daftar obat generik

1326
Kitab Daftar Nama Obat Generik Faik Fauzi Mulachella by: & Genghis Khun

Upload: meingkar

Post on 27-Apr-2015

1.640 views

Category:

Documents


24 download

TRANSCRIPT

Page 1: Daftar Obat Generik

Kitab Daftar Nama Obat Generik

Faik Fauzi Mulachellaby:

&

Genghis Khun

Page 2: Daftar Obat Generik

DAFTAR NAMA GENERIK OBATKlik Cepat ke: Daftar Isi, Index (Sebaiknya baca Panduan dulu)Saluran CernaKardiovaskulerSaluran NafasNeuromuskulerHormonAntibakteriSaluran KemihMetabolikVitamin & MineralPreparat Mata, Kulit, Telinga, MulutImunologi

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 3: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index“All high-street pharmacists are obliged by law to dispense whatever the doctor has written on the prescription. If your doctor has prescribed a medicine by its brand name, your pharmacist must dispense that brand. However, if a medicine has been prescribed by its generic name, your pharmacist can dispense whatever version of the medicine they have available, because each version will have the same therapeutic effect….…There are a few exceptions to this. There are a handful of medicines that your doctor must prescribe by the brand name. These include:

modified-release theophylline & aminophylline modified-release nifedipine & diltiazem the immunosuppressant ciclosporin lithium, which is a mood stabiliser fentanyl patches carbamazepine, phenytoin and Na valproate

www.netdoctor.co.uk/medicines/brand_generic.htm

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 4: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index

Kitab Daftar Nama Obat Generik Ini Dibuat Untuk Kemaslahatan Orang Banyak.

Semua Boleh Mengcopy dan Menyebarluaskannya. Semoga Bermanfaat. Amin.

by:

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

FB: facebook.com/mulachella

Page 5: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDAFTAR NAMA GENERIK OBATBisa dibuka di semua sistem operasi:Komputer:

- Windows- Linux- Macintosh

HP/ PDA:- Symbian- Windows Mobile

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 6: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSistem PenulisanNama Generik berdasarkan nama internasional I: IndikasiBSO: Bentuk sediaan obat

D: Dosis dan cara pemberian oral *Qd= 1xBid=2xTid=3xHs= sebelum tidurKI: Kontra IndikasiP: PerhatianES: Efek SampingIO: Interaksi ObatPreg: (Tingkat Keamanan untuk Ibu Hamil) A, B, C, D, X*Nama Dagang: Nama ini akan langsung diisi bila distribusi di Indonesia.hanya tersedia 1 (satu) macam nama dagang/ paten tersebutProduk®, Rp. /box, Amp)

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 7: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCara Pemberian Obat OralSimbol:

: Diberikan bersama makanan

: Diberikan bersama atau tanpa makanan

: Diberikan saat perut kosong (1 jam sebelum makan atau 2 jam sesudah makan)

Tingkat Keamanan untuk Ibu HamilA: Aman pada janin manusiaB: Aman pada janin binatang percobaan.C: Efek samping pada janin binatang percobaan, pada manusia belum diketahui. D: Efek samping pada janin manusia, tetapi manfaat obat mungkin lebih besar daripada resikonya.X: Abnormalitas pada janin manusia. Resiko melebihi manfaat yang diperoleh.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 8: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCara Pencarian Data1. Panduan Daftar Isi, atau 2. Mengaktifkan Bookmark disamping halaman PDF

viewer atau 3. Melihat Index (Berdasarkan urutan abjad).4. Fasilitas Search.. (Tekan Ctrl+F) : Tulislah dengan

nama generik internasional, misalnya “hydroxide”, jangan ditulis “hidroksida”

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 9: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexI. SALURAN PENCERNAANA. ANTASIDA & ANTI ULCERASIB. REGULATOR GIT, ANTI FLATULEN & ANTI INFLAMASIC. ANTI SPASMODIKD. ANTI DIAREE. LAKSATIF & PENCAHARF. DIGESTANG. KOLAGOGUM, KOLELITOLITIK & HEPATIK PROTEKTORH. PREPARAT ANOREKTAL

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 10: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexA. Antasida & anti ulcerasiAluminium hydroxide/ AntacidMagnesium hydroxideMagnesium trisilicate Cimetidine Ranitidine HClFamotidineNizatidineOmeprazoleLansoprazoleRabeprazolePantoprazoleEsomeprazoleClebropride MalateMisoprostolSulpirideSucralfateTeprenoneRebamipidePolymigel

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 11: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAluminium hydroxide/ AntacidI: Hiperasiditas lambung, pengikat fosfat pada kasus hiperfosfatemia pada gagal ginjal.BSO: Tablet Kunyah 300mg

D: 1-2 tab/ hr, 1 jam stlh makan & sebelum tidur .KI: Payah ginjalP: Insuffisiensi GinjalES: Jarang, konstipasi, diare. Hipofosfatemia (jangka lama, dosis tinggi)IO: Perubahan absorbsi terutama tetrasiklin dan garam FePreg:: C

Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 12: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMagnesium hydroxideI: Konstipasi & defekasi tdk teratur yg disertai ggn pencernaan.BSO: Syr 400mg/5cc D: Dws 2,4g – 4,8 g sblm tidur/ ssdh bangun tidur. Anak 1,2g-

2,4 g. KI: P: Kerusakan ginjalES: Mual muntah, nyeri perutIO: Mengganggu absorpsi Cimetidin/ TetrasiklinPreg:: B

Nama Dagang:Laxasium

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 13: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMagnesium trisilicateI: Hiperasiditas GIBSO: Tab, Syrup

D: Perut Kosong/ menjelang tidur/ timbul gejala. Tdk >7 hrKI: Anak <10th, ggl ginjal, hypophosphataemiaP: Insufisiensi ginjal, hypermagnesaemia, nefrolitiasis, ES: Diare, mual, muntah, depresi SSP, osteomalasia pada defisiensi fosfor, osteomalasia, batu ginjal.IO: Mengganggu absorbsi TetrasiklinPreg::

Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 14: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCimetidineI: Ulkus duodenum & gaster jinak, ulkus sal GI bag atas,ulkus stoma, ulkus stress, sindroma Zollinger-Ellison, mastositosis sistemik, adenoma endokrin multipel. BSO: Kaplet 200 mg, injeksi 200 mg

D: Dws 400 mg pagi & malam, atau 200 mg 3x/hr waktu makan dan 400 mg menjelang tidur. Lama terapi 4 mgg. Anak 20-40 mg/kgBB/hr dlm dosis terbagi.KI: Hipersensitif thd CimetidineP: Ggn ginjal, hamil, laktasi, keganasan lambung.ES: Diare, pusing, ruam kulit. Ginekomastia, impotensi (pria). Kebingungan reversible. alergi, artralgia, myalgia, kelainan darah, nefritis interstisialis, sakit kepala, hepatotoksik, pankreatitis.IO: Meningkatkan efek Lidocaine, Phenytoin, Theophylline, Warfarin, bbrp antiaritmia, Benzodiazepine, vasodilatorPreg:: BNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 15: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexRanitidine HClI: Ulkus duodenum, ulkus gaster jinak,refluks esofagitisBSO: Tab 150 mg. Amp 50 mg/ 2cc D: Ulkus duodenum Dws 150mg 2x/hr selama 4-8mgg.Sindrom Zollinger Ellison 150mg 2x/hr dpt ditingkatkan s/d 6 g/hr. Ulkus Gaster 150 mg 2x/hr selama 2 mgg. Pemeliharaan: 150 mg sblm tidur.

Refluks Esofagitis 150mg 2x/hr. KI: HipersensitifP: Riw. Porfiria akut. Bumil & laktasi. Ggn fungsi hati & ginjal. Lanjut usiaES: Sakit kepala, malaise, insomnia, vertigoIO: Dg Warfarin meningkatkan/menurunkan waktu ProtrombinPreg:: BNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 16: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFamotidineI: Ulkus duodenum, ulkus gaster jinak, sindroma Zollinger Ellison, refluks esofagitisBSO: Tab 20 mg

D: 40 mg 1x/hr atau 20 mg 2x/hr KI: P: Ggn ginjal beratES: TrombositopeniaIO: Preg:: B

Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 17: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNizatidineI: Tukak duodenal, refluks esofagitisBSO: Kapl 150 mg, Amp 25 mg/cc D: Tab 150-300 mg 2x/hr selama 8-12 mgg. Infus IV kontinu: 150-300 mg dalam 150cc larutan. Rata-rata 10 mg/ jam. Maks:

480 mg/hr. KI: HipersensitifP: Insufisiensi ginjal, bumil & laktasiES: IO: Preg:: BNama Dagang:Axid

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 18: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexOmeprazoleproton pump inhibitorI: HiperasiditasBSO: Kaps 20 mg

D: 1x/hr ditelan utuh. Terapi tdk > dr 4 mggKI: Bumil & Laktasi.P: Umur dibwh 18 th. Gangguan LiverES: Flatulen, VertigoIO: Mengurangi efektifitas obat anti HIV & anti fungi. Peningkatan kadar dlm darah: warfarin, phenytoin, benzodiazepines (such as diazepam, triazolam, lorazepam or flurazepam), digoxin, cilostazol, tacrolimus.

Preg:: A, B, C, D, X

Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 19: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLansoprazoleProton pump inhibitor I: Ulkus gaster & duoenumBSO: Kaps 30 mgD: Dws 30mg 1x/hr KI: Ggn hati beratP: AnakES: IO: Preg:: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 20: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexRabeprazoleBSO: Tablet 10 mg, 20 mg D: Dws 1x 20 mg/hr. Tukak Duodenum aktif 1x 10 mg/hr. sembuh dlm 2-4 mgg. Pasien Tukak lambung sembuh dalam 4-6 mgg. Refluks esofagitis 1x 20 mg/hr selama 4-8 mgg. Pagi

I: Tukak Duodenum, Tukak lambung, Refluks esofagitisP: Ggn fungsi ginjal, hipersensitif. Usia lanjut. Bumil & Laktasi. Anak.ES: Konstipasi, eksema, sakit kepala, peningkatan GPT, lekosit eosinofilik & GOTIO: Menurunkan kadar Ketokonazole, meningkatkan konsentrasi digoxin dlm darah. Tdk berinteraksi dg obat yg dimetabolisme scr oksidatif: Teofilin, Fenitoin, Warfarin & Diazepam.Preg:: B Nama Dagang:Pariet

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 21: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPantoprazoleI: Terapi jangka pendek ggn gaster & intestinal yg memerlukan pengurangan sekresi as lambung; ulkus duodenum, ulkus gaster; refluks esofagitis.BSO: Tab 20 mg, 40 mg. Vial 40 mg

D: Tab 40 mg/hr slm 2-8 mgg. IV 40 mg/hr slm < 8 mgg. KI: Kerusakan hati. Hamil.P: IV digunakan bila IO tidak memungkinkan.ES: sakit kepala, diare, ruam kulit, pruritus.IO: Mempengaruhi penyerapan KetokonazolePreg:: B

Nama Dagang:Pantozol

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FB: facebook.com/mulachella

Page 22: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexEsomeprazoleI: Refluks Gastroesofageal, Kombinasi antibakteri utk eradikasi H. pyloriBSO: Tab 20 mg, 40 mg. Vial 40 mg/cc D: Tab Refluks Esofagitis Erosif 1x 40 mg/hr slm 4 mgg. Relaps esofagitis & pemeliharaan 1x 20 mg/hr. Vial Dws 40 mg iv

pelan/ infus slm 10-30mnt.KI: P: Bumil Laktasi. Intoleransi fruktosa herediter. Malabsorbsi Glukosa Galaktosa. Insufisiensi sukrase isomaltase.ES: Diare, Kembung. Mual, konstipasi, dermatitis, pruritus, mulut kering.IO: Diazepam, Sitalopram, Imipramin, Klomipramin, FenitoinPreg:: B Nama Dagang:Nexium

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 23: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexClebropride MalateI: Ulkus peptikum, GastroduodenitisBSO: Tab 0,5 mg

D: Dws 3x/hr KI: Bila stimulasi lambung membahayakan (perdarahan, obstruksi, perforasi). Pasien diskinesia tardiv thd neuroleptik.P: anak, bumil trim 1, laktasi.ES: Mengantuk, pusing.IO: mempotensiasi sfek SSP Fenotiazin & antidopaminergik lain.Preg::

Nama Dagang:Clast

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 24: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMisoprostolI: Mencegah ulkus krn induksi AINSBSO: Tab 200 mcg

D: 4x 200 mcg/hr. KI: Bumil, LaktasiP: ES: Ggn GI: diare, nyeri perut, ggn ginekologi (kram, bercak, menoragi, dismenorre)IO: Preg:: X

Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 25: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSulpirideI: Psikosomatik, ulkus peptikum, colitis ulseratif, peny Crohn, Ggn kolik fungsional, migren abdominal.BSO: Kaps 50 mg, Tab forte 200 mg. Amp 100 mg/ 2cc D: Ggn psikofungsional 2-4 kaps/ hr. Anak 5-10 mg/kgBB/hr dibagi bbrp dosis. Psikiatri pengobatan wkt serangan 3-6 amp/hr (IM).

Pemeliharaan 2-4 tab/hr dibagi bbrp dosis. KI: FeokromositomaP: Insufisiensi Ginjal, epilepsy. Bumil & Laktasi. Manula: Parkinson. ES: Galaktore, ginekomastia, impotensi/ frigid, amenore, reaksi extra pyramidal, hipotensi ortostatik, diskinesia tardiv, sedasi & somnolen.IO: Obat Depresan, SSP, alcohol, Levodopa.Preg:: Nama Dagang: Dogmatil

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 26: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSucralfateI: Terapi jangka pendek (8 mgg) ulkus duodenumBSO: Tab 500 mg, Susp 500 mg/ 5cc

D: 4x 1 g KI: P: GGK, dialysis, Bumil, laktasi, Anak.ES: Konstipasi, mulut kering, ggn GI, ruam kulit, gatal, ggn tidur, nyeri punggung.IO: Menurunkan absorbsi Cimetidine, Fluoroquinolon (Ciprofloxacin, Norfloxacin), Digoxin, Ketokonazol, Fenitoin, Ranitidine, Tetrasiklin, Quinidin, L-tiroksin, Teophylline. Preg:: B

Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 27: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTeprenoneI: Tukak peptikBSO: Kaps 50 mg

D: 3x 50 mg/hrKI: P: Bumil & anakES: Jarang: konstipasi,rasa penuh pd perut, diare, haus, mual, muntah, ruam kulit, gatal.IO: Preg::

Nama Dagang:Purubex

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 28: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexRebamipideI: Ulkus gaster, antagonis H2 BSO: Tab 100 mg D: 3x 100 mg/hrKI: P: Hamil,laktasi, lansiaES: abdomen terasa membesar, konstipasiIO: Preg::

Nama Dagang:Mucosta

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 29: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPolymigelI: Mual, hiperasiditas, nyeri abdomen, kembungBSO: Tab 400 mg D: 1-2 tab 3-4x/hrDosis KI: Hipo/hipertiroidisme,dialisisP: Hiperkalsemia, diet rendah fosfat, disfungsi ginjal pd penggunaan lama ES: Konstipasi, diare, mual, muntahIO: Mengurangi absorbsi bila kombinasi dg Cimetidine, TetrasiklinPreg::

Nama Dagang: Strocain P

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 30: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexB. Regulator GIT, Anti Flatulen & Anti InflamasiMetoclopramide HClDomperidoneCisaprideDimeticoneSimeticoneSulfasalazineMesalazineRamosetronOtilonium bromideLactobacillusTegaserod

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 31: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMetoclopramide HClI: GGn GI, mual/ muntah krn obat, kembung, ulkus peptikum, stenosis pylorus (ringan), dyspepsia, epigastralgia. BSO: Tab 5 mg, 10 mg, amp 10 mg/2cc, syrup 5 mg/5cc.Supp 10 mg, 20 mg. Tetes paed. 1 mg/ 10 tts.

D: Tab, Amp,Supp: Dws 3x 10 mg/ hr Anak 0,5 mg/kg/hr.KI: Jika stimulasi motilitas GI dpt membahayakan. Ex. Obstruksi intestinal, epilepsy, feokromositoma.P: Anak & remaja, kehamilan, menyusui, DM, depresi, penggunaan obat lain yg menyebabkan reaksi extrapiramidal.ES: Dosis tinggi: pusing, gelisah, lesu, gejala extrapiramidal, sakit kepala, mengantuk, ggn GI, hipertensi.IO: Efek diantagonis oleh antikolinergik & analgesic. Depresan SSP meningkatkan efek sedasi. Absorbsi digoxin & simetidin terganggu. Absorbsi parasetamol, tetrasiklin, levodopa di usus halus akan meningkat. Perubahan kebutuhan insulin.Preg:: B Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 32: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDomperidoneI: Dispepsia disertai masa pengosongan lambung yg lambat atau refluks esophagus. Mual & muntah krn: intoleransi sal cerna akibat kemoterapi antikanker, digitalis, levodopa, radioterapi, patologi organ abdomen, GI, hepatobilier, peritoneal, ginjal.BSO: Tab 10 mg, Sirup 5mg/5cD: Dws 10-20 mg 3x/hr perut kosong (bila perlu tambah sblm

tidur) , anak 0.25-0.5 mg/kgBB 3x/hr.KI: Pasien dg serangan motilitas lambung dpt membahayakan, missal perdarahan, obstruksi mekanik, perforasi GI. Prolaktinoma tumor hipofise yg mengeluarkan prolaktin. P: Tidak utk mual/ muntah kronik. Bumil laktasi, bayi < 1th. ES: Galaktorea, ginekomastia, kejang usus sementaraIO: Antasida, obat anti sekresi.Preg:: Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 33: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCisaprideI: Ggn motilitas GI spt gastroparesis & Refluks esofagitis.BSO: Tab 5 mg D: Dws 5 mg 3-4x/hr, max 40 mg/hr. Anak 0.2-0.8 mg/kgBB

3-4x/hr,max 40 mg/hr.KI: Stimulasi GI berbahaya, perdarahan GI, obstruksi mekanik/ perforasi.P: Insufisiensi hati/ ginjal. Bumil & laktasi. Prematur dg kehamilan < 34mggES: Kram abdomen sementara, borborigmis & diare. IO: Peningkatan absorbsi depresan SSP & alcohol. Efek motilitas GI diturunkan oleh antikolinergik.Preg:: C

Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 34: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDimeticoneI: Flatulen & meteorismus. Mengurangi gas sal cerna sblm radiografi. Meringankan distensi abdomen. Dispepsia.BSO: Tab 40 mg D: 40 mg 3x/hr & sblm tidur. 4x/hr sblm pemeriksaan radiografi.

KI: P: ES: IO: Preg::

Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 35: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSimeticoneI: Kembung & Rasa tidak enak pada perut. Distensi abdomen & dyspepsia. Sbg defoaming agent pd radiografi & endoskopi sal cernaBSO: Tab 125 mg

D: 125 mg 3x/hr KI: Neonatus & prematurP: ES: IO: Preg:: C

Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 36: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSulfasalazineI: Kolitis ulseratif, RA, spondilitis ankylosing, spondyloartritis seronegatif.BSO: Kaplet 500 mg D: Kolitis ulseratif: Dws 3-4 g, Anak 40-60mg/kgBB/hr dlm dosis terbagi.AR, spondilitis ankilosa: 500 mg malam hari selama 1 mggu, dilanjutkan 500 mg 2x/hr mggu selanjutnya.KI: Porfiria intermiten akut. Anak < 2th. Obstruksi GIT & UTI.P: Ggn hati/ ginjal, diskrasia darah, defisiensi G6PD. ES: Mual, anoreksia, kenaikan suhu, eritema & pruritus, sakit kepala. IO: Mengurangi absorbsi Folat & Digoxin.Preg:: B, D bila mendekati partus Nama Dagang: Sulcolon

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 37: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMesalazineI: Radang usus, Colitis ulseratif, pnykt Crohn, Enema. BSO: Tab 250 mg, Enema 4g, Supp 500mg D: Dws: akut 1.5- 3g 3x/hr. Maintenance 500mg 3x/hrDosis.

Enema 1x/hr. Supp 2x/hr. KI: Kelainan hati & ginjal berat. Ulkus peptic aktif. Pembekuan darah abnormal.Bayi & Infant. P: manula, bumil & laktasiES: Eksantema alergi, demam, bronkospasme.IO: Meningkatnya efek hipoglikemik Sulfonilurea. Kumarin, MTX, Probenesid, Sulfinpirazon, Furosemid & Rifampisin.Preg:: BNama Dagang:Salofalk

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 38: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexRamosetronI: Mual & muntah karena obat karsinostatik (misal Cisplatin)BSO: Tab 0.1 mg, Amp 0.3 mg/2cc

D: Dws Tab 0.1 mg 1x/hr. Amp 0.3 mg 1x/hr. Max 0.6 mg/hr.KI: P: Sebaiknya diberikan 1 jam sebelum obat karsinostatik. Manula, Bumil & laktasi.ES: syok & reaksi anafilaktik, serangan yg menyerupai epilepsy, ggn tidur, konstipasi, diare, peningkatan BUN, ggn fungsi ginjal, peningkatan SGPT/SGOT/LDHIO: Preg::

Nama Dagang:Nasea

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 39: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexOtilonium bromideI: Irritable Bowel syndrome & pengobatan simtomatis utk nyeri & ggn GI yg berhubungan dg spasme otot polos.BSO: Tab 40 mg

D: 40 mg 2-3x/hr. KI: P: Glaukoma, hyperplasia prostate jinak, stenosis pilorik. Hamil & Laktasi.ES: Mual, lelah, nyeri epigastrium, vertigo.IO: Preg::

Nama Dagang:Spasmomen

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 40: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLactobacillusI: Pemeliharaan kesehatan fungsi GIT BSO: Tab, Kapsul D: 3x/hr.KI: P: Bumil & LaktasiES: IO: Preg::

Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 41: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTegaserodI: ‘Irritable bowel syndrome’, predominan konstipasi, khususnya wanita. Rasa tidak enakpada perut.BSO: Tab 6 mg

D: 6mg 2x/hr selama maks 12 mingguKI: LaktasiP: Kerusakan hati berat,hamil.ES: Nyeri abdomen, diare,mual, flatulensi, sakit kepala, pusing, nyeri punggung & sindr seperti flu.IO: Preg:: B

Nama Dagang:Zelmac

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 42: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexC. Anti SpasmodikPapaverine HClPramiverineMebeverineHyoscine butylbromideButropium BromidePropantheline bromideValethamate bromideTimepidium bromideChlordiazepoxideTiemonium methylsulphate

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FB: facebook.com/mulachella

Page 43: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPapaverine HClI: Kolik sal empedu, ginjal & otot polos lainnya, emboli perifer & mesenteric.BSO: Tab 40 mg, amp 40 mg/cc D: Tab, SC, IM, IV 40-80 mg 3x/hr. KI: P: Pemberian IV, GlaukomaES: IO: Preg:: A, B, C, D, X

Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 44: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPramiverineI: Kolik & Kejang otot polos: sal cerna, empedu & sal kemihBSO: Tab 2 mg

D: 2 mg 3x/hr . Akut 4 mg 2x/hr selama 2 hr.KI: Glaukoma sudut sempit, adenoma prostate dg tendensi terbentuknya sisa urine, takiaritmia, stenosis mekanik sl GIT, megakolon, paska bedah abdomen.P: Hipotensi, bayi, bumil.ES: Rasa kering mulut& kulit, ruam kulit, pandangan kabur, glaucoma, takikardia, ggn kencing.IO: Peningkatan efek antikholinergik dg amantadin atau antidepresan trisiklik.Preg::

Nama Dagang:Systabon Plain

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 45: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMebeverineI: Ggn spasme kolon. Sindr ‘Irritable colon’ stadium awal & yg disertai luka pada GIT (divertikulosis & divertikulitis pd kolon, enteritis regional, pnykit kandung empedu, tukak lambung & usus 12 jari, disentri, inflamasi spesifik & non spesifik GIT). BSO: Tab salut gula 135 mg

D: 135 mg 3x/hr, 20 menit a.c KI: P: ES: IO: Preg:: BSO: Nama Dagang:Duspatalin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 46: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexHyoscine butylbromideI: Spasme GIT & Sal kemih. Pencegahan & terapi dismenore.BSO: Tab 10 mg, ampul 20 mg/cc

