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SIMPULAN DAN SARAN

SimpulanOptimasi pembuatan nanopartikel ekstrak

temulawak menghasilkan perlakuan terpilih yaitu dengan penambahan TPP 0,5%, dua kaliultrasonikasi selama 60 menit, dan pengeringan semprot. Rendemen yang diperoleh sebanyak 5,47% sedangkan ukuran nanopartikel yang diperoleh dari perlakuan terpilih dengan menggunakan SEM berkisar 470 – 3000 nm. Permukaan nanopartikel ekstrak temulawak lebih halus dan cembung dibandingkan dengan nanokitosan. Hasil ini menunjukkan ekstrak temulawak telah masuk dalam kitosan. Karakterisasi FTIR menunjukkan tidak adanya gugus fungsi kurkumin yang khas pada sampel nanopartikel ekstrak temulawak dengan dua kali ultrasonikasi selama 30 menit dan 60 menit.Akan tetapi, terjadi kenaikan derajat kristalinitas pada sampel nanopartikel kitosan-esktrak temulawak dibandingkan dengan nanopartikel kitosan yang menunjukkan adanya molekul yang mengisi kitosan.

SaranUji in vivo terhadap sampel nanopartikel

ekstrak temulawak diperlukan untuk mengetahui efisiensi dan bioavailabilitas nanopartikel dalam mencapai sistem peredaran darah. Penambahan emulsifier diperlukan untuk mencegah terjadinya penggumpalan pada sampel nanopartikel. Selain itu, pemurnian ekstrak temulawak dan variasi perbandingan ekstrak temulawak dengan kitosan diperlukan untuk mengetahui kadar optimum ekstrak temulawak yang mampu terjerap oleh kitosan.

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