa!a* ak*i $e)2se) ii sa%-ai +i #ari!a *erieksi "*"k %eyera! +a %e!'ac"rka &ak*eri .ir"s a*a" a!e -eye&a& ieksi )aiya

    / ,e"*roi) %e%-"yai i*i se) ya! &era!kai +a ka+a!2ka+a! se-er*i *er-isa'2 -isa' -ro*o-)as%aya &ayak &i*ik2&i*ik 'a)"s 7!ra")a Gra")a e"*roi) %e%-"yai aii*as se+iki* *er'a+a- 9a* :ara &asa +a %e%&eri :ara &ir" a*a" %era' %"+a -"ca* ya! +ike)i)i!i o)e' si*o-)as%a ya! &er:ara %era' %"+a

    / ,e"*roi) %er"-aka )e"kosi* !ra")ar ya! -a)i! &ayak %eca-ai ;0< +ari #"%)a' se) +ara' -"*i' ,e"*roi) %er"-aka se) &er"%"r -e+ek +e!a :ak*" -ar"' +a)a% +ara' ;2= #a% +a #a!ka 'i+"- a*ara 124 'ari +a)a% #ari!a ika* se*e)a' i*" e"*roi) %a*i

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    / & Eosioi)

    / Eosioi) %er"-aka a!osi*ik ya! )e%a' J"%)a'ya aka

    %ei!ka* saa* *er#a+i a)er!i a*a"-eyaki* -arasi* Eosioi) %e%i)iki !ra")a si*o-)as%a ya! kasar +a &esar $e) !ra")aya &er:ara %era' sa%-ai %era'  #i!!a 7!a%&ar 64 'a-"sa s"%s"% *")a! +e!a -er&esara 1000>

    / Eosioi) %e%as"ki +ara' +ari s"%s"% *")a! +a &ere+ar 'aya ;210 #a% se&e)"% &er%i!rasi ke +a)a% #ari!a ika* *e%-a* eosioi) %e!'a&iska sisa 8216 'ari +ari #a!ka 'i+"-ya?a)a% +ara' or%a) eosioi) #a"' )e&i' se+iki* +ari e"*roi) 'aya 624< +ari #"%)a' se) +ara' -"*i'

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    / c Basoi)

    / Basoi) a+a)a' #eis )e"kosi* ya!-a)i! se+iki* #"%)a'ya yai*" k"ra! +ari 1< +ari #"%)a' se) +ara' -"*i' Basoi) %e%i)iki se#"%)a' !ra")a si*o-)as%a ya! &e*"kya *i+ak &era*"ra +a &er:ara ke"!"a sa%-ai 'i*a% 7!a%&ar 65 'a-"sa s"%s"%

    *")a! +e!a -er&esara 1000> / Basoi) %e%i)iki "!si %eyer"-ai

    se) %as* %e!a+"! 'is*a%i "*"k %ei!ka*ka a)ira +ara' ke #ari!a ya! ce+era +a 'e-ari "*"k %e%&a*" %ece!a' -e%&ek"a +ara'

    i*ra.ask")ar

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    / a. 2im#osit

    / Li%osi* a+a)a' !o)o!a )e"kosi*

    ke+"a *er&ayak se*e)a' e"*roi)&erkisar 60235< +ari se) +ara' -"*i' %e%i)iki "!si +a)a% reaksi i%"i*asLi%osi* %e%i)iki i*i ya! &")a* a*a" o.a) ya! +ike)i)i!i o)e' -i!!ira si*o-)as%a ya! se%-i* &er:ara &ir"

    / Ter+a-a* +"a #eis )i%osi* yai*" )i%osi* T +a )i%osi* B Li%osi* T

    &er!a*"! *i%"s &er"%"r -a#a! +i&e*"k +a)a% *i%"s Li%osi* B *i+ak &er!a*"! *i%"s *erse&ar +a)a% o)ike)2o)ike) ke)e#ar !e*a' &ei! Li%osi* T &e