D: Dws 10-20 mg 4x/hr, anak 10 mg 3x/hr. KI: Hipersensitif, porfiria, glaucoma, hipertrofi prostate dg kecenderungan retensi urine, stenosis mekanis GIT, takikardia, megakolon.P: Bumil, laktasi, lansia, ggn jantung, colitis ulseratif, ileus paralitik, stenosis pilorik. Hindari minuman alcohol.ES: Kering mulut & kulit, konstipasi, palpitasi, aritmia jantung, bradikardi, takikardia, reaksi paradoksikal, ggn penglihatan.IO: Antihistamin, antidepresan, kuinidin, disopiramid, alcohol, antidepresan, analgesic narkotik, sedative/ hipnotik, kalium klorida.Preg:: C Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 47: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexButropium BromideI: Nyeri, kejang yg berhubungan dengan gastritis, enteritis, tukak peptic, kolesistitis, diskinesia bilier.BSO: Tab 5 mg.D: 10 mg 3x/hr.KI: Glaukoma, Ggn sal kemih krn hipertrofi prostate, ggn jantung berat, ileus paralitik, stenosis pylorus, hipersensitif.P: Hipertrofi prostate, gagal jantung kongestif, aritmia, colitis ulseratif, hipertiroidisme. Bumil.ES: Ggn daya akomodasi mata. Mulut kering. Mual,muntah, konstipasi, ggn miksi, sakit kepala, mengantuk, pusing, takikardia, hipotensi, muka merah, lesu, reaksi hipersensitif.IO: Antidepresan trisiklik, Fenotiazin, MAOIPreg:: C

Nama Dagang: Coliopan

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 48: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPropantheline bromideI: Terapi tambahan ulkus peptic & colitis ulseratif, divertikulitis, divertikulitis, kolesistitis, pankreatitis & prosedur diagnostic GI. Utk pengobatan sindr usus iritabel, kolik ginjal & hiperhidrosis.BSO: Tab 15 mg

D: Ulkus peptic 15 mg a.c & 30 mg sblm tidur. Kontras: 30 mg, 45 menit sblm foto. Indikasi lain 15-30 mg 4x/hr. KI: Penyakit obstruktif GI/ Sal kemih. Atoni usus. Colitis ulseratif berat atau toksikmegakolon, hiatal hernia sehubungan dg refluks esofagitis, perdarahan akut, miastenia gravis, glaucoma.P: Panyakit KV berat, lansia, neuropati otonomik, colitis ulseratif, peny hati/ ginjal, hipertiroid, peny jantung kongestif, PJK, hipotensi.ES: Mulut kering, pandangan kabur, midriasi, efek SSP, takikardia, retensi urine, ‘heat stroke’, ggn GI, dermatitis alergi, impotensi, anafilaksis, konstipasi.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 49: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIO: Meningkatkan kadar digoksin serum, potensiasi efek kolinergik dari antihistamin, antidepresan, antipsikotik, obat anti Parkinson.Preg:: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 50: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexValethamate bromideI: GI spasm (cardiospasm, spastic constipation, ulcerative complaints), spasm of biliary & urinary tract, spasmodic dismenore, delayed dilatation of cervix in parturition. Child: Pylorospsm, spastic bronkhitisBSO: Tab 10 mg, Amp 8 mg/cc.D: Tab 10-20 mg 3x/hr. Amp 8-16 mg IV/ IM/ SCKI: Glaukoma sdt tertutup, obstruksi GIT/ UT, hipertrofi prostate, megakolon, stenosis pylorus.P: ES: Sikloplegia, mydriasis, mulut kering, flushing, takikardi, palpitasi, konstipasi, rash, muntah, fotofobia.IO: Efek antikholinergik bias ditingkatkan oleh parasimpatolitik lain. Preg:: A, B, C, D, X Nama Dagang: Epidosin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 51: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTimepidium bromideI: Spasme otot polos.BSO: Kaps 30 mg, Amp 7.5 mg/cc D: Kaps 30 mg 3x/hr Amp 7.5mg SC/IM/IV.KI: Glaukoma, disuria, gagal jantung, ileus paralitikP: hipertrofi prostate, hipertiroidisme, CHF, aritmia, colitis ulseratif idiopatik.ES: Fotofobia, mulut kering, vertigo, palpitasi, konstipasi, disuria.IO: Efek ditingkatkan oleh Trisiklik antidepresan, Phenothiazine, MAOIsPreg::

Nama Dagang: Sesden

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 52: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexChlordiazepoxideI: Nyeri spastic, dismenore, tukak peptik.BSO: Tab 5 mg

D: 1-2 drag 3x/hrKI: Glaukoma sudut sempit akut, miastenia gravis, syok, psikosis berat.P: Ketergantungan, amnesia & serangan grandmal, penyakit otak organic, insufisiensi kardiorespiratoris, penurunan fungsi hati/ ginjal. Gagal nafas/ PPOK. Bumil/ laktasi. Lansia. ES: Lesu, ngantuk, lemah otot.IO: Meningkatkan efek Depresan SSP pada alcohol, barbiturate, antihistamin, fenotiazin, opiate, Fenitoin (potensiasi), meningkatkan efek relaksasi otot dg benzodiazepine & relaksasi otot lainnya. Antasida mengganggu absorbsi di GI Preg:: D Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 53: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTiemonium methylsulphateI: Spasme sal cerna, sal nafas, sal kemih.BSO: Sir 10 mg/5cc D: Dws 5-15cc 3x/hr Anak 15cc/5cc/kgBB/hrKI: Glaukoma, hyperplasia/ adenoma prostate.P: Bumiltrim 1 ES: IO: Preg::

Nama Dagang:Visceralgine

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 54: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexD. Anti DiareLoperamide HClDioctahedral smectiteKaolin, PectinAttapulgitRacecadotrilFurazolidoneCharcoalBismuth salicylateParomomycin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 55: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLoperamide HClI: Diare akut non spesifik & diare kronisBSO: Tab, Kaps 2 mg D: Awal 4 mg diikuti 2 mg tiap selesai BAB, maks 16 mg/hr. Tidaklebih dari 2 hari.KI: Anak <12 th, colitis akut yg dpt menyebabkan megakolon toksik, kondisi dimana konstipasi hrs dihindari.P: Insufisiensi hati & ginjal. Tidak untuk diare akut krn einfeksi E coli, Salmonella & shigella sp. Tidak untuk diare berdarah & demam tinggi. Bumil laktasiES: Kembung, konstipasi, mual, muntah, nyeri abdomen, lelah, ngantuk, pusing, megakolon toksik.IO: Tranquilizer, alcohol, penghambat MAO. Preg:: B

Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 56: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDioctahedral smectiteI: Diare non spesifikBSO: Sachet 3 g D: Dws & anak >12 thn 3 sachet/hr, 6-12 thn 1-2 sachet/hr. < 6 th sesuai petunjuk dokter.KI: P: DehidrasiES: KonstipasiIO: Mengganggu absorbsiPreg::

Nama Dagang:Smecta

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 57: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexKaolin, PectinI: Diare non spesifikBSO: Tab (K 550 mg+P 20mg),Susp (K 5.832 g+ P 130 mg) per fl oz, atau (K 700 mg+ P 50 mg)D: Dws & anak >12 thn 2.5 tab/diare maks 15 tab/hr, 6-12 thn 1.5 tab/diare maks 7.5 tab/hr.KI: Obstruksi intestinal, hipersensitifitas P: Anak< 6 th. Jangan digunakan >2 hr & demam.ES: IO: Preg::

Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 58: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAttapulgitI: Diare non spesifikBSO:Tab (600mg), (A 600mg/ 700mg/ 750mg+Pectin 50mg)

D: Dws 2 tab/diare maks 12 tab/hr. Anak ½ dosis dws. KI: Obstruksi usus. Anak <6thn.P: Tdk utk diare dg demam tinggi.ES: KonstipasiIO: DigoksinPreg:: Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 59: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexRacecadotrilI: Bila rehidrasi oral tidak membantuBSO: Kaps 100 mg D: Dws & Anak >15thn 100mg Dosis Tunggal. Terapi selanjutnya 8jam kemudian sampai diare berhenti, maks 400mg/hr. KI: Bumil laktasi.P: Anak <15 thn tidak dianjurkanES: Ngantuk, mual, muntah, konstipasi, pusing, sakit kepala, ruam kulit.IO: Preg::

Nama Dagang:Hidrasec

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 60: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFurazolidoneNitrofuran with antiprotozoal activity. I: Diare spesifik & Enteritis krn Salmonella, shigella, Staph aureus, Streptococcus faecalis, E coli, Entamoeba histolitika, Giardia intestinalis. BSO: Sir 50mg/5cc D: Dws & Anak >12th 50-100mg, 5-12th 25-50mg, 3bln-1th 12.5mg. 4x/hr selama maks 7hr.KI: Bayi <3 blnP: Bumil laktasi.ES: Pusing, mual, muntah, bintik merah kulit, hipotensi, demam, artralgia, hemolisis akut pd G6PD.IO: alcohol, Antidepresan guanetidin, metildopa, reserpin, efedrin, amfetamin,fenilefrin, tiramin.Preg:: C

Nama Dagang:Neo Prodiar

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 61: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCharcoalFor maximum effect, administer within 30 min after ingesting toxic agents.I: Diare, kembungBSO: Tab 250 mg.D: Dws 750mg-1g 3x/hr. Anak 250-500mg.KI: P: ES: Muntah, konstipasi, feses hitam.IO: antidotum oral spesifik. Menurunkan kerja Ipecacuanha & emetic lain. Dg bbrp obat oral: menimbulkan efek simultan. Preg:: CNama Dagang:Bekarbon

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 62: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexBismuth salicylateI: Diare Non spesifikBSO: Tab 375mg D: Dws 375mg tiap 30mnt-1jam maks 8 dosis/hr.KI: Baru sembuh dari Influenza. Alergi thd Acetosal. Bayi, anak <12 thn. Manula.P: Bumil laktasi. Dianjurkan banyak minum. Pasien DM/ Gout/ yg mendapat terapi antikoagulanES: Lidah & Tinja hitam.IO: Dapat menurunkan kadar Doksisiklin dlm tubuh.Preg:: C

Nama Dagang: Scantoma

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 63: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexParomomycin sulfateAmebicide I: Acute and chronic intestinal amebiasis; preoperatively to suppress intestinal flora; tapeworm infestations; treatment of Cryptosporidium BSO: Capsule: 250 mgD: Oral: Dientamoeba fragilis: 25-30 mg/kg/hr. dlm 3 dosis slm 7 hari. Cryptosporidium: Adults with AIDS: 1.5-2.25 g/hr. Dlm 3-6 dosis for 10-14 days (up to 4-8 weeks may be needed) Tapeworm (fish, dog, bovine, porcine): Children: 11 mg/kg every 15 minutes for 4 doses Adults: 1 g every 15 minutes for 4 doses Hepatic coma: Adults: 4 g/day in 2-4 divided doses for 5-6 days Dwarf tapeworm: Children and Adults: 45 mg/kg/dose every day for 5-7 days KI: Intestinal obstruction, renal failure, hypersensitivityP: Use with caution in patients with impaired renal function or possible or proven ulcerative bowel lesions

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 64: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexES: 1% to 10%: Gastrointestinal: Diarrhea, abdominal cramps, nausea, vomiting, heartburn <1%: Headache, vertigo, exanthema, rash, pruritus, steatorrhea, secondary enterocolitis, eosinophilia, ototoxicity IO: Decreased effect of digoxin, vitamin A, and methotrexate Increased effect of oral anticoagulants, neuromuscular blockers, and polypeptide antibiotics

Preg: CBSO: Nama Dagang:Gabbryl

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 65: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexE. Laksatif & PencaharBisacodylLactuloseSodium PicosulfateIsphagulaDocusate sodiumNifuroxazide

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 66: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexBisacodylI: Kontipasi. Nyeri saat BAB pd hemoroid. Pre& post operasi. Persiapan Barium Enema. Persiapan Us besar utk Proktosigmoidoskopi.BSO:Tab 5mgSupp 5mg, 10mg D: Dws 10-20mg bedtime. Anak 5-10mg. KI: Obstruksi usus kecil, keadaan yg memerlukan pembedahan abdomen segera, dehidrasi berat.P: Anak, bumil.ES: Rasa tidak enak pada perut, diare.IO: Antasida, susu, obat lain yg , meningkatkan pH lambung.Preg:: BNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 67: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSorbitolI: Konstipasi, rectal & sigmoid, kehamilan, fekaloma & skibala. Persiapan pra-op (partus, ginekologi, pembedahan anus)BSO :Sacchet 5gEnema 5cc

D: Dws 5 g 3x/hr KI: P: ES: IO: Preg::

Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 68: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLactuloseI: Konstipasi kronikBSO: Sirup 66,7%/5cc, 10g/15cc, 3.335g/5cc.D: 10g/hr maks 40g/hr. KI: Pasien galaktosemia yg membutuhkan diet rendah galaktosa.P: DM. Bumil laktasi, manula, anak.ES: Kembung, diare, kram lambung, hipokalemia, hipernatremia, mual, muntah.IO: Neomisin & antibiotic lain.Preg:: BNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)FB: facebook.com/mulachella

Page 69: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSodium PicosulfateI: SembelitBSO: Tetes 7.5 mg/cc D: Dws 8-12tts malam hari.KI: Operasi abdomen akutP: Jangka lama/ dosis tinggi.ES: Hipokalemia IO: Absorbsi diganggu oleh antibiotic spectrum luas Preg::

Nama Dagang:Laxoberon

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 70: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIsphagulaI: Melancarkan regulasi feses pada konstipasi, hemorrhoid, fissure ani,op abdomen/ anus.BSO: Sachet 5 gD: Dws & anak >12th 1 sachet 2-6x/hrKI: IDDM tak terkontrolP: Turunkan dosis insulin pada IDDMES: kembungIO: AntidiarePreg:: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 71: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDocusate sodiumI: KonstipasiBSO: Tab/ Kaps 100 mg, 250 mg, 50 mg Syr mg/15 mlD: single Dose KI: P: ES: stomach ache, cramping or irritated throat (liquid forms). If these effects continue or become bothersome, inform your doctor. Dehydration and loss of essential nutrients. Symptoms include muscle cramps, muscle weakness or dizziness. IO: Preg:: A, B, C, D, X Nama Dagang: Waxsol

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 72: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNifuroxazideI: Diare krn E. Coli, kolopati spesifik & non spesifikBSO: Syr 250 mg/ 5cc D: Dws 1-2 sdt 3x/hr, Anak & Bayi>6 bln 1 sdt 3x/hr. < 6 bln 1 sdt 3x/hrKI: kerusakan fungsi ginjal dan hati. Hipertiroid. Intoleransi Yodium.P: kelainan neurologiES: Neurotoksisitas berat. Nyeri abdomen, diare, pigmentasi warna hijau pd lidah, urine & feses. Kerusakan serebralIO: Preg:: A, B, C, D, X

Nama Dagang:NifudiarNifural

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 73: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexF. DigestanPancreatin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 74: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPancreatinI: Gangguan pencernaanBSO: Tab 150mg, 300mg, 400 mg

D: 1x/hrKI: P: Preg:: A, B, C, D, X ES: Diarrhea, constipation, stomach ache, nausea, bloating, gas, loss of appetite, headache, fatigue or dizziness the first few days as your body adjusts to it. Dizziness or drowsiness. IO: Antasid Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 75: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexG. Kolagogum, Kolelitolitik & Hepatik ProtektorOrnithinChenodeoxycholic acidUrsodeoxycholic acidAmino acids

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 76: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexOrnithinIndikasi: Ggn fungsi hati, Hiperammonia karena pnykt hepar, sirosis hepatis, ensefalopati

Kemasan DosisAmpul 0,5 mg/cc 4-8 Ampul/ hr, max infus 5g/hrKaps 250 mg 1-3x/hr ssdh makan

Kontra Indikasi: Skizofrenia, insomnia, anakEfek Samping: Mual, muntah Preg:: Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 77: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexChenodeoxycholic acidIndikasi: Batu empedu radiolusenBSO: kaps lunak 250mgD: 15 mg/kg/hrKontra Indikasi: Pnykit hati kronik, Gagal Ginjal, ulkus peptikum, radang usus halus, hamil, laktasi, puasaP: Monitor fungsi hatiPreg:: X Efek Samping: Diare, pruritus, pengingkatan sementara tes fungsi hati IO: Metildopa, kontrasepsi oral & obat hepatotoksikNama Dagang:Chenofalk

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 78: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexUrsodeoxycholic acidIndikasi:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 79: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAmino acidsI:Nutrisi parenteral esensial utk pasien insufisiensi hati kronik berat BSO: Infus 500ccD: 1-1,5 L/hr dg kecep infus 2cc/kg/jam atau 40 tts/mntKI: Koma hepatik endogen,atrofi hepatik akut, hiperkalemia, syok, dekompensasi kordis, intoleransi fruktosa atau sorbitol, defisiensi fruktosa 1,6-difosfat, keracunan metanol,kelainan metabolisme asam aminoP: ES: Preg:: A, B, C, D, X IO: Nama Dagang:Aminofusin Hepar

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 80: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexH. Preparat AnorektalMonoxerutinDiosmin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 81: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMonoxerutinI: Varises, hemoroidBSO: Kaps. 300 mgD: Awal 1 kaps 2x/hr. Pemeliharaan: 1 kaps/hrKI: P: Preg:: ES: Keluhan ringan lambungIO: Nama Dagang:Venaron

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 82: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDiosminI: Varises, insufisiensi vena, flebitis, hemoroidBSO: Tab 200mg, 500 mgD: Insufisiensi vena kronis 1 g/hrHemoroid akut: hr 1-4= 3g/hr, hr 5-7= 2g/hr, selanjutnya 1g/hr.

Hemoroid kronis: 1g/hr terbagi 1-3 dosisKI: HipersensitifP: Bumil, LaktasiPreg:: ES: Gangguan GI minorIO: Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 83: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexII. KARDIOVASKULER & SISTEM HEMATOPOIETIKA. A. CARDIAC DRUGB. ANTI ANGINAC. ACE INHIBITORD. Β BLOCKERE. CA ANTAGONISF. ANTAGONIS ANGIOTENSIN II & KOMBINASINYAG. DIURETIKH. ANTI HIPERTENSI LAINI. VASODILATOR PERIFER & CEREBRAL ACTIVATORJ. VASOCONTRICTORK. ANTI MIGRAINL. HEMOSTATIKM. ANTI KOAGULAN, ANTI THROMBUS & FIBRINOLITIKN. PREPARAT FLEBITIS & VARISESO. HEMOREOLOGIKP. HAEMATOPOIETIC AGENTQ. ANTI HIPOTENSIR.OBAT KARDIOVASKULER LAIN

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 84: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexA. Cardiac DrugDigoxinDobutaminDopamine HCl Isoprenaline HCMilrinonePrajmalium bitartrateAmiodaronelidocainePropafenone HCl

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 85: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDigoxin-- + inotropic effect. Effect is achieved via inhibition of the Na+/K+-ATPase pump, leading to increase in intracellular sodium concentration along with concomitant increase in intracellular calcium concentration by means of calcium-sodium exchange mechanism. Net result is augmentation of myocardial contractility.I: Gagal jantung, takikardi supraventrikulerBSO: Tab 0,25 mgD:Dws: Digitalisasi cepat (24-36 jam): 4-6 tab lalu 1 tab pd interval ttt smp kompensasi tercapai.Digitalisasi lambat (3-5 hr): 2-6 tab/hr dlm dosis terbagi.Penunjang: 1-3 tab/hrAnak <10th: Digitalisasi cepat : 25mcg/kg pd interval ttt smp kompensasi tercapai.Penunjang: 10-20 mcg/hr

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 86: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexKI: hypersensitivity; beriberi heart disease; idiopathic hypertrophic subaortic stenosis; constrictive pericarditis; carotid sinus syndromeIO: Increase digoxin levels: alprazolam, benzodiazepines, bepridil, captopril, cyclosporine, propafenone, propantheline, quinidine, diltiazem, aminoglycosides, oral amiodarone, anticholinergics, diphenoxylate, erythromycin, felodipine, flecainide, hydroxychloroquine, itraconazole, nifedipine, omeprazole, quinine, ibuprofen, indomethacin, esmolol, tetracycline, tolbutamide, and verapamil.Decrease serum digoxin levels: aminoglutethimide, antihistamines, cholestyramine, neomycin, penicillamine, aminoglycosides, oral colestipol, hydantoins, hypoglycemic agents, antineoplastic treatment combinations (eg, carmustine, bleomycin, methotrexate, cytarabine, doxorubicin, cyclophosphamide, vincristine, procarbazine), aluminum or magnesium antacids, rifampin, sucralfate, sulfasalazine, barbiturates, kaolin/pectin, and aminosalicylic acidPreg:C

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 87: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexP:Hypokalemia may reduce + inotropic effect of digitalis; IV calcium may produce arrhythmias in digitalized patients; hypercalcemia predisposes patient to digitalis toxicity; hypocalcemia can make digoxin ineffective until serum calcium levels are normal; magnesium replacement therapy must be instituted in patients with hypomagnesemia to prevent digitalis toxicity; patients diagnosed with incomplete AV block may progress to complete block when treated with digoxin; exercise caution in hypothyroidism, hypoxia, and acute myocarditis; adjust dose in renal impairment; highly toxic (overdoses can be fatal)Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 88: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDobutaminProduces vasodilation and increases inotropic state. At higher dosages may cause increased heart rate, exacerbating myocardial ischemia.I: Penunjang inotropik untuk Gagal JantungBSO: Amp. 12,5 mg/20ccVial 250 mg/10ccVial 50 mg/ccLar Infus 250 mg/ 5ccD: Awal 100-200 mcg/mnt IVInfus 2,5-10 mcg/kgBB/mnt. Dapat ditingkatkan hingga 40 mcg/kgBB/mnt.KI: Stenosis subaortik hipertrofik idiopatik, FeokromositomaP: Monitor kecepatan & irama denyutPreg:: BES: HipotensiIO: Nitroprussid, b-blocker menghambat efek DobutaminNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 89: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDopamine HClStimulates both adrenergic and dopaminergic receptors. I: Syok kardiogenik yng berhub dg infark myokard, septicemia endotoksik, trauma, gagal ginjal.BSO: Amp. 10 mg/cc, 20mg/cc, 40 mg/ccD: 2,5 mcg/kg/mnt dilarutkan dalam infuse IV. Dapat dinaikkan hingga 20-50 mg/kg/mnt.KI: Feokromositoma, takiaritmia atrial/ventrikulerP: Hipovolemia.Preg: C ES: Denyut ektopik, takikardia, nyeri angina, palpitasi.IO: Dipotensiasi oleh MAOI, FenotiazinNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 90: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIsoprenaline HClI: Blok jantung, serangan adam-stokes, henti jantung, bronkospasme dalam anestesi, hipoperfusi dan syokBSO: Inj 0,2 mg/ccD: Blok jantung, serangan adam-stokes, henti jantung: Dws:Bolus IV inj awal 0,02-0,06 mg, selanjutnya 0,01-0,2mg. Infus IV 5 mcg/mnt. IM awal 0,2 mg, selanjutnya 0,15-0,2mg.Intrakardiak 0,2mgBronkospasme dalam anestesi bolus inj: awal 0,01-0,02 mg. Hipoperfusi dan syok Dws: infus 0,5-5 mcg/mnt KI: Takiaritmia, takikardia atau blok jantung krn intoksikasi digitalis, aritmia ventrikuler yg membutuhkan terapi inotropik, angina pektorisP: PJK, insufisiensi koroner, syokkardiogenik, DM, hipertiroid, anestesi halotan. Perbaiki gangguan keseimbangan elektrolit dan hipovolemia sblm pemberian terapiPreg:: C

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 91: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexES: Kecemasan, pusing, sakit kepala, palpitasi, angina, serangan Adam-Stokes, edema pulmonal, hipertensi, hipotensi, aritmia ventrikuler, takiaritmia, flushing, berkeringatIO: Isoproterenol & epinefrin dpt menyebabkan aritmiaNama Dagang: Isuprel

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 92: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMilrinone+ inotropic agent and vasodilator. Results in reduced afterload, reduced preload, and increased cardiac output. Several studies comparing milrinone to dobutamine have demonstrated that milrinone showed greater improvements in preload and afterload and improvements in cardiac output, without significant increases in myocardial oxygen consumption.D:50 mcg/kg IV loading dose over 10 min, followed by continuous infusion at 0.25-1.0 mcg/kg/min; titrate to maintain adequate systolic blood pressure and cardiac outputKI:hypersensitivity; obstructive hypertrophic cardiomyopathyIO:Precipitates in presence of furosemidePreg: C P:Monitor fluids, electrolyte changes, and renal function during therapy; excessive diuresis may increase potassium loss and

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 93: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexpredispose digitalized patients to arrhythmias (correct hypokalemia with potassium supplementation prior to treatment); slow rates or stop infusion in patients showing excessive decreases in blood pressure; previous vigorous diuretic therapy has caused significant decreases in cardiac filling pressure; administer cautiously and monitor blood pressure, heart rate, and clinical symptomatologyNama Dagang:Coritrope

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 94: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPrajmalium bitartrateI: Takiaritmia tanpa gangguan konduksi AV,ekstra sistole yg tak tergantung pada penyebabnya kecuali pada bradikardia, sindrom WPW, pengobatan setelah elektrokonversi, pencegahan pada takikardia paroksismal, kateterisasi jantung.BSO: Tab 20 mg D: Awal 1 tab 3-4x/hr. Penunjang ½ tab 2-4x/hr. Pencegahan 1

tab 2x/hr. BB < 50kg dosisnya 1 mg/kg/hr.

