neuro trans.ppt
TRANSCRIPT
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NEUROTRANSMITTERM.Azhari.
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Def : Neurotransmitter adalah zat kimia yang disintesa oleh sel-
sel saraf (sitoplasma terminal), yang disimpan pada
vesikel-vesikel ujung saraf pada terminal button
(bouton terminaux) atau axon terminale.
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Presinaptic neuronPostsinaptic neuron
Neuron yang menghasilkan Ach neuron cholinergicBerperan penting sebagai neurotransmisi serabut saraf motorik
dan motorik
Nt, release
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slower, longer-lasting effects
binding of Nts with receptoractivates G protein in membrane works through
cyclic AMP (cAMP) to:
regulate ion channels (open or close)
activate kinase enzymes within cytoplasm (activate proteins in cytoplasm)
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Animations, Ach bind to receptorion channel open
membran
Extra cell
Intra cell
Response
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Klasifikasi danfungsi
Transmitter group Transmitter compound function
Acetylcholin Acetylcholine (Ach) Exitatory and
inhibitory
neuromuscular,
neuroglandular
transmission
Involved in memory
Muscle contraction
Amino acid
Gamma-aminobutyric acid
(GaBa)
glutamate
Inhibitory, evokes
inhibition postsinaptic
potensial in brain
neuron
Excitatory, evokes
excitation postsinaptic
potensial in brain
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Aspartate
Glycine
Excitatory, evokes
excitation postsinaptic
potensial in brain
Inhibitory, evokes
inhbition postsinaptic
potensial
Mono amines
Dopamine
Histamine
Modulates activity of
adrenergic neuron,
involves in arousal,
motor activity, evokes
EPSPs in brain
Evokes EPSPs in brain
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Norepinephrine (Ne)
Serotonin
( 5-hydroxy-tryptamine )
5-HT
Exitatory and inhibitory,
involved in arousal, motor
activity, visceral function
(heat regulation)
reproduction, acts as
hormone when secretedinto the bloodstream
Involved in sleep, mood,
pain, evokes EPSPs in
brain, apetite
Neuropeptides( neuropeptida )
Somatostatin
Endorphine
Enkephalins
Substance P
Inhibits secretion of growt
hormone
Analgesic properties
Involved in mediating pain
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Contoh, Ach release at sinaptic gap
Sinaptic gap
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Destruksi asetilkolin setelah disekresikan
Lebih kurang 2-3 milidetik setelah asetilkolin disekresikan pada
celah sinap dihancurkan (destruksi) oleh kolinesteraseacetate dan choline
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Zat-zat yang menghambat (inhibition) sekresi neurotransmitter
Nikotinmenempati reseptor Ach pada sel ototefek yang
sama seperti Achlama direuptake untuk dihancurkan oleh
kolinesterasereeksitasikejang (muscle cramp)
D-tubocurarin (curare)suatu senyawa kimia yg terdapat pada
getah tanaman di Amazoninhibisi sekresi Ach ke motor end
plateparalisis pada otot pernapasanmati
Venom (snake)menghambat sekresi Achparalisis otot
pernapasan
Sarin ( gas saraf )menonaktifkan kolinesterase dalam beberapa
mingguspasme pada laryngtercekikmati