ltm 4 asri ginjal.pptx

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     Tatalaksana FarmakologisBPH & OAB

    Asri Salima Ridw14065452

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    OVRA!T"V B#A$$R %OA

    • orang 'ang s()(ntar2

    k( w*+ tidak )isa ta,an

    -i-is %)(s(r

    • $iagnosis m.da,

    • laki2/ dari a.,

    t(r*i.m)a. -(sing  

    OAB

    •   Turunan/ dari(na*in+ soli(n

    •   MA/ antagonis r(s(-tor 3 

    %mikturisi) -ada md(tr.sor

    ).in t,( )ladd(r

    •   Efek  samping/ anti*,olin(rg

    %mulut dan kulit kering karena

     produksi ludah berkurang

    •   Kontraindikasi/ arrowang

    gla.*oma+ .rinar' r(t(ntion+gastro-ar(sis+ gastri* o)str.*

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    B"7 PROSTAT H8PRP#A%BP

    •   Turunan/ P,(no9')(n:amin(+ Pra:osin+ t(ra:osin+ do9a:%)ikin ,i-(rt(nsi+ tams.losin %r(lati aman+ ;000

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    $osis

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    (k Sam-i

    •   Efek  samping/

    • ort,ostati* ,i-ot(nsi %-(n.r.nant(kanan dara, %20 sistol+ 10 diasaat )(rdiri dari -osisi d.d.k ata

    tid.ran• P.sing

    • asal *ong(stion %-(m)(ngakakk-(m).l., dara,  s.m)atan

    • Pal-itasi %,ard )(ats+ ast )(ats+

    irr(g.lar ,(art )(at

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    A7TS FOR B"7 PROSTAH8PRP#AS"A %BPH

     5 - reductase

    inhibitor

    •   Turunan/ =nast(rid( %ti-( 2+

    d.tast(rid( %ti-( 1+ 2

    •   MA/ m(n*(ga, @0? 5

    r(d.*tas( %katalase testosteron  

    dihydrotestosterone (DHT  s,gm(ng,am)at -(rt.m).,an

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     Tipe 1

    di k.lit dan s*al- d(wasa

    %,air ormation

    -rostat( *an*(r %in*r(as(d

    l(>(ls o mRA (9-r(ssion+

    -rot(in+ and .n*tional

    (n:'m(s ,a>( )((n

    d(monstrat(d in -rostat(

    *an*(r

     Tipe  BPH

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     Farmakokinetik /

      Absorpsi/ a)sor)si di .s.s ,al.s+ -(ak tim(/ 12 am+

    )ioa>aila)ilitas ;0?

      Distribusi/ m(n(m).s BBB+ -lasma -rot(in )inding/ @0?

      Metabolime/ Hati ol(, iso(n:im !8P3A4

      Ekskresi/ (s(s %5?+ .rin %3@?

    •   Efek  samping/

    • t(stost(ron )(rk.rang  li)ido )(rk.rang  dis.ngsi s(9.a

    • risiko *a*at )a'i ika Anda m(ng,amili -(r(m-.an saat s(da

    m(nalani -(ngo)atan d(ngan k(d.a o)at ini

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    CS"PD#A

    Al-,a)lo*k(rs+ s(-(rti t(ra:osin m(ringankan g(ala BPH dalam )()(r

    mingg.+ t(ta-i tidak m(ng,(ntikan -ros(s -(m)(saran -rostat6+

    5al-,a r(d.*tas( in,i)itors+ d.tast(rid( ata. =nast(rid( da-at m(ng.

    -(m)(saran -rostat t(ta-i m(m).t.,kan 6 ).lan ata. l()i, .nt.k

    m(n.n.kkan ((k -ada g(ala 6+

    P,os-,odi(st(ras(5 %P$5 in,i)itor+ s(-(rti tadala=l da-at m(m)ant

    m(ng.rangi g(ala BPH a-a)ila m(miliki masala, (r(ksi P$5 in,i)ito

    dik(nal o)at .nt.k (r(ksi 6+

     Eadi+ k(sim-.lann'a adala, a-a)ila s(sorang t(rk(na -(n'akit BPH+ )(

    kom)inasi dari al-,a)lo*k(r d(ngan angka -anang dan 5al-,a r(d.

    in,i)itor kar(na k(d.an a m(m .n ai .n si an )(r)(da dan )(k(r

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    R((r(n1 Fink(l R+ ,al(n C+ Fink(l R+ Pana>(lli T #i--in*ott "ll.strat(d R(>i(ws/ P,arma*olog' 6 t, (d

    P,ilad(l-,ia/ olt(rs Cl.w(rG 2015

    2 Cat:.ng B7 Basi* and !lini*al P,arma*olog' 10t, (d San Fransis*o/ * 7raw HillG 2006

    3 *Anin*, + #.( T Smit, & Tanag,os 7(n(ral Drolog' 1;t, (d !aliornia/ *7raw Hill (di*al

    -2011;

    4 Br.nton #+ #aso E+ (t al 7oodman & 7ilmans T,( P,arma*ologi*al Basis o THRAPDT"!S 11t

    !aliornia/ *7raw HillG 2006 -2102;

    5 S(tia).d' R Anti)ioti*s and Antis(-ti*s or Drinar' Tra*t "n(*tions Eakarta/ $(-art(m(n FarmaFCD" Ik.lia,J Idi)(rikan -ada/ S(lasa+ 16 F()r.ari 2016J

    6 Ro(,r)orn !7 T,( (K(*ts o d.tast(rid(+ tams.losin and *om)ination t,(ra-' on low(r .rinars'm-toms in m(n wit, )(nign -rostati* ,'-(r-lasia and -rostati* (nlarg(m(nt/ 2'(ar r(s.lts

    t,( !om)AT st.d' Eo.rnal o Drolog'+ 1@%2/ 616621 200; %a**(ss(d F() 2 2016 A>aila)l(

    ,tt-/