KI: Gangguan konduksi AV & stimulus konduksi intraventrikuler, serangan Adam’s-Stokes.Bradiaritmia tmsk ekstrasistole dari denyut jantung yg lambat.P: Dekompensasi kordis. Bumil trim IPreg:: ES: Ikterus kolestatik,ggn penglihatanIO: Nama Dagang:Neo-Gilurytmal

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 95: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAmiodaroneDrug of choice: unstable ventricular arrhythmias. Currently considered a Class IIb intervention by the American Heart Association 2000 Emergency Cardiovascular Care Guidelines. Prehospital studies currently suggest that amiodarone is safe and efficacious for use in out-of-hospital cardiac arrest. Often used for life-threatening ventricular arrhythmias in patients who have relative KI: to its use.BSO: Tab 200 mg, Amp 150 mg/ccD:150 mg IV infused over 10 min, follow with 1 mg/min constant infusion for 6 h, then maintenance infusion at 0.5 mg/minOral dosing generally 400 mg/d following loadKI:hypersensitivity; sinus node dysfunction; atrioventricular conduction disorders; underlying hepatic, pulmonary, or thyroid diseaseIO:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 96: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIncreases effect and blood levels of theophylline, quinidine, procainamide, phenytoin, methotrexate, flecainide, digoxin, cyclosporine, beta-blockers, and anticoagulants; cardiotoxicity of amiodarone is increased by ritonavir, sparfloxacin, and disopyramide; coadministration with calcium channel blockers may cause an additive effect and decrease myocardial contractility further; cimetidine may increase amiodarone levelsPreg: C P: Hypotension, bradycardia, and AV block may occur; hypotension is most common adverse effect during IV administration; acute life-threatening pulmonary or hepatic toxicity may complicate acute or chronic use of this drug; elevation of serum hepatic enzymes and/or TSH requires that patients be monitored carefully during amiodarone therapy; rarely, irreversible blindness from optic neuritis is observed with chronic useNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 97: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLidocaine -- Class IB antiarrhythmic that increases electrical stimulation threshold of the ventricle, suppressing automaticity of conduction through the tissue. Although lidocaine may terminate VT successfully, it may increase the overall mortality in peri-infarction VT. Evidence for effectiveness is considered "Indeterminate" in the 2000 American Heart Association Emergency Cardiovascular Care guidelines.D: 1-1.5 mg/kg IV push, followed by 0.5-0.75 mg/kg IV push to a maximum of 3 mg/kg Continuous 1–4 mg/min infusion should be started after arrhythmia is suppressedPaed.Endotracheal, intraosseous, and IV loading dose: 1 mg/kg, may repeat twice at 10- to 15-min intervals if necessary; follow with continuous IV infusion of 20-50 mcg/kg/minKI: hypersensitivity to amide-type local anesthetics; avoid in Adams-Stokes syndrome and Wolf-Parkinson-White syndrome;

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 98: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexavoid in severe sinoatrial, atrioventricular (AV), or intraventricular block if artificial pacemaker not in placeIO: Coadministration with cimetidine or beta-blockers, increases toxicity of lidocaine; coadministration with procainamide and tocainide may result in additive cardiodepressant action; may increase effects of succinylcholinePreg: BP:Do not use a drug solution that contains preservatives; caution in heart failure, hepatic disease, hypoxia, hypovolemia or shock, respiratory-depression, and bradycardia; elderly patients may be at increased risk for CNS and cardiac adverse effects due to increased half-life or decreased clearance of the drug; high plasma concentrations can cause seizures, heart block, and AV conduction abnormalities; has been associated with malignant hyperthermia

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 99: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPropafenone HClPossibly works by reducing spontaneous automaticity and prolonging the refractory period.I: Fibrilasi/ Flutter atrium paroksismal, takikardia supraventrikuler paroksismal, aritmia ventrikulerBSO: Tab salut selaput 150 mgD: 150 mg PO q8h and increase at 3- to 4-d intervals up to 300 mg q8hKI: hypersensitivity; bronchospastic disorders; conduction disorders; bradycardia; uncontrolled heart failureIO: Decreases serum levels of rifampin; cimetidine, quinidine, warfarin, and beta-blockers may increase serum levels of propafenonePreg: CP: Should only be used for life-threatening arrhythmias; caution in patients with congestive heart failure, myocardial infarction, or hepatic or renal dysfunctionNama Dagang: Rytmonorm

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 100: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexB. Anti AnginaNitroglycerin/ Glyceryl trinitrateIsosorbideDipyridamoleTrimetazidine

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 101: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexShort-acting nitroglycerinsNitroglycerin/ Glyceryl trinitrate Causes relaxation of vascular smooth muscle by stimulating intracellular cyclic GMP production. Result is decrease in BP.I: Mengontrol hipertensi, angina pectorisBSO: amp 50 mg/10ccD: Jangan langsung IV, tapi larutkan dg NaCl 5% atau Glukosa 5%. Kadar maks 400mcg/cc.Titrasi awal 5 mcg/mnt, dpt dinaikkan 10 sampai 20 mcg/mnt. KI:hypersensitivity; severe anemia; shock; postural hypotension; head trauma; closed-angle glaucoma; cerebral hemorrhage; hypertrophic obstructive cardiomyopathyIO:Concurrent sildenafil (Viagra) may cause severe hypotension and death; aspirin may increase serum concentrations; calcium channel blockers may cause markedly symptomatic orthostatic hypotension (dose adjustment of either agent may be necessary)

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 102: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPreg: CP:Caution in coronary artery disease and low systolic BP; adverse effects include hypotension, flushing, headache, light-headedness, and tolerance (8- to 12-h nitrate-free interval is most effective method to prevent development of tolerance); high IV doses may cause methemoglobinemia, heparin resistance, and ethanol intoxication; ischemia may worsen upon withdrawal

Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 103: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLong-acting nitroglycerins IsosorbideRelaxes vascular smooth muscle by stimulating intracellular cyclic GMP. Decreases LV pressure (ie, preload) and arterial resistance (ie, afterload). Reduces cardiac oxygen demand by decreasing LV pressure and dilating arteries.I: BSO: Isosorbide dinitrate:Tab 5 mg, 10 mg, 20 mg, Tab sublingual 5 mgTab retard 20 mgIV 1 mg/ ccIsosorbide mononitrate:Tab salut 60 mgD: Isosorbide dinitrate:2.5-10 mg SL prn IR10-30 mg PO bid/tid SR80-120 mg PO qd IR (4x)Isosorbide mononitrate:10-20 mg PO bid SR30-120 mg PO qd

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 104: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexKI: Hipersensitif; severe anemia; closed-angle glaucoma; postural hypotension; head trauma; cerebral hemorrhageIO: Alcohol may cause severe hypotension and cardiovascular collapse; aspirin may increase serum concentrations and actions; calcium channel blockers may increase symptomatic orthostatic hypotension (adjust dose of either agent); may decrease effects of heparinPreg: CP: Tolerance to vascular and antianginal effects of nitrates may develop; minimize tolerance by using smallest effective dose or pulse therapy (intermittent dosing) or by alternating with other coronary vasodilators (take last daily dose of short-acting agent no later than 7 pm); caution when administering to patients with glaucoma Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 105: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDipyridamoleI: angina pektoris, ggn sirkulasi darah koroner, pasca infarkBSO: Tab 25 mg, 75 mg

D: 25-50 mg 2-3x/hr. KI: HipersensitifP: Jangan utk angina akut, stenosis aorta subvalvular, hemodinamik tak stabik karena MIES: Ggn GI, sakit kepalaIO: Derivat Xantin: teofilin & kafein menurunkan efek vasodilator. Aspirin menginduksi efek antitrombotikPreg:: BNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 106: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTrimetazidineI: Tambahan utk terapi anginaBSO: Tab salut selaput 35 mgD: 1 tab 2x/hrKI: Laktasi P: Gagal ginjal, gagal hati berat. Tidak utk serangan akut, angina tak stabil dan IM. BumilES: Ggn GI,muntahIO: Preg::

Nama Dagang: Trizedon MR

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 107: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexC. ACE InhibitorCaptopril Quinapril FosinoprilEnalaprilLisinoprilImidaprilTrandolaprilBenazeprilRamiprilPerindopril

Comparative studies show ACE inhibitors are more effective than other antihypertensives (ie, beta-blockers, calcium channel blockers) in reducing blood pressure and proteinuria, protecting renal function, and delaying onset of end-stage renal disease.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 108: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCaptoprilPrevents conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, resulting in lower aldosterone secretion.I:BSO: Tab 12,5 mg, 25 mg, 50 mg

D: Hypertension: 12.5-25 mg PO 2-3x; may increase by 12.5-25 mg/dose at 1- to 2-wk intervals; max 50 mg 3xCrCl 10-50 mL/min: give 75% of starting doseCrCl <10 mL/min: give 50% of starting doseCHF: 6.25-12.5 mg PO bid/tid; may increase by 12.5-25 mg/dose at 1- to 2-wk intervals; max 100 mg tidPaed.Neonates: 0.05-0.1 mg/kg/dose PO q6-24h; titrate dose up to 0.5 mg/kg/dose prnInfants: 0.15-0.3 mg/kg/dose PO q6-24h; titrate dose up; max 6 mg/kg/d in 2-4 divided doses prn

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 109: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexChildren: 0.3-0.5 mg/kg/dose PO q6-24h; titrate dose up; max of 6 mg/kg/d in 2-4 divided doses prnKI: Hipersensitif; renal impairmentIO:NSAIDs may reduce hypotensive effects of captopril; ACE inhibitors may increase digoxin, lithium, and allopurinol levels; rifampin decreases captopril levels; probenecid may increase captopril levels; the hypotensive effects of ACE inhibitors may be enhanced when given concurrently with diureticsPreg: C, DP:Caution in renal impairment, valvular stenosis, or severe congestive heart failure Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 110: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexQuinaprilCompetitive inhibitor of ACE. Reduce angiotensin II levels, decreasing aldosterone secretion.BSO: Tab 5 mg, 10 mg, 20 mgD: Hypertension: 10 mg PO 1-2x; increase to 80 mg/d prnCHF: 10 mg PO 1-2x; target dose is 20 mg PO bidKI: Hipersensitif; angioedemaIO: NSAIDs may reduce hypotensive effects of enalapril; ACE inhibitors may increase digoxin, lithium, and allopurinol levels; rifampin decreases enalapril levels; probenecid may increase enalapril levels; the hypotensive effects of ACE inhibitors may be enhanced when given concurrently with diureticsPreg: C, DP: Caution in renal impairment (serum creatinine >3.5), valvular stenosis, or severe congestive heart failure; watch for serum potassiumNama Dagang:Accupril

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 111: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFosinoprilCompetitive inhibitors of ACE. Reduce angiotensin II levels, decreasing aldosterone secretion.BSO: Tab 10 mgD:Hypertension: 10 mg/d PO; increase to 80 mg/d prnCHF: 10 mg/d PO; target dose is 40 mg/dKI: HipersensitifIO:NSAIDs may reduce hypotensive effects; may increase digoxin, lithium, and allopurinol levels; rifampin decreases levels; probenecid may increase levels; diuretics may exacerbate hypotensive effectsPreg: C, DP: Caution in renal impairment, valvular stenosis, severe CHFNama Dagang: Acenor

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 112: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexEnalaprilPrevents conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, resulting in increased levels of plasma renin and a reduction in aldosterone secretion.Helps control blood pressure and proteinuria. Decreases pulmonary-to-systemic flow ratio in the catheterization laboratory and increases systemic blood flow in patients with relatively low pulmonary vascular resistance. Has favorable clinical effect when administered over a long period. Helps prevent potassium loss in distal tubules. Body conserves potassium; thus, less oral potassium supplementation needed.BSO: Tab 5 mg,D:Hypertension: 2.5-5 mg/d PO; increase prn; dosing range is 10-40 mg/d PO 1-2x; alternatively, 1.25 mg/dose IV over 5 min q6hCHF: 2.5-5 mg/d PO; increase prn; dosing range is 10-40 mg/d PO 1-2xKI: Hipersensitif

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 113: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIO:NSAIDs may reduce hypotensive effects of enalapril; ACE inhibitors may increase digoxin, lithium, and allopurinol levels; rifampin decreases enalapril levels; probenecid may increase enalapril levels; the hypotensive effects of ACE inhibitors may be enhanced when given concurrently with diureticsPreg: C, DP:renal impairment, valvular stenosis, or severe congestive heart failure; IV formulation not recommended in managing neonatal hypertension because of risk of acute renal failure and oliguria Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 114: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLisinoprilPrevents conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, resulting in lower aldosterone secretion.BSO: Tab 5 mg, 10 mgD: Hypertension: 10 mg/d PO; increase 5-10 mg/d at 1- to 2-wk intervals; max 40 mgCHF: 10 mg/d PO; increase 5-10 mg/d at 1- to 2-wk intervals; target dose is 40 mg/dKI: HipersensitifIO: NSAIDs may reduce hypotensive effects of lisinopril; ACE inhibitors may increase digoxin, lithium, and allopurinol levels; rifampin decreases lisinopril levels; probenecid may increase lisinopril levels; the hypotensive effects of ACE inhibitors may be enhanced when given concurrently with diureticsPreg: C, DP: renal impairment, valvular stenosis, or severe congestive heart failure Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 115: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexImidaprilI: HipertensiBSO: Tab 5 mg, 10 mgD: Dws 5-10 mg 1x/hr. Pasien dg ggn ginjal, hipertensi berat atau hipertensi parenkim ginjal awal 2,5 mg/hrKI: Hipersensitif, pasien dalam pengobatan apheresi LDL menggunakan dextran selulosa sulfat. Pasien dialisis dengan acrylonitrilic methallyl sulfonat sodium membran (AN 69). Wanita atau wanita yang mungkin hamil.P: Hipertensi berat, hemodialisis, mendapat terapi diuretik, diet pembatasan garam secara ketat. Mengganggu kewaspadaan. Tak dianjurkan penggunaannya 1 jam sebelum operasi. Ggn ginjal berat. Stenosis arteri renal bilateral.ES: Ggn sist hematologi, albuminuria, peningkatan kreatinin BUN, sakit kepala, pusing, hipotensi postural, palpitasi, mual, muntah, nyeri perut, ruam, pruritus, batuk, rasa tidak enak pada faring, malaise, wajah kemerahan, kenaikan serum K, SGOT & SGPT

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 116: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIO: Dextran selulosa, AN 69, diuretik hemat K, HCT, triklormetiazid, litium, suplemen Ca, AINS (Indometasin)Preg: Nama Dagang: Tanapress

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 117: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTrandolaprilPrevent conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, resulting in lower aldosterone secretion.BSO: Tab 0.5 mg, 2 mgD: Hypertension: 1 mg/d PO; increase to 8 mg/d prnCHF: 1 mg/d PO; target dose is 4 mg/dKI: Hipersensitif; history of angioedemaIO:May increase digoxin, lithium, and allopurinol levels; probenecid may increase levels; diuretics or NSAIDs may increase hypotensive effectsPreg: C, DP: Caution in renal impairment, valvular stenosis, or severe CHF Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 118: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexBenazeprilPrevents conversion of angiotensin I to angiotensin II, which is a potent vasoconstrictor. Also causes lower aldosterone secretion=> reducing systemic & glomerular capillary pressure.BSO: Tab 5 mg, 10 mgD: 10 mg/d PO; increase to 80 mg/d prnKI: HipersensitifIO: NSAIDs may reduce hypotensive effects of benazepril; ACE inhibitors may increase digoxin, lithium, and allopurinol levels; rifampin decreases benazepril levels; probenecid may increase benazepril levels; the hypotensive effects of ACE inhibitors may be enhanced when given concurrently with diureticsPreg: C, DP: Caution in renal impairment, valvular stenosis, or severe congestive heart failureNama Dagang: Cibacen

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 119: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexRamipril Prevent conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, resulting in lower aldosterone secretion.BSO: Tab 2,5 mgD: Hypertension: 2.5 mg/d PO; increase to 20 mg/d prnCHF: 2.5 mg/d PO; target dose is 10 mg bidAngina: 2.5-5 mg PO qd; max 20 mg/dKI: Hipersensitif; history of angioedemaIO: May increase digoxin, lithium, and allopurinol levels; probenecid may increase levels; diuretics or NSAIDs may increase hypotensive effectsPreg: C, DP: Caution in renal impairment, valvular stenosis, or severe CHFNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 120: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPerindopril BSO: Tab 4 mgD: Hypertension: 4 mg/d PO; increase to 8 mg/d prnCHF: 2 mg/d PO; increase to 4 mg dosis tunggalKI: Hipersensitif; hamil,laktasiP: Caution in renal impairment, valvular stenosis, or severe CHFIO: Preg: C, DNama Dagang: Prexum

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 121: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexD. β BlockerPropranololAtenololMetoprololCarvedilolCarteololBisoprololSotalol

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 122: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPropranolol Nonselective beta-blocker that is lipophilic (penetrates CNS). I: Hipertensi, angina pectoris, ansietas takikardia, disaritmia, kardiomiopati obstruktif hipertrofi & tremor esensial.Terapi tambahan pada tirotoksikosis & feokromositoma. Profilaksis setelah IMA, migren & angina.BSO: Tab 10 mgD: Hipertensi , angina pectoris 20 mg 3-4x/hr, titrasi s/d 40 mg 3-4x/hr. IR: 40-160 mg PO bidSR: 60-320 mg PO qdKI: Hipersensitif; history of bronchospasm; uncompensated CHF; bradycardia; cardiogenic shock; AV conduction abnormalitiesIO: Aluminum salts, barbiturates, NSAIDs, penicillins, calcium salts, cholestyramine, and rifampin may decrease effects; calcium channel blockers, cimetidine, loop diuretics, and MAOIs may increase toxicity; may increase toxicity of hydralazine, haloperidol, benzodiazepines, and phenothiazines

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 123: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPreg: CP:Beta-adrenergic blockade may mask signs of acute hypoglycemia and hyperthyroidism; abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm; withdraw drug slowly and monitor closely; adverse effects include bronchial constriction, Raynaud phenomenon, hypotension, decreased libido, impotence, lethargy, depression, and decreased HDL; caution in Wolff-Parkinson-White syndrome and renal or hepatic dysfunction Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 124: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAtenololSelectively blocks beta1-receptors, with little/no effect on beta2 BSO: tab 50 mg, 100 mgD: HT= 50 mg PO qd; increase to 100 mg/d, if necessaryAngina= 50-200 mg PO qdPaed. 1-2 mg/kg/dose PO qdKI: Hipersensitif; congestive heart failure; pulmonary edema; cardiogenic shock; AV conduction abnormalities; heart block (without a pacemaker)IO: Coadministration with aluminum salts, barbiturates, calcium salts, cholestyramine, NSAIDs, penicillins, and rifampin may decrease effects; haloperidol, hydralazine, loop diuretics, and MAOIs may increase toxicity of atenololPreg: CP: Beta-adrenergic blockade may reduce symptoms of acute hypoglycemia and mask signs of hyperthyroidism; abrupt withdrawal may exacerbate symptoms of hyperthyroidism and cause thyroid storm; monitor patients closely and withdraw drug slowly; during an IV, carefully monitor BP, heart rate, and ECG

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 125: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMetoprololSelective beta1-adrenergic receptor blocker that decreases automaticity of contractions. During IV administration, carefully monitor blood pressure, heart rate, and ECG.BSO: Tab 50 mg, 100 mgD: Hypertension= 00 mg/d PO qd or divided bid/tid initially and increase at 1-wk interval prn to a total of 450 mg/d if necessaryAngina= 50-200 mg PO bidCHF= 100 mg PO qd; titrate to maximum dose of 400 mg/d PO in 1-2 divided doses.Paed.: 1-5 mg/kg/24h PO divided bidKI:Hipersensitif; uncompensated congestive heart failure; bradycardia; asthma; cardiogenic shock; AV conduction abnormalitiesIO:Aluminum salts, barbiturates, NSAIDs, penicillins, calcium salts, cholestyramine, and rifampin may decrease bioavailability and plasma levels of metoprolol, possibly resulting in decreased

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 126: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexpharmacologic effects; toxicity of metoprolol may increase with coadministration of sparfloxacin, phenothiazines, astemizole, calcium channel blockers, quinidine, flecainide, and contraceptives; metoprolol may increase toxicity of digoxin, flecainide, clonidine, epinephrine, nifedipine, prazosin, verapamil, and lidocainePreg: BP:Beta-adrenergic blockade may reduce signs and symptoms of acute hypoglycemia and may decrease clinical signs of hyperthyroidism; abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm; monitor patient closely and withdraw the drug slowly; during IV administration, carefully monitor blood pressure, heart rate, and ECG Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 127: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCarvedilolNonselective beta- and alpha-adrenergic blocker. Does not appear to have intrinsic sympathomimetic activity. May reduce cardiac output and decrease peripheral vascular resistance.BSO: Tab 6.25 mg, 25 mgD: 6.25 mg PO bid; start at 3.125 mg PO bid in heart failure, maintain for 1-2 wk if tolerated, and then increase to 12.5 mg bid; max 25 mg bidKI: Hipersensitif; hypotension; bradycardia; AV/SA node disease; cardiogenic shock; severe uncontrolled cardiac failureIO: Rifampin, barbiturates, cholestyramine, colestipol, NSAIDs, salicylates, and penicillins may decrease effects; may increase effects of antidiabetic agents, digoxin, and calcium channel blockers; clonidine may increase BP and decrease heart rate; may decrease effect of sulfonylureas; cimetidine, fluoxetine, paroxetine, and propafenone may increase levelsPreg: CP: CHF and in patients treated with digitalis, diuretics, or ACE inhibitors (AV conduction may be slowed); discontinue if liver

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 128: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indeximpairment occurs; caution in peripheral vascular disease, hyperthyroidism, and DM Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 129: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCarteololI: Angina pectoris, takikardia atau aritmia supraventrikuler, hipertensi esensial & neurosis jantungBSO: Tab 5 mgD: Dws awal 10-15 mg/hr terbagi dalam 2-3 dosis. Maks 30 mg dalam dosis terbagi.KI: Asma bronchial, kecenderungan bronkospasme, diabetic ketoasidosis & metabolic asidosis. Sinus bradikardi berat. Blok atrial gr 2 & 3. Blok sinus, koma, syok kardiogenik, gagal ventrikuler kanan sebagai kalanjutan dr hipertensi pulmonal. Ggl jantung kongestif. hamilP: Hipoglikemia idiopatik, DM tak terkontrol. Puasa lama. Ggn hati & ginjal. Ggn sirkulasi perifer. Manula, ibu menyusui. Penghentian terapi 24 jam sblm op, terapi dgn ß-blocker lain pd pasien feokromositomaES: Jarang, bradikardi, hipotensi, edema pada ekstremitas bawah,sakit kepala,pusing, nyeri ulu hati, mual, muntah, meteorismus, nyeri lambung, konstipasi, diare, erupsi dan gatal pd kulit, lemah, vertigo,lelah.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 130: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIO: Memperkuat obat hipoglikemik, antagonis Ca, simpatolitik, klonidin HClPreg:: C, D pd trim 2 &3 Nama Dagang: Mikelan

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 131: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexBisoprololSelectively blocks beta1 receptors, with little/no effect on beta2 BSO: Tab 2.5 mg, 5 mgD: 2.5-20 mg/d PO; max 40 mg/dKI: Hipersensitif; pulmonary edema; cardiogenic shock; AV conduction abnormalities; heart block (without pacemaker)IO: Aluminum salts, barbiturates, NSAIDs, penicillins, calcium salts, cholestyramine, and rifampin may decrease bioavailability and plasma levels, possibly resulting in decreased pharmacologic effects; sparfloxacin, phenothiazines, astemizole (recalled from US market), calcium channel blockers, quinidine, flecainide, and contraceptives may increase toxicity; may increase toxicity of digoxin, flecainide, clonidine, epinephrine, nifedipine, prazosin, verapamil, and lidocainePreg: CP: May reduce signs & symptoms of acute hypoglycemia & may decrease clinical signs of hyperthyroidism; abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm; monitor patient closely and withdraw drug slowly

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 132: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSotalol Primarily a potassium channel (IKr)–blocking drug, with weak beta-blocker effect. In ESVEM study, sotalol was compared with 6 other drugs (not including amiodarone) in VT patients. Survival was best in the sotalol group.BSO: Tab 80 mgD: 80-120 mg PO q12h initially; occasionally, doses as high as 240 mg q12h are used with careful monitoring for toxicityKI: Hipersensitif; complete AV block; intraventricular conduction defects; patients taking ritonavir or sparfloxacinIO: Increases effect of theophylline, quinidine, procainamide, phenytoin, methotrexate, flecainide, digoxin, cyclosporine, beta-blockers, and anticoagulants; cardiotoxicity of amiodarone is increased by ritonavir, sparfloxacin, and disopyramide; coadministration with calcium channel blockers may cause an additive effect and decrease myocardial contractility further; cimetidine may increase amiodarone levelsPreg: C

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 133: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexP: Risk of proarrhythmia increases with dose; monitor for QT prolongation, dyspnea, fatigue, depression, bradycardia, and syncope due to torsade de pointes

Nama Dagang:Sotacor

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 134: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexE. Ca AntagonisVerapamilDiltiazemAmlodipineNifedipineFelodipineLacidipine NicardipineLercanidipine

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 135: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexVerapamilDuring depolarization, inhibits calcium ions from entering slow channels and voltage-sensitive areas of vascular smooth muscle and myocardium.BSO: Tab/Kaps 80 mg, 240 mgD: HT= 240-480 mg/d PO divided tid/qidAngina= IR: 80-120 mg PO tid/qidSR: 120-240 mg PO qd/bid KI:Hipersensitif; severe CHF, sick sinus syndrome or second- or third-degree AV block, and hypotension (<90 mm Hg systolic)IO:Verapamil may increase carbamazepine, digoxin, and cyclosporine levels; coadministration with amiodarone can cause bradycardia and a decrease in cardiac output; may increase cardiac depression when administered concurrently with beta blockers; cimetidine may increase verapamil levels; verapamil may increase theophylline levelsPreg: C

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 136: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexP:Depresses impulse formation, AV block, - inotropism, and vasodilation, which can result in hypotension, shock, pulmonary edema, and death; hepatocellular injury may occur; transient elevations of transaminases with or without concomitant elevations in alkaline phosphatase and bilirubin have occurred (elevations have been transient and may disappear with continued verapamil treatment), monitor liver function; IV administration discouraged in neonates and young infants due to severe apnea, bradycardia, hypotension, and cardiac arrest periodically Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 137: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDiltiazemDuring depolarization, inhibit calcium ions from entering slow channels and voltage-sensitive areas of vascular smooth muscle and myocardium.I: angina pektorisBSO: Tab 30 mg, 60 mg

D: 30 mg 4x/hr. titrasi maks 360 mg/hr. ac & hs. KI: Hipersensitif; severe CHF; sick sinus syndrome; second- or third-degree AV block; hypotension (<90 mm Hg systolic); significant LV systolic dysfunctionIO: May increase carbamazepine, digoxin, cyclosporine, and theophylline levels; amiodarone may cause bradycardia and decrease in cardiac output; beta-blockers may increase cardiac depression; cimetidine may increase levelsPreg: CP: Caution in impaired renal or hepatic function; may increase LFT levels, and hepatic injury may occur Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 138: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAmlodipineRelax coronary smooth muscle and produce coronary vasodilation, which, in turn, improves myocardial oxygen delivery. Benefits nonPreg:nant patients with systolic dysfunction, hypertension, or arrhythmias. I: Hipertensi arterial, profilaksis angina pektorisBSO: Tab 5 mg, 10 mgD: HT= 2.5-5 mg PO 1x; max 10 mg/dAngina= 5-10 mg PO qdKI: HipersensitifIO: Fentanyl may increase hypotensive effects; may increase cyclosporine levels; H2 blockers (eg, cimetidine) may increase toxicityPreg: CP: Adjust dose in renal/hepatic impairment; may cause lower extremity edema; allergic hepatitis has occurred but is rare; caution in patients with severe LV systolic dysfunctionNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 139: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNifedipine-- Especially in the sustained-release form, nifedipine is a calcium channel blocker that has proven to be fairly effective in the management of chronic cor pulmonale caused by primary pulmonary hypertension. Modifies the entry of calcium into the cells by blocking the slow or voltage-dependent calcium channels, resulting in vasodilation, which improves myocardial oxygen delivery. Sublingual administration generally is safe, despite theoretical concerns.I: Insufiiensi jantung akut & kronik. Terapi tambahan hipertensiBSO: tab 5 mg, 10 mg D: 3x/d KI: Hipersensitif, pregnancyIO: Monitor oral anticoagulants when used concomitantly; coadministration with any agent that can lower BP, including beta-blockers and opioids, can result in severe hypotension; H2 blockers (cimetidine) may increase toxicityPreg: C

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 140: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexP: Aortic stenosis; angina; congestive heart failure; Preg:; nursing mothers; may cause lower extremity edema; allergic hepatitis has occurred but is rare Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 141: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFelodipineRelaxes coronary smooth muscle and produces coronary vasodilation, which in turn improves myocardial oxygen delivery. Benefits nonPreg:nant patients with systolic dysfunction, hypertension, or arrhythmias. Can be used during Preg: if indicated clinically.Calcium channel blockers potentiate ACE inhibitor effects. Renal protection is not proven, but these agents reduce morbidity and mortality rates in congestive heart failure. Calcium channel blockers are indicated in patients with diastolic dysfunction. Effective as monotherapy in black patients and elderly patients. BSO: tab 5 mgD: 5 mg PO qd; max 20 mg/dKI: HipersensitifIO: Fentanyl and alcohol may increase hypotensive effects; calcium channel blocker may increase cyclosporine levels; H2 blockers (cimetidine), erythromycin, nafcillin, and azole

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 142: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexantifungals may increase toxicity (avoid combination or monitor closely); carbamazepine may reduce bioavailability (avoid this combination); rifampin may decrease levels (monitor and adjust dose of calcium channel blocker)Preg: CP: Adjust dose in renal/hepatic impairment; may cause lower extremity edema; allergic hepatitis have occurred but is rareNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 143: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLacidipineI: HipertensiBSO: Tab 4 mgD: Awal 4 mg 1x/hr. titrasi 6 mg setelah 3-4 minggu. KI: Hipersensitif P: Ggn hati berat. Hamil,laktasi, nodus SA & AV abnormalES: Sakit kepala, muka kemerahan, edema, pusing, palpitasi, asthenia, ruam kulit, nyeri lambung, mual, poliuria, nyeri dada, hiperplasi ginggiva, alkalin fosfatase meningkat sementara.IO: Diuretik, β-blocker, menambah efek hipotensi. Cimetidin meningkatkatkan kadar obat dlm plasma. Preg:: Nama Dagang:Lacipil

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 144: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNicardipineA calcium channel blocker, inhibiting calcium ion influx into vascular smooth muscle and myocardium.BSO: Amp 2 mg, 10 mgD: Start 5 mg/h IV, increase by 2.5 mg/h q5-15min to a maximum of 15 mg/hKI: Hipersensitif; severe CHF; sick sinus syndrome; second- or third-degree AV block; hypotension (<90 mm Hg systolic)IO: May increase carbamazepine, digoxin, cyclosporine, and theophylline levels; when administered with amiodarone, may cause bradycardia and a decrease in cardiac output; when administered with beta-blockers, may increase cardiac depression; cimetidine may increase levelsPreg: CP: Caution in impaired renal or hepatic function; may increase LFTs, and hepatic injury may occur. Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 145: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLercanidipineI: Hipertensi esensial ringan-sedangBSO: Tab 10 mgD: 10 mg 1x/d, titrasi 20 mg/dKI: Hamil, laktasi, obstruksi aliran keluar ventrikel kiri. Ggl jantung kongestif, angina pectoris tak stabil, ggn hati/ ginjal berat. Digunakan dg siklosporin atau juz anggurP: sindroma sick sinus (jika tanpa pacu jantung), disfungsi ventrikel kiri,penykit jantung iskemik. Hindari penggunaan bersama inhibitor kuat CYP3A4 (spt ketokonazol)ES: Ruam, edema perifer, palpitasi, takikardi, sakit kepalaIO: Hindari penggunaan bersama inhibitor kuat CYP3A4 (spt ketokonazol, itrakonazol, ritonavir, eritromisin, rotreandomisin), siklosposrin, juz anggur. Hati-hati penggunaan dg substansi lain CYP3A4 (spt terfenadin, astemizol, obat anti aritmia kelas III), simetidin dosis tinggi, antikonvulsan dan rifampisin. Pemberian dosis tambahan jika obat bersama β-blocker.Nama Dagang: Zanidip

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 146: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexF. Antagonis Angiotensin II & KombinasinyaValsa rtan IrbesartanLosartanCandesartanTelmisartanOlmesartan medoxomil

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 147: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexValsartanProdrug that produces direct antagonism of angiotensin II receptors. Displaces angiotensin II from AT1 receptor and may lower blood pressure by antagonizing AT1-induced vasoconstriction, aldosterone release, catecholamine release, arginine vasopressin release, water intake, and hypertrophic responses. May induce more complete inhibition of renin-angiotensin system than ACE inhibitors, does not affect response to bradykinin, and is less likely to be associated with cough and angioedema. For use in patients unable to tolerate ACE inhibitors.I: Hipertensi, CHF NYHA II-IV, IMABSO: Tab 40 mg, 80 mg, 160 mgD: 80 mg PO qd; max 320 mg/dKI:Hipersensitif; severe hepatic insufficiency, biliary cirrhosis or obstruction, primary hyperaldosterism, bilateral renal artery stenosisIO:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 148: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMay increase digoxin, lithium, and allopurinol levels; probenecid may increase valsartan levels; coadministration with diuretics, increase hypotensive effects; NSAIDs may reduce hypotensive effects of valsartan; may increase risk of hyperkalemia if taken concurrently with potassium supplements or other potassium-sparing diureticsPreg: C, DP:Caution in hyperkalemia, suspected bilateral renal artery stenosis, or solitary kidney with unilateral RAS Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 149: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIrbesartanBlocks vasoconstrictor and aldosterone-secreting effects of angiotensin II at tissue receptor site. May induce more complete inhibition of renin-angiotensin system than ACE inhibitors and do not affect response to bradykinin (less likely to be associated with cough and angioedema).I: Hipertensi esensialBSO: Tab 150 mg, 300 mgD: 150 mg PO 1x qd; max 300 mg/dKI: Hipersensitif; hyperkalemiaP: Caution in patients with unilateral or bilateral renal artery stenosis; decrease dose in volume- or salt-depleted patients IO: May increase digoxin, lithium, and allopurinol levels; probenecid may increase irbesartan levels; coadministration with diuretics, increase hypotensive effects; NSAIDs may reduce hypotensive effects of irbesartan; may increase risk of hyperkalemia if taken with potassium -sparing diureticsPreg: C, DNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 150: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLosartan Nonpeptide angiotensin II receptor antagonists that block vasoconstrictor and aldosterone-secreting effects of angiotensin II at tissue receptor site. May induce more complete inhibition of renin-angiotensin system than ACE inhibitors and do not affect response to bradykinin (less likely to be associated with cough and angioedema).I: HipertensiBSO: Tab 50 mgD: 25-100 mg PO qd/bidKI: Hipersensitif; hyperkalemiaIO: Ketoconazole, sulfaphenazole, and phenobarbital may decrease effects; cimetidine may increase effectsPreg: C, DP: Caution in patients with unilateral or bilateral renal artery stenosis; decrease dose in volume- or salt-depleted patientsNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 151: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCandesartanBlocks vasoconstriction and aldosterone-secreting effects of angiotensin II. May induce more complete inhibition of renin-angiotensin system than ACE inhibitors, does not affect response to bradykinin, and is less likely to be associated with cough and angioedema. Use in patients unable to tolerate ACE inhibitors.Angiotensin II receptor blockers reduce blood pressure and proteinuria, protecting renal function, and delaying onset of end-stage renal disease.I: HipertensiBSO: Tab 8 mg, 16 mgD: 8-16 mg/d PO initially; max 32 mg/dKI: HipersensitifIO: May increase digoxin, lithium, and allopurinol levels; probenecid may increase candesartan levels; coadministration with diuretics, increase hypotensive effects; NSAIDs may reduce hypotensive effects of candesartan; may increase risk of

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 152: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexhyperkalemia if taken concurrently with potassium supplements or other potassium-sparing diureticsPreg: C, DP:Caution in renal impairment (serum creatinine >3.5), valvular stenosis, or severe congestive heart failure; watch for serum potassium Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 153: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTelmisartanI: Hipertensi esensialBSO: tab 40 mg, 80 mgD: Dws 40 mg 1x/hr. Max. 80 mg/hrKI: Hamil, laktasiP: Deplesi vol intravaskuler, ggl jantung kongestif berat, pnykit ginjal tmsk stenosis arteri ginjal, aldosteronisme primer, stenosis aorta atau mitral.ES: sakit kepala, pusing, nyeri, nyeri punggung, lelah, diare, gejala seperti flu, sinusitis, dyspepsia, batuk, nyeri dada, ISK.IO: Diuretik Hemat K, Suplemen K, bahan pengganti garam mengandung K atau obat lain yg dapat meningkatkan kadar K (heparin, digoksin, litium)Preg:: C, D pd trim 2 & 3Nama Dagang:Micardis

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 154: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexOlmesartanBlocks vasoconstrictor and aldosterone-secreting effects of angiotensin II at tissue receptor site. May induce more complete inhibition of renin-angiotensin system than ACE inhibitors and do not affect response to bradykinin (less likely to be associated with cough and angioedema).BSO: Tab 10 mg, 20 mg, 40 mgD: 20 mg PO qd; max 40 mg/dKI: HipersensitifIO: Diuretics may enhance hypotensive effectPreg: C, D P: May cause injury or even death to the developing fetus, due to effect on renin-angiotensin system, if given in second or third trimesters of Preg:; serum levels and AUC increase with renal and hepatic insufficiency respectively; may cause oliguria, azotemia, and acute renal failure; facial edema, angioedema, or decreased hemoglobin or hematocrit occur rarelyNama Dagang: Olmetec

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 155: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexG. DiuretikMannitolSpironolactoneFurosemideAcetazolamideHydrochlorothiazide/ HCTChlortalidoneIndapamide

Genghis Khun ([email protected]

FaiK Fauzi MuLaCheLLafaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 156: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMannitol-- Indicated for prophylaxis and treatment of pigment-induced renal failure secondary to rhabdomyolysis in those with cocaine poisoning, among others. Alternative diuretic used when urine output is inadequate despite aggressive fluid therapy.D: 1 g/kg of 20% solution IV over 20-30 minPaed.Initial dose: 0.5-1 g/kg/dose IVMaintenance dose: 0.25-0.5 g/kg/dose IV q4-6hKI: Hipersensitif; anuria; severe pulmonary congestion; progressive renal damage; severe dehydration; active intracranial bleeding; progressive heart failureIO: Effects can be potentiated by other diuretics (eg, furosemide, acetazolamide)Preg: CP: Carefully evaluate cardiovascular status before rapid administration of mannitol because a sudden increase in extracellular fluid may lead to fulminating CHF; avoid pseudoagglutination when blood is administered

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 157: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexsimultaneously, add at least 20 mEq of sodium chloride to each liter of mannitol solution; do not administer electrolyte-free mannitol solutions with blood; may crystallize with concentration above 20%; use in-line filter; may cause hypovolemia, headache, and polydipsia

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 158: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSpironolactoneUsed for management of hypertension. May block effects of aldosterone on arteriolar smooth muscles.BSO:D: Hypertension: 25-200 mg PO qd or divided bidCHF: 12.5 mg PO qd; max 25 mg/dPaed.1.5-3.5 mg/kg/d PO divided q6-24hKI:Hipersensitif; anuria; renal failure; hyperkalemiaIO:May decrease effect of anticoagulants; potassium and potassium-sparing diuretics may increase toxicityPreg: DP:Caution in renal and hepatic impairment Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 159: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFurosemide-- Example of diuretic agents used in the management of chronic cor pulmonale. Furosemide is a powerful loop diuretic that works on thick ascending limb of Henle loop, causing a reversible block in reabsorption of sodium, potassium, and chloride.D:20-80 mg/d PO/IV/IM; may titrate to maximum dose of 600 mg/dPaed.1-2 mg/kg/dose PO; max 6 mg/kg/dose; do not administer more frequent than q6h1 mg/kg IV/IM slowly under close supervision; max 6 mg/kgKI:Hipersensitif; hepatic coma; anuria; concurrent severe electrolyte depletionIO:Metformin decreases furosemide concentrations; furosemide interferes with hypoglycemic effect of antidiabetic agents and antagonizes muscle-relaxing effect of tubocurarine; auditory

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 160: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indextoxicity appears to be increased with coadministration of aminoglycosides and furosemide; hearing loss of varying degrees may occur; anticoagulant activity of warfarin may be enhanced when taken concurrently with this medication; increased plasma lithium levels and toxicity are possible when taken concurrently with this medicationPreg: CP:Perform frequent serum electrolyte, carbon dioxide, glucose, creatinine, uric acid, calcium, and BUN determinations during first few months of therapy and periodically thereafter Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 161: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAcetazolamideI: Glaukoma, epilepsy, ggl jantung kongestif & edema karena obatBSO: Tab 250 mgD: Glaukoma 250 mg-1 g/d dlm dosis terbagi. Epilepsi 8-30 mg/kg dlm dosis terbagi. Ggl jantung kongestif & edema karena= 250-375 mg 1x/d selama 1-2 hari.KI: Depresi Na &/ K serum, peny hati & ginjal, gagal kelenj suprarenal, asidosis hiperkloremik, sirosis. Penggunaan jangka panjang pd pasien glaucoma sudut tertutup non kongestifP: Obstruksi pulmoner atau emfisema. Hamil & laktasiES: Parestesia, ggn pendengaran/ tinnitus, perubahan rasa, ggn GI, poliuria, bingung, myopia sementara.IO: Preg: CNama Dagang:Diamox

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 162: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexHydrochlorothiazide/ HCTInhibits reabsorption of sodium in distal tubules, causing increased excretion of sodium and water as well as potassium and hydrogen ions.I: Edema, terapi tambahan hipertensiBSO: Tab 25 mg, 50 mgD: 25-100 mg PO qd; max 200 mg/kg/dPaed.<6 months: 2-3 mg/kg/d PO divided bid>6 months: 2 mg/kg/d PO divided bidKI: Hipersensitif; anuria or renal decompensationIO: May decrease effects of anticoagulants, antigout agents, and sulfonylureas; may increase toxicity of allopurinol, anesthetics, antineoplastics, calcium salts, loop diuretics, lithium, diazoxide, digitalis, amphotericin B, and nondepolarizing muscle relaxantsPreg: BP: Caution in renal disease, hepatic disease, gout, DM, and erythematosus

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 163: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexChlortalidoneInhibits reabsorption of sodium in distal tubules, causing increased excretion of sodium and water as well as potassium and hydrogen ions.I: Hipertensi arterial, esensial, nefrogenik, atau sistolik terisolasi.BSO: Tab 50 mgD: 25-100 mg/d POKI: Hipersensitif; anuria or renal decompensationIO: May decrease effects of anticoagulants, antigout agents, and sulfonylureas; may increase toxicity of allopurinol, anesthetics, antineoplastics, calcium salts, loop diuretics, lithium, diazoxide, digitalis, amphotericin B, and nondepolarizing muscle relaxantsPreg: B, D pd hipertensi yg diinduksi kehamilanP: Caution in renal disease, hepatic disease, gout, DM, and erythematosusNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 164: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIndapamideI: Hipertensi esensialBSO: tab lepas lambat 1.5 mgD: 1 tab/dKI: HipersensitifP: Hamil, laktasiES: Hipotensi ortostatik, hipokalemiaIO: Litium,obat non aritmik menyebabkan ledakan gelombang aritmia (astemizol, bepridil, eritromisin IV, halofantrin, pentamidin, sultoprid, terfenadin, vincamin)Preg:: B, D jika digunakan pd hipertensi yg diinduksi kehamilanNama Dagang:Natrilix SR

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 165: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexH. Anti Hipertensi LainSodium nitroprusside ClonidineDoxazosinReserpinBunazosin HClMethyldopaTerazosinMoxonidineHydralazine

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FB: facebook.com/mulachella

Page 166: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSodium nitroprussideI: Hipertensi krisis, control tensi selama anestesi utk mengurangi perdarahan pd op bedah. Terapi jangka pendek ggl jantungBSO: Amp 50 mg/ 5ccD: Administration requires the use of an infusion pump. Average dose: 5 mcg/kg/minute.Adults: I.V. Initial: 0.3-0.5 mcg/kg/minute; increase in increments of 0.5 mcg/kg/minute, titrating to the desired hemodynamic effect or the appearance of headache or nausea; usual dose: 3 mcg/kg/minute; rarely need >4 mcg/kg/minute; maximum: 10 mcg/kg/minute. When administered by prolonged infusion faster than 2 mcg/kg/minute, cyanide is generated faster than an unaided patient can handle.KI: Kondisi lemah, anemi tak terkoreksi,hipovolemi dimana sirkulasi otak tak mencukupi

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 167: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexP: Kerusakan ginjal, hati & serebrovaskuler. Kadar kobalamin plasma yg rendah. Leber’s optic atrophy, hipotiroidisme, ggn metabolisme sianida, hipotermia, stressES: Takikardi, hipotensi postural,mual, diaforesisIO: Efek hipotensif ditingkatkan oleh penghambat ganglion, obat antihipertensi, anestesi cair yg mudah menguap, zat yg mendepresisirkulasi.Preg: C Nama Dagang:Sodium nitroprusside DBL

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 168: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexClonidine Usually a third-line agent if other medications cannot be tolerated. Stimulates alpha2-adrenoreceptors in brain stem, activating an inhibitory neuron, which in turn results in reduced sympathetic outflow. These effects result in a decrease in vasomotor tone and heart rate.I: Hipertensi dan krisis hipertensi (obat ampul)BSO: Tab 0.075 mg, 0.15 mg. Amp 0.15 mg/cc D:Initial: 0.1 mg PO bidMaintenance: 0.2-1.2 mg/d bid/qid PO; max 2.4 mg/dAmp infuse IV dg kecepatan tak lebih dari 0.5 mcg/kg/mnt.Max 0.15 mcg/infuse, dpt diberikan 4x/d. KI: HipersensitifIO:TCAs inhibit hypotensive effects of clonidine; coadministration with beta-blockers may potentiate bradycardia; tricyclic antidepressants may enhance hypertensive response

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 169: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexassociated with abrupt clonidine withdrawal; narcotic analgesics enhance hypotensive effects of clonidinePreg: CP:Caution in cerebrovascular disease, coronary insufficiency, sinus node dysfunction, and renal impairment; abrupt discontinuation may lead to rebound hypertension Nama Dagang:Catapres

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 170: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDoxazosin I: Hipertensi, hyperplasia prostate jinakBSO: Tab 1 mg, 2 mgD: Hipertensi: awal 1 mg/hr selama 1-2 minggu. Titrasi 2 mg/hr pd 1-2 minggu selanjutnya, dst 4mg, 8 mg dg interval yg sama. Max 16 mg/hr.Hiperplasia prostat jinak: max 8 mg/hrKI: Hipersensitif P: Hipotensi postural/ sinkop, ggn fungsi hati. Hamil, laktasi. ES: Pusing, sakit kepala, letih, malaise, vertigo, asthenia, somnolenIO: Preg: CNama Dagang:Cardura

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 171: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexReserpinI: HipertensiBSO: Tab 0.1 mg, 0.25 mgD: 0.2-0.5 mg/hr terbagi dlm 2-3 dosis. Max 0.5mg/hrKI: Riwayat depresi, ulkus lambung aktif, colitis ulseratif, hamil, laktasiP: Aritmia jantung, IMA, kerusakan jantung berat, insufisiensi ginjal, batu empedu, epilepsy, asma bronchial, terapi elektrokonvulsi, anestesiES: Hidung tersumbat, kantuk, depresi, letargi, diareIO: Menghilangkan efek simpatomimetik indirek. Efek hipotensi ditingkatkan oleh tiazid & antihipertensi lain. Meningkatkan efek depresan SSP dr alcohol, analgesic, antihistamin, antidepresan trisiklik. Bersama MAOI menghasilkan eksitasi ringan & hipertensi. Digitalis atau Kuinidin meningkatkan efek aritmia jantungPreg: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 172: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexBunazosin HClI: Hipertensi esensial dan hipertensi akibat ggn ginjalBSO: Tab 1 mg

D: Dws Awal 1.5 mg/hr terbagi dlm 2-3 dosis. Max 3 mg/hr. KI: HipersensitifP: Hamil, laktasi, ggn hatiES: Ggn GI, takikardi, sinkop ortostatik, polakisuria, nokturiaIO: Diuretik & antihipertensi lainPreg: Nama Dagang:Detantol

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 173: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMethyldopaI: Hipertensi esensial ringan & berat. Hipertensi nefrogenik, hipertensi pada awal kehamilanBSO: Tab salut selaput 250 mgD: Awal 125 mg/hr. Titrasi tiap 2-3 hariKI: Hepatitis akut, sirosis hepatic atau riwayat penyakit hatiP: Riwayat penyakit hati & ggn mental. Disfungsi ginjal berat.ES: Lesu, mulut kering, Ggn GI, peningkatan BB, edema, impotensi.IO: Efek hipotensif dikurangi olehobat simpatomimetik, antidepresan trisiklik, fenotiazin & dipertinggi dg diuretic tiazid, alcohol, l-dopa, vasodilator. Mempotensiasi kerja hipoglikemik dr tolbutamidPreg:: B Nama Dagang:Dopamet

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 174: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTerazosin I: Hipertensi dan BPHBSO: Tab 1 mg, 2 mgD: Awal 1 mg 1x/hr sebelum tidur.Titrasi max 5 mg/hr.KI: P: Ggn dalam mengoperasikan mesinES: Ngantuk, mual, asthenia, hipotensi posturalIO: Preg:: CNama Dagang:Hytrin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 175: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMoxonidineI: Hipertensi primer ringan sedangBSO: Tab salut selaput 0.2 mg, 0.3 mgD: Awal 0.2 mg tiap pagi. Setelah 3 minggu titrasi 0.4 mg. Max 0.6 mg/hr & 0.4 mg/dosisKI: P: ES: IO: Preg: Nama Dagang:Physiotens

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 176: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexHydralazineIV form is useful when treating severe hypertension due to preeclampsia/eclampsia.D:10-20 mg/dose IV q4-6h prn initial; increase to 40 mg per dose prnBP >170/110 mm Hg: 0.1-0.2 mg/kg/dose IV q4-6h prn; max 20 mg or 1.7-3.5 mg/kg/d IV divided q4-6hKI: Hipersensitif; mitral valve rheumatic heart diseaseIO:MAOIs and beta-blockers may increase hydralazine toxicity; indomethacin may decrease pharmacologic effects of hydralazinePreg: BP:Hydralazine has been implicated in myocardial infarction; caution in suspected coronary artery disease Nama Dagang:Ser-ap-es (Hidralazine 25 mg, Reserpine 0.1 mg, HCT 15 mg)

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 177: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexI. Vasodilator Perifer & Cerebral ActivatorCiticolineFlunarizineGingkgo BilobaCo-dergocrine mesylateCinnarizineTocopheryl nicotinateNicergolineNicotinyl alcoholBuflomedilBencyclaneIsoxsuprine

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 178: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCiticolineI: Gangguan kesadaran yg menyertai cedera otak. Rehabilitasi ekstremitas inferior pd pasien hemiplegi apopleksiBSO: Tab 500 mg, 1 gAmp 125 mg/cc, 250 mg/2 cc, 500 mg/4 cc, 1 g/8ccD: Cedera Otak: 100-500 mg IV drip/inj IM/IV 1-2x/hr.Infark Serebral: 1 g IV 1x/hr selama 2 minggu .Hemiplegi apopleksi: 250 mg - 1 g IV/IO 1x/hr for 4 wksKI: P: ES: Hipotensi, diplopia, insomniaIO: Preg: Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 179: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFlunarizineI: Migren, pusing vestibuler & serebrovaskuler, Ggn sirkulasi perifer BSO: Tab 5 mg, 10 mgD: 10 mg/hr 1-2x/hrKI: Depresi, parkinsonisme, terapi beta blockerP: HamilES: IO: Preg: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 180: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexGingkgo BilobaI: Ggn peredaran darah otak & perifer dg manifestasi sakit kepala, vertigo, tinnitus, pikun, dementia, penurunan daya ingat, konsentrasi, emosi.BSO: Tab 40 mg, 50 mgD: 1 tab 3x/hrKI: HipersensitifP:ES: jarang, ggn pencernaanIO: Preg: Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 181: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCo-dergocrine mesylateI: Kemunduran mental krn usia lanjut, pusing, sakit kepala, disorientasi, lupa, depresiBSO: Tab 1 mg, 4.5 mg. Amp 0.3 mg/cc

D: 3-6 mg/hr 1-3x/hrAmp. 0.3 mg IV drip/ inj IV lambat/IM/SC 1-2x/hrKI: Psikosis akut & kronik P: Bradikardi berat, Hipotensi ortostatikES: Hidung tersumbat, ggn GIIO: Preg:: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 182: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCinnarizineI: Migren, ggn vestibuler & serebrovaskuler, ggn sirkulasi periferBSO: Tab 5 mg, 10 mgD: 10 mg/hr dosis tunggal malam hari/ terbagi, lama terapi max 6 bulan KI: Depresi, parkinsonisme, selama terapi β-blockerP: HamilES: Somnolen, fatiqueIO: Galaktorea bila digunakan dg kontrasepsi oralPreg: Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 183: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTocopheryl nicotinateI: Arteriosklerosis, apopleksi, insufisiensi koroner, ggn peredaran darah lain,kelainan metabolisme lemak.BSO: Kaps 100 mg

D: Dws Awal 2 kaps 3x/hr , pemeliharaan 1 kaps 1x/hrKI: P: Nafsu makan hilang, mual, diareES: IO: Preg: Nama Dagang: Enico

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 184: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNicergolineI: Ggn vaskulo-metabolik serebral akut & kronik (trombosis, emboli, ggn sirkulasi). Ggn vaskulo-metabolik perifer akut & kronik (obstruksi vaskuler pd ekstremitas, sindrom raynaud dll)BSO: Tab 10 mg, 30 mg D: 30-60 mg dlm 2-3 dosis terbagiKI: P: ES: Ggn GI ringan, sensasi panas pd wajah, kantuk. IO: Meningkatkan kerja antihipertensiPreg:Nama Dagang:Serolin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 185: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNicotinyl alcoholI: Vasospastik perifer tmsk pnykt Raynaud, gatal pd tangan & kaki, ulkus varikosaBSO: Tab 25 mgD: 1-2 tab 3-4x/hrKI: P: ES: IO: Preg: C Nama Dagang:Cetacol

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 186: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexBuflomedilI: Ggn serebrovaskuler & sirkulasi darah periferBSO: Tab salut selaput 150 mgD: 2-4 tab/hrKI: Jangan diberikan segera setelah partus atau jika terjadi perdarahan arteri parahP: singkirkan kemungkinan adanya delirium & demensia sekunder krn pnykt sistemik. Pnykt neurology primer, ggn fungsi ginjalES: Vertigo, sakit kepala, mual, pusingIO: Preg: Nama Dagang:Loftyl

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 187: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexBencyclaneI: Ggn sirkulasi serebral & perifer. Sklerosis vaskuler serebral. Arteriosklerotikal yg menginduksi ggn sirkulasi ekstremitas. Angiopati diabetic, ulkus kruris, pnykt Raynaud, akrosianosis, apopleksi & perdarahan subarakhnoid (setelah hari ke-4), pasca apopleksi. Penurunan pendengaran.BSO: Tab 100 mgD: 1 tab 3x/hr. kasus berat 2 tab 3x/hr.KI: Insufisiensi hati, ginjal & dekompensasi kordis,IMA, blok AV, apopleksi (s/d hari ke-3), kolaps sirkulasi berat, terapi simultan dg β-blocker P: Kejang otak, residu urin krn hipertrofi prostate.ES: Tab Ggn GI, Amp: IV, iritasi dinding pembuluh darah IO: Mempotensiasi aksi antihipertensi, nitrat, α-blocker, obat psikotropik trisiklikPreg: Nama Dagang: Fludilat

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 188: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIsoxsuprineI: to treat problems resulting from poor blood circulation.BSO: Tablet: 10 mg, 20 mgD: For poor blood circulation:Adults: 10-20 mg 3-4 times/day; start with lower dose in elderly due to potential hypotensionKI: Presence of arterial bleeding; do not administer immediately postpartumP: ES: 1% to 10%: Gastrointestinal: Nausea, vomitingIO: May enhance effects of other vasodilators/hypotensive agents; use with caution in elderlyPreg: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 189: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexJ. VasocontrictorNorephinephrine bitartrate

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 190: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNorepinephrine Naturally occurring catecholamine with potent alpha-receptor and mild beta-receptor activity. Stimulates beta1- and alpha-adrenergic receptors, resulting in increased cardiac muscle contractility, heart rate, and vasoconstriction. Increases blood pressure and afterload. Increased afterload may result in decreased cardiac output, increased myocardial oxygen demand, and cardiac ischemia. Generally reserved for use in patients with severe hypotension (eg, systolic blood pressure <70 mm Hg) or hypotension unresponsive to other medication.BSO: Amp 1 mg/cc, 4 mg/4cc, D: 0.5-1 mcg/min IV infusion initially, titrated to effect; max 30 mcg/minKI: Hipersensitif; obstructive hypertrophic cardiomyopathy; peripheral or mesenteric vascular thrombosis because ischemia may be increased and area of infarct extendedIO: Enhances pressor response of NE by blocking reflex bradycardia caused by NEPreg: C

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 191: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexP:May cause tachyarrhythmia (especially sinus tachycardia), increased myocardial oxygen demand, and cardiac ischemia; alkaline solutions may inactivate NE if administered through same IV line; extravasation may cause severe tissue necrosis, (administer into a large vein); if extravasation occurs, immediately infiltrate 5-10 mg of phentolamine (diluted in 10-15 mL of isotonic sodium chloride solution) to prevent necrosis; caution in occlusive vascular disease; if possible, correct blood-volume depletion before administration

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 192: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexK. Anti MigrainErgotamineDihydroergotamineSumatriptanPizotifen

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 193: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexErgotamineI: sakit kepala, migren, mual, vertigo,ggn usus, nyeri haid, hipermenore, ggn menopauseBSO: Tab 1 mgD: 1 tab 3x/hr, max 6 tab/hari atau 10 tab/mingguKI: Hamil, laktasi, kerusakan hati & ginjal, pembesaran prostatP: ES: IO: Preg: Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 194: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDihydroergotamineI: Hipotensi ggn sirkulasi ortostatik, baik primer/ sekunder krn terapi dg obat lainnya & gejala yg diakibatkannya spt pusing & lesu kronisBSO: Tab 2.5 mgD: 2.5 mg 2-3x/hr.Migren & sakit kepala: 2.5 mg 2x/hrKI: Hipersensitif P: ES: Kesemutan pd jari tangan dan kaki.IO: Erytromisin, troleandimisina atau josamisina meningkatkan kadar dihidroergotamin dlm darahPreg:: X Nama Dagang:Dihydergot (DHE)

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 195: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSumatriptanI: Migren akut, ‘cluster headache’ akutBSO: Tab 100 mgD: awal 100 mg, max 3 tab/hari, interval + 2 jamKI: Penyakit jantung iskemik, IMA, hipertensi tak terkendaliP : Hamil, laktasiES: IO: Ergotamin, terapi dg MAOI, litiumPreg: C Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 196: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPizotifenI: MigrenBSO: Tab 500 mcgD: Awal 0.5 mg/hr, titrasi s/d 1.5 mg/hr. sbg dosis tunggal malam hari atau 3x/hr. Profilaksis migren 0.5-3 mg/hrKI: Glaukoma sudut tertutup, retensi urineP: ES: IO: Meningkatkan efek sentral alcohol. Obat depresan SSP: efek adiktifPreg:Nama Dagang:Lysagor

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 197: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexL. HemostatikTranexamic acid Factor VIIIOctreotideCarbazochrome Na sulfonate SomatostatinEthamsylate

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 198: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTranexamic acidI: Perdarahan abnormal & gejala pnykt hemoragik spt hemoptisis, perdarahan abnormal selama operasiBSO: Tab 500 mg, Amp 250 mg/5 ccD: 1 tab 3-4x/hrKI: P: Ggn ginjal, trombosisES: Ggn GIIO: Preg: B Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 199: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFactor VIIII: Hemofilia A klasikBSO: Botol 250 iuD: Perdarahan Ringan & Profilaksis: 10 iu/kg dosis tunggalPerdarahan sedang: 15-25 iu/kg. bisa diulang 10-15 iu/kg 2-3x/hr.Perdarahan Berat: Awal 40-50 iu/kg.Pemeliharaan: 20-25 iu/kg tiap 8-12 jam.Pra-Op: 50 iu/kg.Hemostatik: infus se tiap 6-12 jam selama 10-14 hari sampai sembuh total.KI: Hipersensitif, defisiensi IgA selektifP: monitor tanda anemia progresif. HamilES: Alergi, kesemutan pd lengan, telinga & wajah. gemetarIO: Preg:: CNama Dagang:Koate-DIV

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 200: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexOctreotideI: Mengendalikan gejala pd Karsinoid metastatik & tumor yg sekresi peptide intestinal vasoaktif (VIPomas).Akromegali: Kurangi kadar GH & Somatomedin dlm plasma.Pasien sirosis: stop perdarahan pd Varises gastroesofagusBSO: amp 0.1/ccD: Tumor endokrin gastro-entero-pankreatik:Awal SC 0.05 mg 1-2x/hr, titrasi s/d 0.1-0.2 mg 3x/hr.Perdarahan varises gastro-esofagus: 25 mcg/jam IV selama 5 hari.KI: HipersensitifP: Insulinoma, diabetes, hamil, laktasiES: Reaksi local: nyeri, pedas, bengkak & merah.GI: Anoreksia,mual, muntah, nyeri kejang perut, meterismus, flatulensi, diare, steatore.Jarang: obstruksi intestinal akut, distensi abdominal progresif, nyeri epigastrium berat, nyeri tekan perut. Ggn toleransi glukosa Postprandial.Hepatitis akut tanpa kolestasis.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 201: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexHiperbilirubinemia disertai peningkatan fosfatase alkalin, gama glutamil transferase & transaminaseIO: Menurunkan absorbsi intestinal dr siklosporin. Menghambat absorbsi cimetidinPreg: BNama Dagang: Sandostatin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 202: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCarbazochrome Na sulfonateI: Mencegah & menghentikan perdarahan pada post op, pecahnya kapilerLeukopeni & trombositopeni krn radioterapi.BSO: Tab 10 mg, 100 mgD: 1-6 tab/hr dlm dosis terbagi 2-4xPerdarahan serebral krn hipertensi & arteriosclerosis: 90-120 mg/hr selama 3-4 minggu. Pemeliharaan 30 mg/hr.KI: HipersensitifP: ES: Nafsu makan hilang, dyspepsia.IO: Preg: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 203: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSomatostatinI: Terapi fistula intestinal & pancreas. Terapi simtomatik utk sekresi berlebihan pd tumor endokrin pd sal GI. Terapi perdarahan GI akut & berat yg diakibatkan oleh ulkus gaster atau duodenum, perdarahan gastritis & varises esophagus, perdarahan yg diketahui dg endoskopiBSO: Vial 250 mcg, 3 mgD: Awal 250 mcg bolus IV lambat > 1 menit. Diikuti infus IV 3.5 mcg/kg/jam (1 amp 3 mg) selama 12 jam. Pemberian terus menerus sebaiknya selama min 48 jam max 5 hari. KI: Hamil, laktasi, pra & post partumP: Hindari pemberian ulang, pantau ketat gula darahES: panas & kemerahan pd wajah, bradikardi, mual,nyeri abdomen, ggn kadar glukosa darah, hipertensi, hipotensiIO: Pemberian bersama glukosa & fruktosa pantau ketatPreg: BNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 204: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexEthamsylateI: Hemostatik-antihemoragikBSO: Tab 500 mg. Amp 250 mg/2ccD: Pencegahan & Terapi: 500 mg 3x/hrDarurat: 500 mg IV DAN IM. Pre-op: 500 mg 3x/hr, 2-3 jam pre-op. 1 jam pre-op 500 mg IV/IM.Selama operasi: 1 g dalam infuse.Post op: 500 mg IV/IM 2x/hr atau 1 tab 3x/hr, selama 4 hari.KI:P: ES: Kadang mual, sakit kepala, ruam kulit, hipotensiIO: Preg: Nama Dagang:Dicynone

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 205: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexM. Anti koagulan, anti thrombus & Fibrinolitik (Trombolitik)StreptokinaseTiclopidine HClHeparin sodiumWarfarinEnoxaparinAprotinin Acetylsalicyclic acid/ AspirinClopidogrelNadroparin calciumIloprostCilostazolFondaparinux sodiumAntithrombin IIIAnagrelideAlteplase

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 206: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexStreptokinase-- Acts with plasminogen to convert plasminogen to plasmin. Plasmin degrades fibrin clots as well as fibrinogen and other plasma proteins. Increase in fibrinolytic activity that degrades fibrinogen levels for 24-36 h takes place with IV infusion of streptokinase. Absorbed from the pleural space.BSO: Vial 1.500.000 iuD: 250,000 IU IV in 100 mL of isotonic sodium chloride solution qd or bid is instilled into pleural space for 3-5 dKI: Hipersensitif; active internal bleeding; intracranial neoplasm; aneurysm; diathesis; severe uncontrolled arterial hypertensionIO: Antifibrinolytic agents may decrease effects of streptokinase; heparin, warfarin, and aspirin may increase risk of bleedingPreg: BP: Caution in severe hypertension, IM administration of medications, trauma, or surgery in the previous 10 d; measure hematocrit, platelet count, aPTT, TT, PT, or fibrinogen levels before therapy is implemented; either TT or aPTT should be

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 207: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexless than twice the reference range value following infusion of streptokinase and before instituting or reinstituting heparin; do not take blood pressure in the lower extremities because it may dislodge a possible deep vein thrombus; PT, aPTT, TT, or fibrinogen should be monitored 4 h after the initiation of therapyNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 208: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTiclopidine HClAntiplatelet AgentI: Prevents strokes. Other uses include protection of bypass grafts in the heart, protection of stents in the heart, reduction of graft loss after kidney transplant, and prevention of blood clots.BSO: Tab 250 mg

D: 250 mg 1-2x/hr KI: HipersensitifP: > 65 or older, a blood problem or low blood counts, taking phenytoin, cyclosporine, or theophylline. stomach ulcer or bleeding, bleed easily, Avoid other aspirin-containing products, such as, ibuprofen or like products, other blood thinners (warfarin, ticlopidine, clopidogrel), garlic, ginseng, ginkgo, vitamin E, allergic to any medicine, pregnancy, breast-feeding.ES: Nausea or vomiting. Diarrhea, Belly pain, heartburn, Stomach bleeding or ulceration.Preg:: B Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 209: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexHeparin sodiumI: Prophylaxis and treatment of thromboembolic disordersPregnancy Risk FactorBSO: Lock flush injection: Beef lung source: 10 U/mL; 100 U/mL Porcine intestinal mucosa source: 10 U/mL; 100 U/mL Multiple-dose vial injection: Beef lung source, with preservative: 1000 U/mL; 5000 U/mL; 10,000 U/mL; 20,000 U/mL; 40,000 U/mL Porcine intestinal mucosa source, with preservative: 1000 U/mL; 5000 U/mL; 10,000 U/mL; 20,000 U/mL Single-dose vial injection: Beef lung source: 1000 U/mL; 5000 U/mL; 10,000 U/mL; 20,000 U/mL; 40,000 U/mL Porcine intestinal mucosa: 1000 U/mL; 5000 U/mL; 10,000 U/mL; 20,000 U/mL; 40,000 U/mL Unit dose injection:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 210: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPorcine intestinal mucosa source, with preservative: 1000 U/dose; 2500 U/dose; 5000 U/dose; 7500 U/dose; 10,000 U/dose; 15,000 U/dose; 20,000 U/dose Heparin sodium infusion, porcine intestinal mucosa source: D5W: 40 U/mL; 50 U/mL; 100 U/mL NaCl 0.45%: 2 U/mL); 50 U/mL; 100 U/mL NaCl 0.9%: 2 U/mL; 5 U/mL; 50 U/mL Heparin calcium: Unit dose injection, porcine intestinal mucosa, preservative free: 5000 U/dose; 12,500 U/dose; 20,000 U/dose D: Line flushing: When using daily flushes of heparin to maintain patency of single and double lumen central catheters, 10 U/mL is commonly used for younger infants (eg, <10 kg) while 100 U/mL is used for older infants, children, and adults. Capped PVC catheters and peripheral heparin locks require flushing more frequently (eg, every 6-8 hours). Volume of heparin flush is usually similar to volume of catheter (or slightly greater). Additional flushes should be given when stagnant

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 211: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexblood is observed in catheter, after catheter is used for drug or blood administration, and after blood withdrawal from catheter.Addition of heparin (0.5-1 unit/mL) to peripheral and central TPN has been shown to increase duration of line patency. The final concentration of heparin used for TPN solutions may need to be decreased to 0.5 U/mL in small infants receiving larger amounts of volume in order to avoid approaching therapeutic amounts. Arterial lines are heparinized with a final concentration of 1 unit/mL.Children:Intermittent I.V.: Initial: 50-100 U/kg, then 50-100 U/kg q4 hoursI.V. infusion: Initial: 50 U/kg, then 15-25 U/kg/hour; increase dose by 2-4 U/kg/hour every 6-8 hours as requiredAdults:Prophylaxis (low-dose heparin): S.C.: 5000 U every 8-12 hoursIntermittent IV: 1st 10,000 U, then 50-70 U/kg (5000-10,000 U) every 4-6 hoursI.V. infusion: 50 U/kg to start, then 15-25 U/kg/hour as continuous infusion; increase dose by 5 U/kg/hour every 4

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 212: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexhours as required according to PTT results, usual range: 10-30 U/hourWeight-based protocol: 80 U/kg I.V. push followed by continuous infusion of 18 U/kg/hour. Using a Standard Heparin Solution (25,000 U/500mL D5W), the following infusion rates can be used to achieve the listed doses.KI: Hypersensitivity, severe thrombocytopenia; uncontrolled active bleeding except when due to DIC; suspected intracranial hemorrhage; not for I.M. use; not for use when appropriate monitoring parameters cannot be obtainedP: Hipersensitif reaction and only in life-threatening situations. Hemorrhage is the most common complication. Monitor for signs and symptoms of bleeding. Certain patients are at increased risk of bleeding. Risk factors include bacterial endocarditis; congenital or acquired bleeding disorders; active ulcerative or angiodysplastic GI diseases; severe uncontrolled hypertension; hemorrhagic stroke; or use shortly after brain, spinal, or ophthalmology surgery; patient treated concomitantly with platelet inhibitors; conditions associated with increased

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 213: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexbleeding tendencies (hemophilia, vascular purpura); recent GI bleeding; thrombocytopenia or platelet defects; severe liver disease; hypertensive or diabetic retinopathy; or in patients undergoing invasive procedures. A higher incidence of bleeding has been reported in patients >60 years of age, particularly women. They are also more sensitive to the dose.Some preparations contain benzyl alcohol as a preservative. In neonates, large amounts of benzyl alcohol (>100 mg/kg/day) have been associated with fatal toxicity (gasping syndrome). The use of preservative-free heparin is, therefore, recommended in neonates. Some preparations contain sulfite which may cause allergic reactions.Heparin does not possess fibrinolytic activity and, therefore, cannot lyse established thrombi; discontinue heparin if hemorrhage occurs; severe hemorrhage or overdosage may require protamineES: bleeding is the major adverse effect of heparin. Fever, headache, chills, Unexplained bruising, urticaria, alopecia, dysesthesia pedis, purpura, eczema, Hyperkalemia

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 214: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index(supression of aldosterone), rebound hyperlipidemia on discontinuation, Nausea, vomiting, constipation, hematemesis, Frequent or persistent erection, Hemorrhage, blood in urine, bleeding from gums, epistaxis, adrenal hemorrhage, ovarian hemorrhage, retroperitoneal hemorrhage, thrombocytopenia, Elevated liver enzymes (AST/ALT), Irritation, ulceration, cutaneous necrosis have been rarely reported with deep S.C. injections, I.M. injection (not recommended) is associated with a high incidence of these effects, Peripheral neuropathy, osteoporosis (chronic), Hemoptysis, pulmonary hemorrhage, asthma, rhinitis, Conjunctivitis, anaphylactoid reactionsNote: Thrombocytopenia has been reported to occur at an incidence between 0-30%. It is often of no clinical significance. However, immunologically mediated heparin-induced thrombocytopenia has been estimated to occur in 1-2% of patients, and is marked by a progressive fall in platelet counts and, in some cases, thromboembolic complications (skin necrosis, pulmonary embolism, gangrene of the extremities, stroke or myocardial infarction); daily platelet counts for 5-7

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 215: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexdays at initiation of therapy may help detect the onset of this complication. Case reports: Bronchospasm, erythematous plaquesIO: increase the risk of hemorrhage: Cephalosporins which contain the MTT side chain, aspirin, NSAIDs, dipyridamole, ticlopidine, clopidogrel.Nitroglycerin (I.V.) may decrease heparin's anticoagulant effect. This interaction has not been validated in some studies, and may only occur at high nitroglycerin dosages.Penicillins (parenteral) may prolong bleeding time via inhibition of platelet aggregation, potentially increasing the risk of hemorrhage. Warfarin: Risk of bleeding may be increased during concurrent therapy. Heparin is commonly continued during the initiation of warfarin therapy to assure anticoagulation and to protect against possible transient hypercoagulability.Other drugs reported to increase heparin's anticoagulant effect include antihistamines, tetracycline, quinine, nicotine, and cardiac glycosides (digoxin).Preg: C

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 216: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexWarfarinAnticoagulant. Prophylaxis and treatment of venous thrombosis, pulmonary embolism, and thromboembolic disorders.D: 2-10 mg/d PO/IV qd; adjust dose to an INR of 1.5:2 or higher depending on the condition requiring anticoagulationPaed.0.05-0.34 mg/kg/d PO/IV; adjust dose according to desired INRKI:Hipersensitif; severe liver or kidney disease; open wounds; GI ulcersIO:Griseofulvin, carbamazepine, glutethimide, estrogens, nafcillin, phenytoin, rifampin, barbiturates, cholestyramine, colestipol, vitamin K, spironolactone, oral contraceptives, and sucralfate may decrease anticoagulant effects; oral antibiotics, phenylbutazone, salicylates, sulfonamides, chloral hydrate, clofibrate, diazoxide, anabolic steroids, ketoconazole, ethacrynic acid, miconazole, nalidixic acid, sulfonylureas, allopurinol, chloramphenicol, cimetidine, disulfiram,

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 217: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexmetronidazole, phenylbutazone, phenytoin, propoxyphene, sulfonamides, gemfibrozil, acetaminophen, and sulindac may increase anticoagulant effectsPreg: DP:Dose needs to be adjusted to INR; caution in bleeding tendency and hazardous active hemorrhagic conditions, malignant hypertension, patients at high risk of recurrent trauma, (eg, people with alcoholism or psychosis, unsupervised patients who are senile); warfarin anaphylaxis, hepatic, renal, thyroid, allergic, and hematologic hypocoagulable conditions and disorders; do not switch brands after achieving therapeutic response; caution in active tuberculosis or diabetes; patients with protein C or S deficiency are at risk of developing skin necrosis Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 218: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexEnoxaparinI: Prevention of deep vein thrombosis following hip or knee replacement surgery or abdominal surgery in patients at risk for thromboembolic complications; inpatient treatment of acute deep vein thrombosis with and without pulmonary embolism when administered in conjunction with warfarin sodium; outpatient treatment of acute deep vein thrombosis without pulmonary embolism when administered in conjunction with warfarin sodium; prevention of ischemic complications of unstable angina and non-Q wave myocardial infarction (when administered with aspirin)BSO: Injection:Graduated prefilled syringe: 60 mg/0.6 mL, 80 mg/0.8 mL, 100 mg/1.0 mLAmpul: 30 mg/0.3 mLD: S.C.: Adults:DVT prophylaxis in hip replacement:30 mg twice daily: First dose within 12-24 hours after surgery and every 12 hours until risk of deep vein thrombosis has

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 219: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexdiminished or the patient is adequately anticoagulated on warfarin. Average duration of therapy: 7-10 days.40 mg once daily: First dose within 9-15 hours before surgery and daily until risk of deep vein thrombosis has diminished or the patient is adequately anticoagulated on warfarin. Average duration of therapy: 7-10 days unless warfarin is not given concurrently, then 40 mg S.C. once daily should be continued for 3 more weeks (4 weeks total).DVT prophylaxis in knee replacement:30 mg twice daily: First dose within 12-24 hours after surgery and every 12 hours until risk of deep vein thrombosis has diminished. Average duration of therapy: 7-10 days; maximum course: 14 days.Patients who weigh <100 lb or are >65 years of age: Some clinicians recommend 0.5 mg/kg/dose every 12 hours to reduce the risk of bleeding.DVT prophylaxis in high-risk patients undergoing abdominal surgery: 40 mg once daily, with initial dose given 2 hours prior

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 220: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexto surgery; usual duration: 7-10 days and up to 12 days has been tolerated in clinical trials.Treatment of acute proximal DVT: Start warfarin within 72 hours and continue enoxaparin until INR is between 2.0 and 3.0 (usually 7 days).Inpatient treatment of DVT with or without pulmonary embolism: Adults: S.C. 1 mg/kg/dose every 12 hours or 1.5 mg/kg once daily.Outpatient treatment of DVT without pulmonary embolism: Adults: S.C.: 1 mg/kg/dose every 12 hours.Prevention of ischemic complications with unstable angina or non-Q-wave myocardial infarction: S.C.: 1 mg/kg twice daily in conjunction with oral aspirin therapy (100-325 mg once daily); treatment should be continued for a minimum of 2 days and continued until clinical stabilization (usually 2-8 days).Dosing adjustment in renal impairment: Total clearance is lower and elimination is delayed in patients with renal failure; adjustment may be necessary in elderly and patients with severe renal impairment.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 221: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexHemodialysis: Supplemental dose is not necessary.Peritoneal dialysis: Significant drug removal is unlikely based on physiochemical characteristics.KI: Hypersensitivity to enoxaparin or thrombocytopenia associated with a + in vitro test for antiplatelet antibodies in the presence of enoxaparin; hypersensitivity to pork products; active major bleeding; not for I.M. or I.V. useP: Patients with recent or anticipated neuraxial anesthesia (epidural or spinal anesthesia) are at risk of spinal or epidural hematoma and subsequent paralysis. Consider risk versus benefit prior to neuraxial anesthesia; risk is increased by concomitant agents which may alter hemostasis, as well as traumatic or repeated epidural or spinal puncture. Patient should be observed closely for bleeding if enoxaparin is administered during or immediately following diagnostic lumbar puncture, epidural anesthesia, or spinal anesthesia.ES: As with all anticoagulants, bleeding is the major adverse effect of enoxaparin. Hemorrhage may occur at virtually any site. Risk is dependent on multiple variables. At the

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 222: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexrecommended doses, single injections of enoxaparin do not significantly influence platelet aggregation or affect global clotting time (ie, PT or APTT).Central nervous system: Fever (5% to 8%), confusion, painDermatologic: Erythema, bruisingGastrointestinal: Nausea (3%), increased ALT/AST (5.9% to 6.1%)Hematologic: Hemorrhage (5% to 13%), thrombocytopenia (2%), hypochromic anemia (2%)Local: Injection site hematoma (9%), local reactions (irritation, pain, ecchymosis, erythema)IO: Drugs which affect platelet function (eg, aspirin, NSAIDs, dipyridamole, ticlopidine, clopidogrel) may potentiate the risk of hemorrhage.Thrombolytic agents increase the risk of hemorrhage.Warfarin: Risk of bleeding may be increased during concurrent therapy. Enoxaparin is commonly continued during the initiation of warfarin therapy to assure anticoagulation and to protect against possible transient hypercoagulability.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 223: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexStandard heparin consists of components with molecular weights ranging from 4000-30,000 daltons with a mean of 16,000 daltons. Heparin acts as an anticoagulant by enhancing the inhibition rate of clotting proteases by antithrombin III impairing normal hemostasis and inhibition of factor Xa. Low molecular weight heparins have a small effect on the activated partial thromboplastin time and strongly inhibit factor Xa. Enoxaparin is derived from porcine heparin that undergoes benzylation followed by alkaline depolymerization. The average molecular weight of enoxaparin is 4500 daltons which is distributed as ( less than or equal to 20%) 2000 daltons, ( greater than or equal to 68%) 2000-8000 daltons, and ( less than or equal to 15%) >8000 daltons. Enoxaparin has a higher ratio of antifactor Xa to antifactor IIa activity than unfractionated heparin.Preg: B Nama Dagang: Lovenox

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 224: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAprotininI: Reduction or prevention of blood loss in patients undergoing coronary artery bypass surgery when a high risk of excessive bleeding exists, including open heart reoperation, pre-existing coagulopathies, operations on the great vessels, and when a patient's beliefs prohibit blood transfusionsBSO: Injection: 1.4 mg/mL [10,000 U/mL] D: Test dose: All patients should receive a 1 mL I.V. test dose at least 10 minutes prior to the loading dose to assess the potential for allergic reactions Regimen A (standard dose): 2 million U (280 mg) loading dose I.V. over 20-30 minutes 2 million U (280 mg) into pump prime volume 500,000 U/hour (70 mg/hour) I.V. during operation Regimen B (low dose): 1 million U (140 mg) loading dose I.V. over 20-30 minutes 1 million U (140 mg) into pump prime volume 250,000 U/hour (35 mg/hour) I.V. during operation KI: Hypersensitivity to aprotinin or any component

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 225: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexP: Anaphylactic reactions are possible. Hypersensitivity reactions are more common with repeated use especially when re-exposure is within 6 months. All patients should receive a test dose at least 10 minutes before loading dose. Patients with a history of allergic reactions to drugs or other agents may be more likely to develop a reaction.ES: 1-10%: Atrial fibrillation, myocardial infarction, heart failure, atrial flutter, ventricular tachycardia, hypotension, supraventricular tachycardia, Fever, mental confusion, Phlebitis, Dyspnea, bronchoconstriction IO: Heparin and aprotinin prolong ACT. The ACT becomes a poor measure of adequate anticoagulation with the concurrent use of these drugs. Fibrinolytic drugs may have poorer activity. Aprotinin blocks this fibrinolytic activity; avoid concurrent use. Captopril's antihypertensive effects may be blocked; avoid concurrent use. Preg:B Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 226: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAcetylsalicyclic acid/ AspirinPrevents platelet aggregation by irreversible cyclooxygenase inhibition with subsequent suppression of thromboxane A2. Antiplatelet effect can last as long as 7 d.BSO: D: 81-325 mg PO qdKI:Hipersensitif; liver damage; hypoprothrombinemia; vitamin K deficiency; bleeding disorders; asthmaBecause of association with Reye syndrome, do not use in children ( <16 y) with fluIO:Antacids and urinary alkalinizers may decrease effects; corticosteroids decrease salicylate serum levels; anticoagulants may cause additive hypoprothrombinemic effects and increased bleeding time; may antagonize uricosuric effects of probenecid and increase toxicity of phenytoin and valproic acid; doses > 2 g/d may potentiate glucose-lowering effect of sulfonylurea drugsPreg: D

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 227: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexP:May cause transient decrease in renal function and aggravate chronic kidney disease; avoid use in patients with severe anemia, history of blood coagulation defects, or taking anticoagulants; adverse effects include prolonged bleeding time, rhinitis, asthma, urticaria, and exacerbation of gout; monitor BP, BUN, and uric acid level; consider discontinuing 7 d before surgery Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 228: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexClopidogrelSelectively inhibits ADP binding to platelet receptor and subsequent ADP-mediated activation of GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Consider in patients with contraindication to aspirin.D: 75 mg PO qdKI: Hipersensitif; active pathological bleedingIO: Naproxen associated with increased occult GI blood loss; prolongs bleeding time; safety of coadministration with warfarin not establishedPreg: CP: Caution in patients at increased risk of bleeding from trauma, surgery, or other pathological conditions; caution in patients with lesions with propensity to bleed (eg, ulcers); adverse effects include rash, diarrhea, purpura, GI ulcers, neutropenia, and rare cases of agranulocytosis; consider discontinuing 7 d before surgery Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 229: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNadroparin calciumI: Ggn tromboembolik, mencegah pembekuan darah.BSO: Jarum suntik Prefilled 9.500 anti-Xa/ccD: 0.3 cc 1x/hr (7.500 ICU AXa) selama min 7 hari. Pre-op: 2-4 jam sebelum.Bedah ortopedi: 12 jam pre-op & 12 jam post-opBB 50-69 Kg: 0.3 cc pre-op s/d hr ke-3. 0.4 cc harike-4 dst.BB < 50 Kg: 0.2 cc pre-op s/d hr ke-3. 0.3 cc harike-4 dst. Terapi minimal 10 hari.Mencegah pembekuan darah selama hemodialisis:BB 50-69 Kg: 0.4 cc.BB < 50 Kg: 0.3 cc .KI: TrombositopeniP: ES: IO: OAINS, Aspirin, antiplatelet, DextranPreg: BNama Dagang: Fraxiparine

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 230: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIloprostI: Hipertensi pulmonal primer atau sekunder krn penyakit jaringan ikat atau krn diinduksi obat pd stadium sedang & berat.BSO: Lar inhalasi 2ccD: Dws: 2.5-5 mcg. Jika digunakan dg HaloLite atau Prodose: dosis pd mouthpiece 2.5 mcg, waktu inhalasi 8-10 mnt. Dosis harian 6-9x/hr.Ggn hati: Awal 2.5 mcg dg interval min 3 jam (max 6x/hr)KI: Ulkus peptic aktif, perdarahan intrakranialP: ES: IO: Vasodilator & obat antihipertensi, antikoagulanPreg: CNama Dagang:Ventavis

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 231: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCilostazolI: Symptomatic management of peripheral vascular disease, primarily intermittent claudication; currently being investigated for the treatment of acute coronary syndromesBSO: Tablet: 50 mg, 100 mg

D: Adults: Oral: 100 mg 2x/d 1 ½ -2 hours ; dosage should be reduced to 50 mg 2x/d during concurrent therapy with inhibitors of CYP3A4 or CYP2C19 (see Drug Interactions)KI: Hypersensitivity, heart failure (of any severity)P: Use with caution in patients receiving platelet aggregation inhibitors, hepatic impairment. Use with caution in patients receiving inhibitors of CYP3A4 (such as ketoconazole or erythromycin) or inhibitors of CYP2C19 (such as omeprazole); use with caution in severe underlying heart disease; use is not recommended in nursing mothersES: >10%: Headache, Abnormal stools, diarrhea, Infection.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 232: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index2-10%: Peripheral edema, palpitation, tachycardia, Dizziness, Dyspepsia, nausea, abdominal pain, flatulence, Back pain, myalgia, Rhinitis, pharyngitis, cough IO: Preg: C Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 233: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFondaparinux sodiumI: Mencegah tomboembolik pd pasien bedah ortopedi tungkai bawahBSO: Jarum Suntik Prefilled 2.5 mg/0.5ccD: 2.5 mg SC 6 jam post op, lalu 2.5mg/hr selama 5-9 hariKI: Perdarahan aktifP: ES: IO: Preg:: A, B, C, D, X Nama Dagang:Arixtra

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 234: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAntithrombin IIII: Hereditary antithrombin III deficiencyBSO: Powder for injection: 500 U D: Adults: After first dose of antithrombin III, level should increase to 120% of normal; thereafter maintain at levels >80%. Generally, achieved by administration of maintenance doses once every 24 hours. Initially and until patient is stabilized, measure antithrombin III level at least twice daily, thereafter once daily and always immediately before next infusion. 1 unit = quantity of antithrombin III in 1 mL of normal pooled human plasma; administration of 1 unit/1 kg raises AT-III level by 1% to 2%; assume plasma volume of 40 mL/kg. Measure antithrombin III preceding and 30 minutes after dose to calculate in vivo recovery rate; maintain level within normal range for 2-8 days depending on type of surgery or procedure. KI: Hypersensitivity to antithrombin III or any componentP: Can potentially transmit infectious diseases since it is a product of human plasma. Discuss risk versus benefits with

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 235: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexpatient. Reduce the dose of heparin to avoid bleeding when used concurrently. Administer alone by the I.V. route only.ES: 1% to 10%: Central nervous system: Dizziness (2%) IO: Drugs which affect platelet function (eg, aspirin, NSAIDs, dipyridamole, ticlopidine, clopidogrel) may potentiate the risk of hemorrhage. Heparin's anticoagulant effects are potentiated by antithrombin III. Thrombolytic agents increase the risk of hemorrhage. Warfarin (and other oral anticoagulants) may increase the risk of bleeding with antithrombin III. Preg: C Nama Dagang: Kybernin P

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 236: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAnagrelideI: Agent for essential thrombocythemia (ET); treatment of thrombocytopenia secondary to myeloproliferative disordersBSO: Capsule: 0.5 mg, 1 mgD: Adults: Oral: 0.5 mg 4 times/day or 1 mg twice daily KI: HypersensitivityP: Patients with known or suspected heart disease, and only if the potential benefits of therapy outweigh the potential risks. Thrombocytopenia appears to be the main dose-limiting side effect of anagrelide; palpitations, orthostatic hypotension, and headache have also been reported. ES: Palpitations, chest pain, tachycardia, orthostatic hypotension, CHF, cardiomyopathy, Headache, dizziness, bad dreams, impaired concentration abilityIO: There is a single case report that suggests sucralfate may interfere with anagrelide absorptionPreg: C Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 237: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAlteplaseCommercially manufactured recombinant DNA fibrinolytic protein approved for treatment of AMI, AIS, and acute massive pulmonary embolism.BSO: Powder for injection, lyophilized (recombinant): 20 mg [11.6 million U]; 50 mg [29 million U]; 100 mg [58 million U]D:0.9 mg/kg IV; max 90 mg/dose; infuse over 60 min with 10% of total dose administered as initial IV bolus over 1 minKI:Hipersensitif; active internal bleeding; stroke within last 3 mo; recent intracranial or intraspinal surgery or trauma; intracranial hemorrhage on pretreatment evaluation; suspicion of subarachnoid hemorrhage, intracranial neoplasm, arteriovenous malformation, or aneurysm; bleeding diathesis; severe uncontrolled hypertensionIO:Drugs that alter platelet function (eg, aspirin, dipyridamole, clopidogrel, abciximab) may increase risk of bleeding prior to,

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 238: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexduring, or after alteplase therapyNote that criteria for use of IV t-PA preclude use of antiplatelet or antithrombotic agents for 24 h following t-PA infusionPreg: CP:Noncompressible arterial punctures and internal jugular and subclavian venous punctures must be avoided to minimize bleeding from noncompressible sites; in event of serious bleeding, immediately discontinue alteplase; monitor patients for allergic-type reactions, such as anaphylactoid reaction, laryngeal edema, rash, and urticaria Nama Dagang: Actilyse

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 239: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexN. Preparat Flebitis & VarisesMonoxerutinHeparinoidDiosmin Anagrelide

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 240: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMonoxerutinLihat di I. Sal Cerna > Preparat Anorektal

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 241: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexHeparinoidHeparinoid blocks the production of a chemical called prostaglandin which the body produces in response to injury or certain diseases. Prostaglandins are responsible for causing swelling, pain and inflammation, and therefore heparinoid reduces these effects. It is also able to dissolve blood clots and improve the blood supply to the skin.I: Anal itch, Inflammation of the rectum (proctitis), Piles (haemorrhoids), Tear in the lining of the back passage (anal fissure)BSO: D: KI: Children, allergic.P: ES: -IO: -Preg:: A, B, C, D, X Nama Dagang: Hirudoid

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 242: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexO. HemoreologikPentoxyfillineNaftidrofurylBuflomedilBencyclane

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 243: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPentoxyfillineI: Symptomatic management of peripheral vascular disease, mainly intermittent claudicationBSO: Tablet, controlled release: 400 mg

D: Adults: Oral: 400 mg 3x/hr ; may reduce to 400 mg 2x/d if GI or CNS side effects occurKI: Hypersensitivity; patients with recent cerebral and/or retinal hemorrhageP: Use with caution in patients with renal impairmentES: Dizziness, headache, Dyspepsia, nausea, vomiting IO: Increased effect/toxic potential with cimetidine (increased levels) and other H2-antagonists, warfarin; increased effect of antihypertensives Increased toxicity with theophylline Preg:: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 244: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNaftidrofuryl Naftidrofuryl oxalate works in two main ways. Firstly, it causes the blood vessels to widen. Secondly, it increases the ability of cells to remove waste products. Both these properties make it useful in the treatment of disorders caused by decreased blood supply to a particular area of the body.In peripheral vascular diseases, the blood vessels in the extremities are narrowed and the blood and oxygen supply to cells in the hands, feet or legs is reduced. Oxygen is required by cells in order for them to remove waste products, therefore in these conditions waste products can build up. This can cause damage to cells and lead to symptoms such as pain, cramps or ulceration. Similarly, where there is a disorder of blood flow to the brain, a lack of oxygen supply can cause damage to the cells in the brain, resulting in symptoms such as confusion or decreasing mental ability.Naftidrofuryl improves these symptoms by increasing blood and oxygen supply to the affected areas and also increasing the

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 245: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexability of the cells to remove waste products, even in low oxygen supply.I: Cerebral insufficiency, Narrowing of blood vessels in the extremities (peripheral vascular disease), cerebral atherosclerosisBSO: Tab 100 mg, 200 mg

D: 100-200 mg 3x/hrKI: Rash, Nausea, Stomach pain, hepatitisP: ES: IO: Preg:: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 246: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexP. Haematopoietic agentLenograstimFilgrastimEpoetin alfaEpoetin beta Erythropoietin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 247: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLenograstimLenograstim is a substance that stimulates the production of a type of white blood cell from the bone marrow, known as neutrophils. Neutrophils play a cental role in the body's immune system and defends the body from infections. Therefore a low level of neutrophils in the blood (neutropenia), leaves a person very susceptible to life threatening infections.Neutropenia can be caused by a number of factors, such as cancer chemotherapy and it often occurs in individuals who have recently had a bone marrow transplant or are suffering from AIDS. Lenograstim is commonly used after high dose chemotherapy regimes or bone marrow transplants, to correct low neutrophil levels in the blood and thereby reduces the duration and severity of the neutropenia. As a result, lenograstim minimises the need for antibiotic treatment, the risk of complications due to infections and length of time spent in hospital after bone marrow transplants.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 248: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexI: To increase production of stem cells (or progenitor cells), To speed up production of neutrophils following bone marrow transplants, chemotherapy induced neutropeniaBSO: Vial 33.6 MIU tau 263 mcg/ccD: Dws 150 mcg/m2/hr.1 vial dpt digunakan utk pasien dg BSA s/d 1.6 m2/hr. Transplantasi sumsum tulang (BMT): mulai 24 jam setelah transplantasi, infuse IV dlm saline 100 cc selama 30 menit.Kemoterapi sitotoksik: mulai 24 jam setelah kemoterapi lengkap inj SC, biasanya selama 8-14 hari. KI: Myeloma, Children under 2 years of ageP: Severely decreased kidney & liver functionES: Headache, Abdominal pain, Allergic reaction, Bone pain, Reactions at injection site, cutaneous vasculitis, adult respiratory distress syndrome (ARDS)Nama Dagang:Granocyte 34

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 249: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFilgrastimI: Patients with nonmyeloid malignancies receiving myelosuppressive anticancer drugs associated with a significant incidence of neutropenia (FDA-approved indication) Cancer patients receiving bone marrow transplant (BMT) (FDA-approved indication) Patients undergoing peripheral blood progenitor cell (PBPC) collection Patients with severe chronic neutropenia (SCN) (FDA-approved indication) Chronic administration in symptomatic patients with congenital neutropenia, cyclic neutropenia, or idiopathic neutropenic; filgrastim should not be started until the diagnosis of SCN is confirmed, as it may interfere with diagnostic efforts Safety and efficacy of G-CSF given simultaneously with cytotoxic chemotherapy have not been established; concurrent treatment may increase myelosuppression; G-CSF should be avoided in patients receiving concomitant chemotherapy and radiation therapy

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 250: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexBSO: Injection, preservative free: 300 mcg/mLD: Children and Adults: Existing clinical data suggest that starting G-CSF between 24 and 72 hours subsequent to chemotherapy may provide optimal neutrophil recover; continue therapy until the occurrence of an absolute neutrophil count of 10,000 L after the neutrophil nadir The available data suggest that rounding the dose to the nearest vial size may enhance patient convenience and reduce costs without clinical detrimentNeonates: 5-10 mcg/kg/day once daily for 3-5 days has been administered to neutropenic neonates with sepsis; there was a rapid and significant increase in peripheral neutrophil counts and the neutrophil storage pool Children and Adults: Myelosuppressive chemotherapy infusion: 5 mcg/kg/day IV/SCDoses may be increased in increments of 5 mcg/kg for each chemotherapy cycle, according to the duration and severity of the absolute neutrophil count (ANC) nadir

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 251: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexBone marrow transplant patients: 5-10 mcg/kg/day as an I.V. infusion of 4 or 24 hours or as continuous 24-hour S.C. infusion; administer first dose at least 24 hours after cytotoxic chemotherapy and at least 24 hours after bone marrow infusion; if ANC decreases <1000/mm3 during the 5 mcg/kg/day dose, increase filgrastim to 10 mcg/kg/day and follow the recommended steps based on neutrophil response: When ANC >1000/mm3 for 3 consecutive days: Reduce Filgrastim dose to 5 mcg/kg/day If ANC remains >1000/mm3 for 3 more consecutive days: Discontinue filgrastim If ANC decreases to <1000/mm3 : Resume at 5 mcg/kg/day If ANC decreases <1000/mm3 during the 5 mcg/kg/day dose, increase filgrastim to 10 mcg/kg/day and follow the above steps Peripheral blood progenitor cell (PBPC) collection: 10 mcg/kg/day either S.C. or a bolus or continuous I.V. infusion. It is recommended that G-CSF be given for at least 4 days before the first leukapheresis procedure and continued until the last leukapheresis; although the optimal duration of administration

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 252: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexand leukapheresis schedule have not been established, administration of G-CSF for 6-7 days with leukaphereses on days 5,6 and 7 was found to be safe and effective; neutrophil counts should be monitored after 4 days of G-CSF, and G-CSF dose-modification should be considered for those patients who develop a white blood cell count >100,000/mm3

Severe chronic neutropenia: S.C.: Congenital neutropenia: 6 mcg/kg/dose twice daily Idiopathic/cyclic neutropenia: 5 mcg/kg single dose daily Chronic daily administration is required to maintain clinical benefit; adjust dose based on the patients' clinical course as well as ANC; in phase III studies, the target ANC was 1500-10,000/mm3. Reduce the dose if the ANC is persistently >10,000/mm3

Premature discontinuation of G-CSF therapy prior to the time of recovery from the expected neutrophil is generally not recommended; a transient increase in neutrophil counts is typically seen 1-2 days after initiation of therapy Hemodialysis: Supplemental dose is not necessary

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 253: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPeritoneal dialysis: Supplemental dose is not necessary KI: Hypersensitivity to E. coli-derived proteins or G-CSFP: Complete blood count and platelet count should be obtained prior to chemotherapy. Do not use G-CSF in the period 12-24 hours before to 24 hours after administration of cytotoxic chemotherapy because of the potential sensitivity of rapidly dividing myeloid cells to cytotoxic chemotherapy. Precaution should be exercised in the usage of G-CSF in any malignancy with myeloid characteristics. G-CSF can potentially act as a growth factor for any tumor type, particularly myeloid malignancies. Tumors of nonhematopoietic origin may have surface receptors for G-CSF.ES: Neutropenic fever, fever, Alopecia, Nausea, vomiting, diarrhea, mucositis, This occurs more commonly in patients with cyclic neutropenia/congenital agranulocytosis who received S.C. injections for a prolonged (>14 days) period of time; ~33% of these patients experience subclinical splenomegaly (detected by MRI or CT scan); ~3% of these patients experience clinical splenomegaly, Medullary bone pain (24% incidence): This

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 254: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexoccurs most commonly in lower back pain, posterior iliac crest, and sternum and is controlled with non-narcotic analgesics 1-10%: Chest pain, fluid retention, Headache, Skin rash, Anorexia, stomatitis, constipation, Leukocytosis, Pain at injection site, Weakness, Dyspnea, cough, sore throat IO: Drugs which may potentiate the release of neutrophils (eg, lithium) should be used with cautionPreg: C Nama Dagang:Neupogen

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 255: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexEpoetin αI: Treatment of anemia associated with chronic renal failure, including patients on dialysis (end-stage renal disease) and patients not on dialysis Treatment of anemia related to zidovudine therapy in HIV-infected patients; in patients when the endogenous erythropoietin level is less than or equal to 500 mU/mL and the dose of zidovudine is less than or equal to 4200 mg/week Treatment of anemia in cancer patients on chemotherapy; in patients with nonmyeloid malignancies where anemia is caused by the effect of the concomitantly administered chemotherapy; to decrease the need for transfusions in patients who will be receiving chemotherapy for a minimum of 2 months Reduction of allogeneic block transfusion in surgery patients scheduled to undergo elective, noncardiac, nonvascular surgery BSO: 1 mL single-dose vials: Preservative-free solution 2000 U/mL, 3000 U/mL, 4000 U/mL, 10,000 U/mL 20,000 U/mL, 40,000 U/mL 2 mL multidose vials: Preserved solution: 10,000 U/mL

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 256: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexD: Chronic renal failure patients: I.V., S.C.: Initial dose: 50-100 U/kg 3 times/week Reduce dose by 25 U/kg when 1) hematocrit approaches 36% or2) when hematocrit increases >4 points in any 2-week period Increase dose if hematocrit does not increase by 5-6 points after 8 weeks of therapy and hematocrit is below suggested target range Suggested target hematocrit range: 30% to 36% Maintenance dose: Individualize to target range Dialysis patients: Median dose: 75 U/kg 3 times/week Nondialysis patients: Doses of 75-150 U/kg Zidovudine-treated, HIV-infected patients: Patients with erythropoietin levels >500 mU/mL are unlikely to respond Initial dose: I.V., S.C.: 100 U/kg 3 times/week for 8 weeks Increase dose by 50-100 U/kg 3 times/week if response is not satisfactory in terms of reducing transfusion requirements or increasing hematocrit after 8 weeks of therapy

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 257: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexEvaluate response every 4-8 weeks thereafter and adjust the dose accordingly by 50-100 U/kg increments 3 times/week If patients have not responded satisfactorily to a 300 unit/kg dose 3 times/week, it is unlikely that they will respond to higher doses Stop dose if hematocrit exceeds 40% and resume treatment at a 25% dose reduction when hematocrit drops to 36% Cancer patients on chemotherapy: Treatment of patients with erythropoietin levels >200 mU/mL is not recommendedInitial dose: S.C.: 150 U/kg 3 times/week Dose adjustment: If response is not satisfactory in terms of reducing transfusion requirement or increasing hematocrit after 8 weeks of therapy, the dose may be increased up to 300 U/kg 3 times/week. If patients do not respond, it is unlikely that they will respond to higher doses. If hematocrit exceeds 40%, hold the dose until it falls to 36% and reduce the dose by 25% when treatment is resumed

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 258: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSurgery patients: Prior to initiating treatment, obtain a hemoglobin to establish that is is >10 mg/dL or less than or equal to 13 mg/dL Initial dose: S.C.: 300 U/kg/day for 10 days before surgery, on the day of surgery, and for 4 days after surgery Alternative dose: S.C.: 600 U/kg in once weekly doses (21, 14, and 7 days before surgery) plus a fourth dose on the day of surgery KI: Hypersensitivity to albumin (human) or mammalian cell-derived products; uncontrolled hypertensionP: Blood pressure, platelets in your blood should be regularly monitored during the first eight weeks of treatment with this medicine.# People with kidney failure should have the levels of salts (electrolytes, eg potassium) and haemoglobin in their blood monitored during treatment with this medicine.# People with cancer should have the amount of haemoglobin in their blood monitored while receiving treatment with this medicine.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 259: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index# If you are receiving dialysis treatment, your dialysis regimen may need adjusting while receiving this medicine. Your doctor will decide this.# All other causes of anaemia, eg iron, vitamin B12 or folate deficiency, should be considered by your doctor and treated if necessary, before you start treatment with this medicine.# People receiving this medicine prior to bone surgery should also receive medication to prevent blood clots, since there is a risk of this occuring following surgery, particularly in people with cardiovascular disease.# All people who receive epoetinum alfa to stimulate blood cell production prior to bone surgery, or prior to donating blood for retransfusion during surgery, should also receive iron supplements. These should ideally be started before the epoetinum treatment, so that the body has adequate iron stores for producing new red blood cells.# Very rarely, this medicine may stop working in people with chronic kidney failure due to the body producing antibodies against the medicine. This causes the production of red blood

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 260: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexcells to stop, a condition known as pure red cell aplasia. For this reason, people with kidney failure must only receive this medicine by injection into a vein (IVly). In the very rare case that pure red cell aplasia develops, this medicine should be stopped and patients should not be switched to any other erythropoietin.# Tell your doctor if you experience sudden stabbing migraine-like headaches while receiving this medicine, as this may be a possible warning sign that your blood pressure is too high.ES: Skin rashes, Cold or flu-like symptoms, hypertensive crisis), thrombosis, thrombocytosisIO: Preg: CNama Dagang: Hemapo

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 261: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexEpoetin betaSynthetic version of the naturally-occurring hormone erythropoietin. Erythropoietin is produced by healthy kidneys. It stimulates the bone marrow to produce red blood cells, which carry oxygen around the body. Epoetin beta is used to treat anaemia in people with chronic kidney failure who are undergoing dialysis, and in people with impaired kidney function who do not yet need dialysis. These people produce very little erythropoietin as a result of their kidney disease, so the number of red blood cells in their blood is low (anaemia). When epoetin beta is injected, it stimulates the bone marrow to produce more red blood cells, and this corrects the anaemia. Epoetin beta is also used to treat anaemia in people with certain types of cancer. It is used to treat anaemia in adults with solid tumours who are receiving platinum-based chemotherapy. It is also used to treat anaemia in people with non-Hodgkins lymphoma, bone marrow cancer (multiple myeloma) or chronic lymphocytic leukaemia who are receiving anti-tumour therapy.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 262: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexThe increased red blood cell production stimulated by epoetin beta reduces the chances of these people needing a blood transfusion.Premature babies born at less than 34 weeks gestation may also be given epoetin beta to stimulate the production of red blood cells and prevent the development of anaemia.Doctors may also prescribe epoetin beta for anaemic people who are going to donate blood prior to surgery so that their own blood can be given to them during or after surgery. This is called an autologous blood pre-donation programme. Because the epoetin increases blood cell production, it means that a larger volume of blood can be taken from these people, and stored for transfusion during or after the surgery. Your doctor may also prescribe you iron supplements while you are receiving this medicine so that the body has adequate iron stores for producing new red blood cells.I: # Treating anaemia due to kidney disease# Treating anaemia in people with solid tumours being treated with platinum-based chemotherapy

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 263: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index# Treating anaemia in people with bone marrow cancer (multiple myeloma), low-grade non-Hodgkins lymphoma or chronic lymphocytic leukaemia who are receiving chemotherapy# Preventing anaemia in premature babies of less than 34 weeks gestation with a birth weight of 750-1500g# Increasing the volume of blood that can be donated by anaemic patients due to have surgery, so they can receive transfusions of their own blood during or after the surgeryBSO: Jarum suntik pre-filled 2.000 iu, 10.000 iuD: Anemia dg gagal ginjal:Fase koreksi: SC: awal 3 x 20 IU/kg/minggu, titrasi tiap 4 minggu.IV: awal 3 x 40 IU/kg/minggu, titrasi tiap 4 mgg 3 x 80 IU/kg/mggSelanjutnya ditingkatkan 20 iu/kg 3x/mgg, interval per bulan. Max 720 IU/kgBB.Fase pemeliharaan:Awal dikurangi ½ dari pemberian terakhirAnemia pd premature:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 264: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index3x 250 iu/kg/mgg SC, mulai hari ke-3 kehidupan. Lama 6 minggu.KI: hypertension, pure red cell aplasia, deep vein thrombosis, heart attack or stroke in the last month, unstable anginaP: kidney disease, hypertension, thrombocytosis, Malignant disease, Chronic liver failure, Epilepsy, hyperkalaemia, phenylketonuriaES: Headache, Rise in blood pressure, Cold or flu-like symptoms, Reactions at injection site, Skin reactions such as rash and itch, Increased numbers of platelets in the blood, thrombosis, hypertensive crisisIO: Preg: Nama Dagang:Recormon

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 265: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexErythropoietinI: D: Dosis KI: P: ES: IO: Preg:: A, B, C, D, X BSO: Nama Dagang:Eprex

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 266: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexQ. Anti HipotensiEphedrine HCl

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 267: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexEphedrine HCl-- Stimulates release of epinephrine stores, producing alpha- and beta-adrenergic receptors. D: 5-10 mg PO/IM q6h. 25-mg supp PR q12h Paed.: 2-5 years: 3 mg PO q6-8h>5 years: 6.25 mg PO q6-8hKI: Hipersensitif; angle-closure glaucoma; cardiac arrhythmias IO: Theophylline, atropine, or MAOIs may increase toxicity; alpha- and beta-blockers decrease vasopressor effects of ephedrine; cardiac glycosides and general anesthetics increase cardiac stimulation of ephedrine Preg: BP: Adverse effects (eg, excitation, tremulousness, insomnia, nervousness, palpitation, tachycardia, other symptoms associated with sympathetic activation); bladder sphincter spasm (may cause a transient acute urinary retention); caution in elderly and in patients with DM, hyperthyroidism, hypertension, cardiovascular disease, prostatic hypertrophy, or cerebrovascular insufficiency

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 268: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexR.Obat Kardiovaskuler LainAdenosineHeptaminol HCl

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 269: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAdenosineAdenosine is an anti-arrhythmic medicine which acts by slowing the conduction of electrical impulses across the atrioventricular node in the heart. Adenosine is a natural body chemical.In the normal situation electrical impulses start in the sinus node in the heart and spread over the atria (upper chambers of the heart), casuing them to contract. The impulse then passes through the atrio-ventricular node (AV-node) to the ventricles (lower chambers of the heart). The impulse spreads over the ventricles, causing them to contract and pump blood out to the rest of the body. Adenosine is used to treat paroxysmal supraventricular tachycardias, that is, fast, irregular rhythms starting with impulses above the AV node. It quickly causes the heart to return to its normal rhythm.Adenosine is given as a rapid IV bolus.BSO: Diagnostic use: 60 mg/20 mL and 90 mg/30 mL single-dose vials Injection, preservative free: 3 mg/mL

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 270: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexI: Abnormal heart rhythms caused by abnormal contractions in the upper part of the heart (supraventricular arrhythmias)D: Rapid I.V. push (over 1-2 seconds) via peripheral line:Neonates: Initial dose: 0.05 mg/kg; if not effective within 2 minutes, increase dose by 0.05 mg/kg increments every 2 minutes to a maximum dose of 0.25 mg/kg or until termination of PSVT Maximum single dose: 12 mg Infants and Children: Pediatric advanced life support (PALS): Treatment of SVT: 0.1 mg/kg; if not effective, administer 0.2 mg/kg Alternatively: Initial dose: 0.05 mg/kg; if not effective within 2 minutes, increase dose by 0.05 mg/kg increments every 2 minutes to a maximum dose of 0.25 mg/kg or until termination of PSVT; medium dose required: 0.15 mg/kg Maximum single dose: 12 mg Adults: 6 mg; if not effective within 1-2 minutes, 12 mg may be given; may repeat 12 mg bolus if needed Maximum single dose: 12 mg

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 271: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFollow each I.V. bolus of adenosine with normal saline flush Note: Preliminary results in adults suggest adenosine may be administered via a central line at lower doses (ie, initial adult dose: 3 mg). Continuous I.V. infusion via peripheral line: 140 mcg/kg/minute for 6 minutes using syringe or columetric infusion pump; total dose: 0.84 mg/kg. Thallium-201 is injected at midpoint (3 minutes) of infusion. Hemodialysis: Significant drug removal is unlikely based on physiochemical characteristics. Peritoneal dialysis: Significant drug removal is unlikely based on physiochemical characteristics. Note: Patients who are receiving concomitant theophylline therapy may be less likely to respond to adenosine therapy. Note: Higher doses may be needed for administration via peripheral versus central vein. KI: Hypersensitivity, second- or third-degree A-V block or sick sinus syndrome (except in patients with a functioning artificial pacemaker), atrial flutter, atrial fibrillation, and ventricular

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 272: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indextachycardia (this drug is not effective in converting these arrhythmias to sinus rhythm). The manufacturer states that Adenoscan® should be avoided in patients with known or suspected bronchoconstrictive or bronchospastic lung disease.P: Patients with pre-existing S-A nodal dysfunction may experience prolonged sinus pauses after adenosine. There have been reports of atrial fibrillation/flutter in patients with PSVT associated with accessory conduction pathways after adenosine. Adenosine decreases conduction through the A-V node and may produce a short-lasting first-, second-, or third-degree heart block. Because of the very short half-life, the effects are generally self-limiting. Rare, prolonged episodes of asystole have been reported, with fatal outcomes in some cases. At the time of conversion to normal sinus rhythm, a variety of new rhythms may appear on the EKG. A limited number of patients with asthma have received adenosine and have not experienced exacerbation of their asthma. Adenosine may cause bronchoconstriction in patients with asthma, and should be used cautiously in patients with obstructive lung

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 273: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexdisease not associated with bronchoconstriction (eg, emphysema, bronchitis).ES: >10%: Facial flushing, palpitations, chest pain, hypotension Headache, Shortness of breath/dyspnea, Sweating 1% to 10%: Dizziness, Nausea (3%), Paresthesia, numbness , Chest pressure (7%) IO: Theophylline and caffeine (methylxanthines) antagonize adenosine's effects; may require increased dose of adenosine. Dipyridamole potentiates effects of adenosine; reduce dose of adenosine. Carbamazepine may increase heart blockPreg: C Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 274: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexHeptaminol HClI: Astenia & kelelahan. Hipotensi & defisiensi KV.BSO: Tab 150 mg. amp 250 mg/5ccD: Astenia, Hipotensi & PsikiatriDws: 300 mg 2x/hari.Anak: 20 mg/kg/hari terbagi dlm 3 dosisResusitasi dewasa: 2 amp IV sekaligus/IMNeonatus 2 cc ke dalam tali pusatKI: Hipertensi, tiroid P: ES: IO: Preg: A, B, C, D, X*Nama Dagang: Hep-A-Myl

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 275: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIII. SALURAN NAFASA. ANTI ASTHMA & PPOKB. COUGH & COLD REMEDIAC. DEKONGESTAN & PREPARAT NASAL LAIND. OBAT PERNAPASAN LAIN

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 276: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexA. Anti Asthma & PPOKSalbutamol/ AlbuterolTheophylline/ AminophyllineOrciprenaline sulphate/ MetaproterenolIpratopium bromideTiotropium bromideAcefylline piperazine Ephedrine HClTerbutalineBudesonide Isoproterenol Fenoterol ClenbuterolKetotifen ZafirlukastFluticasone SalmeterolProcaterol BeclomethasoneTrimetoquinol HCl

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 277: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSalbutamol/ Albuterol-- Beta-agonist for bronchospasm refractory to epinephrine. Relaxes bronchial smooth muscle by action on beta-2 receptors, with little effect on cardiac muscle contractility. Most patients (even those with no measurable increase in expiratory flow) benefit from treatment. Inhaled beta-agonists initially are prescribed prn. Frequency may be increased; institute regular schedule in patients on anticholinergic drugs who are still symptomatic.Available as a liquid for nebulizer, metered-dose inhalers (MDI), and dry-powder inhalers.D: MDI: 2 puffs q3-4hNebulizer: 0.2-0.3 mL of 5% solution diluted to 2.5 mL with NS tid/qidNebulizerInfants and children: 0.01-0.02 mL of 5% solution diluted in 2-3 mL NS q4-6hAdolescents: Administer as in adults

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 278: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexKI: Hipersensitif; preexisting cardiac arrhythmia associated with tachycardiaIO:Beta-adrenergic blockers antagonize effects; inhaled ipratropium may increase duration of bronchodilatation; cardiovascular effects may increase with MAOIs, inhaled anesthetics, TCAs, and sympathomimetic agentsPreg: CP:Adverse effects include muscle tremor, nervousness, insomnia, transient hypoxemia, and tachycardia; caution in hyperthyroidism, DM, hypertension, ischemic heart disease, seizures, and pheochromocytoma Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 279: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTheophylline/ Aminophylline -- Mechanism of action is not well defined yet. Was formerly thought that this drug increases intracellular cyclic AMP by causing inhibition of phosphodiesterase; however, current data do not support that.D: 1st 5-8 mg/kg/d, then in the range of 5-15 mcg/mL; 5.6 mg/kg loading dose (based on aminophylline) IV over 20 min, followed by maintenance infusion of 0.1-1.1 mg/kg/hPaed.6 weeks to 6 months: 0.5 mg/kg/h loading dose IV in first 12 h (based on aminophylline), followed by maintenance infusion of 12 mg/kg/d thereafter; may administer continuous infusion by dividing total daily dose by 24 h6 months to 1 year: 0.6-0.7 mg/kg/h loading dose IV in first 12 h, followed by maintenance infusion of 15 mg/kg/d; may administer as continuous infusion, as aboveKI: Hipersensitif; uncontrolled arrhythmias; peptic ulcers; hyperthyroidism; uncontrolled seizure disorders

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 280: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIO: Effects may decrease with aminoglutethimide, barbiturates, carbamazepine, ketoconazole, loop diuretics, charcoal, hydantoins, phenobarbital, phenytoin, rifampin, isoniazid, and sympathomimetics; effects may increase with allopurinol, beta-blockers, ciprofloxacin, corticosteroids, disulfiram, quinolones, thyroid hormones, ephedrine, carbamazepine, cimetidine, erythromycin, macrolides, propranolol, and interferonPreg: CP: Has low serum therapeutic-to-toxicity ratio, and, therefore, serum level monitoring is important; peptic ulcer; hypertension; tachyarrhythmias; hyperthyroidism; compromised cardiac function; do not inject IV solution faster than 25 mg/min; patients diagnosed with pulmonary edema or liver dysfunction are at greater risk of toxicity because of reduced drug clearanceNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 281: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexOrciprenaline/ Metaproterenol-- Relaxes bronchial smooth muscle by action on beta-2 receptors, with little effect on cardiac muscle contractility. Most patients (even those with no measurable increase in expiratory flow) benefit from treatment. Inhaled beta-agonists initially are prescribed prn. Frequency may be increased; institute regular schedule in patients on anticholinergic drugs who are still symptomatic.D: MDI: 2 puffs q3-4hNebulizer: 0.2-0.3 mL of 5% sol. diluted to 2.5 mL+ NS tid/qidNebulizer Infants and children: 0.01-0.02 mL of 5% solution diluted in 2-3 mL of NS q4-6hKI:Hipersensitif; arrhythmia associated with tachycardiaIO:Beta-adrenergic blockers antagonize effects; inhaled ipratropium may increase duration of bronchodilatation;

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 282: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexcardiovascular effects may increase with MAOIs, inhaled anesthetics, TCAs, and sympathomimetic agentsPreg: CP:Caution in hypertension, cardiovascular disease, congestive heart failure, hyperthyroidism, diabetes, and seizures; not recommended during breastfeeding; adverse reactions include tachycardia, headache, nervousness, dizziness, tremor, GI upset, hypertension, paradoxical bronchospasm, and cough Nama Dagang:Alupent

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 283: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIpratopiumD: MDI: 2-4 puffs q4-6hNebulizer: 250 mcg diluted with 2.5 mL NS q4-6hPaed.MDI: 1-2 puffs tid; max 6 puffs per dNebulizer: 250 mcg tidKI: Hipersensitif IO:Drugs with anticholinergic properties (eg, dronabinol) may increase toxicity; albuterol may increase effectsPreg: CP:Caution in narrow-angle glaucoma, prostatic hypertrophy, or bladder neck obstruction Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 284: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTiotropium-- A quaternary ammonium compound. Elicits anticholinergic/antimuscarinic effects with inhibitory effects on M3 receptors on airway smooth muscles, leading to bronchodilation. Available as a capsule dosage form containing a dry powder for oral inhalation via the HandiHaler inhalation device. Helps patients with COPD by dilating narrowed airways and keeping them open for 24 h.D: Inhale contents of 1 cap (18 mcg) via HandiHaler device qdMDI1-2 puffs tid; max 6 puffs/dKI: HipersensitifIO: Coadministration with other anticholinergic containing drugs (eg, ipratropium) may increase toxicity riskPreg: CP: For maintenance treatment only; not effective for acute (rescue) therapy of bronchospasm; discontinue use and consider other treatments if immediate hypersensitivity reactions (including angioedema) or paradoxical bronchospasm

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 285: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexoccur; caution with narrow-angle glaucoma, prostatic hyperplasia, or bladder neck obstruction; commonly causes dry mouth; may cause constipation, increased heart rate, blurred vision, glaucoma, and urinary difficulty or retention; monitor patients with moderate-to-severe renal impairment Nama Dagang: Spiriva

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 286: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAcefylline piperazineI: Asma bronchial, spasme bronkus pd bronchitis, ggn nafas/ sesak scr umum, sesak krn insufisiensi jantung, emfisema & ggn obstruksi Pulmoner kronis.BSO: Tab salut selaput 250 mg. amp 500 mg/5ccD: Tab 2-8 tab/hr dlm dosis terbagi. Amp IM 3-4 amp/hr. IV 1-2 amp/hrKI: P: ES: IO: Preg:: A, B, C, D, X Nama Dagang: Etaphylline

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 287: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexEphedrine HClI: Treatment of bronchial asthma, nasal congestion, acute bronchospasm, idiopathic orthostatic hypotensionvBSO: Capsule: 25 mg, 50 mg Injection: 25 mg/mL; 50 mg/mL Jelly: 1% Spray: 0.25%D: Children: Oral, S.C.: 3 mg/kg/day or 25-100 mg/m2/day in 4-6 divided doses every 4-6 hours I.M., slow I.V. push: 0.2-0.3 mg/kg/dose every 4-6 hours Adults: Oral: 25-50 mg every 3-4 hours as needed I.M., S.C.: 25-50 mg, parenteral adult dose should not exceed 150 mg in 24 hours I.V.: 5-25 mg/dose slow I.V. push repeated after 5-10 minutes as needed, then every 3-4 hours max 150 mg/24 hours

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 288: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexKI: Hypersensitivity to ephedrine or any component, cardiac arrhythmias, angle-closure glaucoma, patients on other sympathomimetic agentsP: Blood volume depletion should be corrected before ephedrine therapy is instituted; use caution in patients with unstable vasomotor symptoms, diabetes, hyperthyroidism, prostatic hypertrophy, or a history of seizures; also use caution in the elderly and those patients with cardiovascular disorders such as coronary artery disease, arrhythmias, and hypertension. Ephedrine may cause hypertension resulting in intracranial hemorrhage. Long-term use may cause anxiety and symptoms of paranoid schizophrenia. Avoid as a bronchodilator; generally not used as a bronchodilator since new beta2 agents are less toxic. Use with caution in the elderly, since it crosses the blood-brain barrier and may cause confusion.ES: >10%: Central nervous system: CNS stimulating effects, nervousness, anxiety, apprehension, fear, tension, agitation, excitation, restlessness, irritability, insomnia, hyperactivity

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 289: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index1% to 10%: Cardiovascular: Hypertension, tachycardia, palpitations, elevation or depression of blood pressure, unusual pallor Central nervous system: Dizziness, headache Gastrointestinal: Xerostomia, nausea, anorexia, GI upset, vomiting Genitourinary: Painful urination Neuromuscular & skeletal: Trembling, tremor (more common in the elderly), weakness Miscellaneous: Diaphoresis (increased) IO: Decreased effect: Alpha- and beta-adrenergic blocking agents decrease ephedrine vasopressor effects Increased toxicity: Additive cardiostimulation with other sympathomimetic agents; theophylline cardiostimulation; MAO inhibitors or atropine may increase blood pressure; cardiac glycosides or general anesthetics may increase cardiac stimulation Preg: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 290: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTerbutaline I: Asthma, Chronic obstructive pulmonary disease (COPD)BSO: Aerosol, oral: 0.2 mg/actuation Injection: 1 mg/mL Tablet: 2.5 mg, 5 mg D: Children <12 years: Oral: Initial: 0.05 mg/kg/dose 3x/day, increased; max: 0.15 mg/kg/dose 3-4x/day or a total of 5 mg/24 hours S.C.: 0.005-0.01 mg/kg/dose to a max of 0.3 mg/dose every 15-20 minutes for 3 doses Nebulization: 0.01-0.03 mg/kg/dose q4-6 hours Inhalation: 1-2 inhalations q4-6 hours Children >12 years and Adults: Oral: 12-15 years: 2.5 mg q6h 3 x/day; max 7.5 mg/day >15 years: 5 mg/dose every 6 hours 3 times/day; if side effects occur, reduce dose to 2.5 mg every 6 hours; max 15 mg in 24 hours

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 291: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexS.C.: 0.25 mg/dose repeated in 15-30 minutes for one time only; a total dose of 0.5 mg should not be exceeded within a 4-hour period Nebulization: 0.01-0.03 mg/kg/dose every 4-6 hours Inhalation: 2 inhalations every 4-6 hours; wait 1 minute between inhalations Dosing adjustment/comments in renal impairment:Clcr 10-50 mL/minute: Administer at 50% of normal dose Clcr <10 mL/minute: Avoid use KI: Allergy P: Diabetes, Heart disease, hypertension, ThyrotoxicosisES: Tremor, Headache, Nausea, heart palpitations, Muscle cramps, Tense feeling, Sleep disturbances, tachycardia, hypokalaemia, Mouth or throat irritation & paradoxical bronchospasm (with inhaler devices)IO: Decreased effect with beta-blockers Increased toxicity with MAO inhibitors, TCAs Preg:: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 292: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexBudesonideInhibits bronchoconstriction mechanisms, produces direct smooth muscle relaxation, and may decrease number and activity of inflammatory cells, which, in turn, decreases airway hyperresponsiveness.BSO: Cyclocaps 200 mcgD: 200-400 mcg via PO inhalation 2x initially; increase to 800 mcg bidPaed. 200 mcg via PO inhalation 2x initially; may increase to 400 mcg bidKI: Hipersensitif; bronchospasm, status asthmaticus, and other types of acute episodes of asthmaIO: Coadministration with ketoconazole may increase plasma levels but does not appear to be clinically significantPreg: B, C.P: Coughing, upper respiratory tract infection, and bronchitis may occur Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 293: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIsoproterenolI: Treatment of reversible airway obstruction as in asthma or COPD; used parenterally in ventricular arrhythmias due to A-V nodal block; hemodynamically compromised bradyarrhythmias or atropine-resistant bradyarrhythmias; temporary use in third degree A-V block until pacemaker insertion; low cardiac output; vasoconstrictive shock statesBSO: Inhalation: Aerosol: 0.2% (1:500); 0.25% (1:400) Solution for nebulization: 0.031%; 0.062%; 0.25% ; 0.5%; 1% Injection: 0.2 mg/mL (1:5000) Tablet, sublingual: 10 mg, 15 mg D: Children: Bronchodilation: Inhalation: Metered dose inhaler: 1-2 dose up to 5 times/day Bronchodilation (using 1:200 inhalation solution) 0.01 mL/kg/dose every 4 hours as needed (max: 0.05 mL/dose) diluted with NS to 2 mL Sublingual: 5-10 mg every 3-4 hours, max 30 mg/day

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 294: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCardiac arrhythmias: I.V.: Start 0.1 mcg/kg/minute (usual effective dose 0.2-2 mcg/kg/minute) Adults: Bronchodilation: Inhalation: Metered dose inhaler: 1-2 metered doses 4-6 times/day Bronchodilation: 1-2 inhalations of a 0.25% solution, no more than 2 inhalations at any one time (1-5 minutes between inhalations); no more than 6 inhalations in any hour during a 24-hour period; maintenance therapy: 1-2 inhalations 4-6 times/day. Alternatively: 0.5% solution via hand bulb nebulizer is 5-15 deep inhalations repeated once in 5-10 minutes if necessary; treatments may be repeated up to 5 times/day. Sublingual: 10-20 mg every 3-4 hours; max 60 mg/day Cardiac arrhythmias: I.V.: 5 mcg/minute initially, titrate to patient response (2-20 mcg/minute) Shock: I.V.: 0.5-5 mcg/minute; adjust according to response KI: Angina, pre-existing cardiac arrhythmias (ventricular); tachycardia or A-V block caused by cardiac glycoside

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 295: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexintoxication; allergy to sulfites or isoproterenol or other sympathomimetic aminesP: Elderly patients, diabetics, renal or cardiovascular disease, hyperthyroidism; excessive or prolonged use may result in decreased effectivenessES: >10%: Insomnia, restlessness, Dry throat, xerostomia, discoloration of saliva (pinkish-red) 1% to 10%: Flushing of the face or skin, ventricular arrhythmias, tachycardias, profound hypotension, hypertension, Nervousness, anxiety, dizziness, headache, lightheadedness, Vomiting, nausea, Trembling, tremor, weakness, Diaphoresis IO: Increased toxicity: Sympathomimetic agents may cause headaches and elevate blood pressure; general anesthetics may cause arrhythmiasPreg: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 296: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFenoterol HBrI: AsmaBSO: Inhaler dosis terukur 100 mcg/semprot. 200 mcg/semprot. Larutan inhalasi 0.1%D: Asma akut: 1 semprot. Maks 8 semprot/hrLar inhalasi, tunggal: 0.2-1 mg 3x/hr dg interval min 3 jam KI: Kardiomiopati obstruksi hipertrofi, takiaritmiaP: ES: IO: Preg: BNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 297: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexClenbuterol HClI: PPOK (asma bronchial, bronchitis kronik & emsifema paru)BSO: Tab 10 mcg. 20 mcg. Sir 5 mcg/5ccD: Tab Dws & >12thn 40 mcg/hr. kasus berat bs 80mcg/hr. pemeliharaan 20 mcg/hr.Anak 1.2 mcg/kg/hr. Sir: 6-12thn 2x 3sdt.4-6thn 2x 2 sdt.2-4 thn 3x 1sdt.<2thn 2x 1 sdtKI: Tirotoksikosis, stenosis aorta subvalvular hipertrofik idiopatik, takikardi & takiaritmia.P: IMA, DM, hipertensiES: Tremor, gelisah,ekstra systole, takikardiaIO: β-blocker, efek antagonisPreg:Nama Dagang:Spiropent

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 298: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexKetotifenKetotifen prevents the release of histamine from mast cells and also blocks H1 receptorsI: Allergic rhinitis (hayfever) or allergic conjunctivitisBSO: Tab 1 mg. Syr 1 mg/5cc

D: For asthma: 1 mg 2x/day. Anak: 50 mcg/kg 2x.KI: Pregnancy, Breastfeeding, children < 3 years of age.P: History of epilepsyES: Drowsiness, Dry mouth, Dizziness, Weight gain, Irritability, insomnia, Nervousness, Excitation, Bladder inflammation, cystitis, hepatitis, Convulsions, Isolated severe skin reactionsIO: increased risk of drowsiness: alcohol, other sedating antihistamines, tricyclic antidepressants, MAOI antidepressants, antipsychotics, opioid painkillers, benzodiazepines, barbiturates, sleeping tablets.Preg:: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 299: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexZafirlukastSelective and competitive receptor antagonist of leukotriene D4 and E4, components of slow-reacting substance of anaphylaxis. Indicated for treatment of stable, mild, persistent asthma or prophylaxis for EIA.BSO: Tab 20 mgD: 20 mg PO bid; must be taken 30 min prior to breakfast and supperKI: HipersensitifIO: Increases half-life of warfarin; erythromycin and theophylline decrease serum levelsPreg: BP: Elevations of liver enzymes occur rarely, but routine LFT monitoring not required; systemic eosinophilia and vasculitis consistent with Churg-Strauss syndrome also rarely reported; not indicated for treatment of acute asthma exacerbations Nama Dagang: Accolate

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 300: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFluticasoneTopikal Potensi Ringan Alters level of inflammation in airways by inhibiting multiple types of inflammatory cells and decreasing production of cytokines and other mediators involved in the asthmatic response.I: Topikal: prurigo nodularis, lichen simplex, Eczema, contact dermatitis, seborrhoeic dermatitis, Discoid lupus erythematosus (DLE), Inflammatory skin disorders, Intense and widespread reddening of the skin (generalised erythroderma) in combination with oral or injected corticosteroids, Prickly heat, Psoriasis, Reactions to insect bites& stings, lichen planus, neurodermatitisBSO: Nebule 0.5 mg/2cc. Krim 0.05%D: 44-mcg MDI: 2 puffs bid for mild persistent asthma110- to 220-mcg MDI: 2 puffs bid for moderate-to-severe persistent asthmaKrim: 1X/hrPaed.44-mcg MDI: 2 puffs bid

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 301: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexKI: Hipersensitif; viral, fungal, and bacterial skin infectionsTopikal: Acne vulgaris, Broken skin or open wounds, Children less than 1 year of age, acne rosacea, perioral dermatitis, Itching around the back passage and genitals, psoriasisES: Thinning of the skin, Changes in skin pigmentation, Skin irritation, Stretch marks (striae), telangiectasia, hypertrichosisIO: -Preg: CP:Not indicated to treat acute asthma exacerbation or status asthmaticus; prolonged use may increase systemic absorption and may cause Cushing syndrome, reversible HPA-axis suppression, hyperglycemia, and glycosuria; localized infections of the pharynx due to Candida albicans (5%) may occur; rare manifestation of systemic eosinophilic conditions consistent with Churg-Strauss syndrome reported Nama Dagang:Cutivate krim

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 302: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSalmeterolCan relieve bronchospasm by relaxing smooth muscles of the bronchioles in conditions associated with bronchitis, emphysema, asthma, or bronchiectasis. BSO: Inhaler 25 mcg/aktuasiRotadisk 50 mcgDiskhaler 1D: 1 inhalation (50 mcg) bid approximately 12 h apartKI: Hipersensitif; angina, tachycardia, and cardiac arrhythmias associated with tachycardiaIO: Concomitant use of beta-blockers may decrease bronchodilating and vasodilating effects of beta-agonists; concurrent administration with methyldopa may increase pressor response; coadministration with oxytocic drugs may result in severe hypotension; ECG changes and hypokalemia resulting from diuretics may worsen when coadministeredPreg: CP:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 303: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAsthma treatment:[US Boxed Warning] Long-acting beta2-agonists may increase the risk of asthma-related deaths. In a large, randomized clinical trial, salmeterol was associated with a small, but statistically significant increase in asthma-related deaths (when added to usual asthma therapy); risk may be greater in African-American patients versus Caucasians. Should only be used as adjuvant therapy in patients not adequately controlled on inhaled corticosteroids or whose disease requires two maintenance therapies; salmeterol is not meant to relieve acute asthmatic symptoms, should not be initiated in patients with significantly worsening or acutely deteriorating asthma, and is not a substitute for inhaled or oral corticosteroids; short-acting beta2-agonist should be used for acute symptoms and symptoms occurring between treatments; corticosteroids should not be stopped or reduced when salmeterol initiated; during initiation of salmeterol watch for signs of worsening asthma Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 304: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexProcaterolI: Asma, emfisema BSO: Tab 25 mcg, 50 mcg. Syr 5mcg/cc. Inhaler 10 mcg/semprot.D: Dws 2x 1 tab. < 6 thn 1-1.25 mcg/kg diberikan 2x/hrKI: P: ES: Palpitasi, demam, kemerahan, tremor IO: Preg:Nama Dagang:Meptin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 305: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexBeclomethasoneAlters level of inflammation in airways by inhibiting multiple types of inflammatory cells and decreasing production of cytokines and other mediators involved in the asthmatic response.I: BSO: Inhaler 50 mcg/semprot, 100 mcg/smprot, 200 mcg/dosisRotacap 100 mcgRotahaler 1Rotadisk 100 mcg, 200 mcgDiskhaler 1 Topikal : krim 0.025%D:2 puffs (84 mcg) tid/qid; alternatively, 4 puffs (168 mcg) bidSevere asthma: 12-16 puffs (504-672 mcg)/d; adjust dose downward to response; max 20 puffs (840 mcg)/dQVAR: 80 and 160 mcg/puffPaed.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 306: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index<6 years: Not established6-12 years: 1-2 puffs (42-84 mcg) tid/qid to response; alternatively, 4 puffs (168 mcg) bid; max 10 puffs (420 mcg)/dKI: Hipersensitif; bronchospasm, status asthmaticus, and other types of acute episodes of asthmaIO: Coadministration with ketoconazole may increase plasma levels but does not appear to be clinically significantPreg: CP: Symptoms of adrenal insufficiency due to suppression of the HPA axis may occur when being withdrawn from systemically active corticosteroids; small number of patients may develop hypercortisolism and adrenal suppression (weight gain, increased bruising, cushingoid features, acneiform lesions, mental disturbances, and cataracts may occur); localized infections of the pharynx due to C albicans (5%) reported Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 307: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTrimetoquinol HClI: AsmaBSO: Tab 3 mg. Tetes Paed 1 mg/cc. Amp 0.1 mg/ccD: Tab 1-4 tab/hr terbagi dlm 2-3x.< 6th 0.1 mg/kg/dosis 3-4x/hrTetes Paed: 3-4 thn 4-6 cc terbagi dlm 3-4 dosis 1-2 thn 2-4 cc terbagi dlm 3-4 dosis< 1 thn 1-2 cc terbagi dlm 3-4 dosisInj1-2 amp SC/IM atau ½-1 amp IV dlm Glukosa 5% atau 20% inj > 3 mnt atauInfuse 1 amp dlm 500cc D5%/ Glukosa-RingerKI: P: ES: Palpitasi, tremor, pusingIO: Katekolamin menyebabkan aritmiaPreg: Nama Dagang: Inolin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 308: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexHeptaminol acefyllinateI: Asma. BSO: Tab 500 mg. tetes 40%. Amp 500 mg/5ccD: Dws Tts 75-150 tts/hari. Tab 1.5-3 g/hari terbagi dlm 3 dosis.Amp 1-2 amp/hr IM/IV.Tetes Bayi 3 thn 2-3tts/kg/hr.Anak 3-7 thn 2-3 tts/kg/hr max 60 tetes.Anak 7-15 tahun 75-100 tetes/hari terbagi dalam 3 dosis. Lama terapi 1-3 minggu KI: P: ES: IO: Preg: Nama Dagang:Cariamyl

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 309: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexB. Cough & Cold RemediaAcetylcysteinePhenylpropanolamine HClGuaifenesin/ Glyceryl Guaiacolate & DextromethorphanTerbutalineAmbroxol HClBromhexine HClCodeine HClDextromethorphanPseudoephedrinePhenylephrineNoscapineDiphenhydramineCarbocisteineErdosteineLevodropropizineIsoaminileTipepidine hibenzate

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 310: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexN-acetylcysteine-- Inhalations may be tried to encourage sputum expectoration in patients with tenacious sputum and mucous plugging.BSO: Tab eff 600 mg. Kaps 200 mg. Sachet 200 mg. Sachet paed. Sir kering D:5-10 mg dissolved in 3 mL NSKI:HipersensitifIO:None reportedPreg: BP:Inhalations may exacerbate bronchospasm; GI distress may occurNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 311: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPhenylpropanolamine HClI: Anorexiant; nasal decongestantBSO: Capsule: 37.5 mg Tablet & Capsule timed release: 25 mg, 75 mg Tablet Precision release & Timed release: 75 mg D: 2-6 years: 6.25 mg q4h 6-12 years: 12.5 mg q4h max 75 mg/day Decongestant: 25 mg q4h or 50 mg q8h, max 150 mg/day Anorexic: 25 mg 3x/day 30 minutes a.c or 75 mg (timed release) 1x in the morning

Precision release: 75 mg after breakfast KI: hypersensitivityP: High blood pressure, tachyarrhythmias, pheochromocytoma, bradycardia, cardiac disease, arteriosclerosis; do not use for more than 3 weeks for weight lossES: >10%: Hypertension, palpitations 1-10%: Insomnia, restlessness, dizziness, Xerostomia, nausea IO: Decreased effect of antihypertensives

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 312: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIncreased effect/toxicity with MAO inhibitors (hypertensive crisis), beta-blockers (increased pressor effects) Preg: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 313: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexGuaifenesin/ Glyceryl Guaiacolate & DextromethorphanTreats minor cough resulting from bronchial and throat irritation.BSO: Caplet, sustained release 300 mg, 600 mg Capsule: 200 mg Liquid: 100 mg/5 mL, 200 mg/5 mL Tablet: 100 mg, 200 mg, 1200 mg Sustained release: 600 mg D: 5 mL PO q4h or 10 mL PO q6-8h; max 40 mL/24hPaed.1-2 mg/kg/d PO divided tid/qidKI: HipersensitifIO: -Preg: CP: Do not use to treat productive cough or persistent chronic cough resulting from emphysema Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 314: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAmbroxol HClI: Penyakit sal nafas akut & kronik yg berhubungan dg sekresi abnormal bronkus.BSO: Tab 30 mg, Syr 15 mg/5cc

D: D:1 tab 3x/hr atau 10 cc 3x/hrAnak 5-12 th: ½ tab 3x/hr atau 5 cc 3x/hrAnak 2-5 th: 2.5 cc 3x/hr<2th: 2.5cc 2x/hr

KI: HipersensitifP: HamilES: Ggn sal cerna. Jarang reaksi alergiIO: Dpt dipakai bersama kortikosteroid, bronkospasmolitik & antibiotikPreg:Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 315: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexBromhexine HClI: MukolitikBSO: Tab 8 mgSir & Elixir 4mg/5ccLar 8 mg/4ccAmp 4mg/2ccD: 3x/hariKI: HipersensitifP: Tukak lambungES: Diare, mual, muntahIO: amoksisilin, sefuroksim, doksisiklinPreg:: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 316: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCodeine HClAnalgesic, Narcotic; Centrally acting AntitussiveI: Manage pain of intercostal muscle strain + cough.BSO: Injection: 30 mg; 60 mg Solution, oral: 15 mg/5 mL Tablet: 15 mg, 30 mg, 60 mg D: 10-20 mg/dose PO q4-6h prn; max 120 mg/dPaed.2-6 years: 1-1.5 mg/kg/d PO divided q4-6h prn; max 30 mg/d 6-12 years: 1-1.5 mg/kg/d PO divided q4-6h prn; max 60 mg/d KI: Hipersensitif; high-altitude cerebral edema or elevated ICPIO: Toxicity increases with concurrent administration of TCAs, MAOIs, neuromuscular blockers, CNS depressants, phenothiazines, and narcotic analgesicsPreg: DP: Sedating; used to treat cough in high-altitude cerebral edema only if absolutely necessary; may depress hypoxic ventilatory rate and respiratory drive during sleep Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 317: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDextromethorphanAntitussiveI: Symptomatic relief of coughs caused by minor viral upper respiratory tract infections or inhaled irritants; most effective for a chronic nonproductive coughBSO: Syr 10 mg/5ccCapsule: 30 mg Liquid: 10 mg/15 mL, 3.5 mg/5 mL, 7.5 mg/5 mL, 15 mg/5 mL Liquid, sustained release, as polistirex 30 mg/5 mL Lozenges: 2.5 mg, 5 mg, 7.5 mg Syrup: 7.5 mg/mL, 10 mg/5 mL, 15 mg/15 mL D: <2 years: Use only as directed by a physician 2-6 y: 2.5-7.5 mg q4-8h; ext release:15 mg 2x/day, max 30mg/d 6-12 y: 5-10 mg q4h or 15 mg q6-8h; ext release:30 mg 2x/d, max 60 mg/dAdults: 10-20 mg q4h or 30 mg q6-8h; extended release: 60 mg 2x/d; max 120 mg/day KI: Hypersensitivity to dextromethorphan or any component

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 318: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexP: Research on chicken embryos exposed to concentrations of dextromethorphan relative to those typically taken by humans has shown to cause birth defects and fetal death; more study is needed, but it is suggested that pregnant women should be advised not to use dextromethorphan-containing medicationsES: <1%: Nausea, GI upset, constipation, abdominal discomfort IO: CYP2D6, 2E1, 3A3/4 enzyme substratePreg: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 319: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPseudoephedrineStimulates vasoconstriction by directly stimulating alpha-adrenergic receptors in respiratory mucosa. Used for symptomatic relief of nasal congestion due to common cold, upper respiratory tract allergies, and sinusitis. Promotes nasal or sinus drainage.BSO: Tab & Capsule: 30 mg, 60 mg Tab & Capsule, timed release: 120 mg Tab Extended release,: 120 mg, 240 mg Drops,: 7.5 mg/0.8 mL Syrup & Liquid,: 15 mg/5 mL; 30 mg/5 mL D:Immediate release: 30-60 mg PO q6hSustained release: 120 mg PO q12h; max 240 mg/24hPaed.<2 years: 4 mg/kg/d PO divided q6h2-5 years: 15 mg PO q6h; max 60 mg/24h6-12 years: 30 mg PO q6h; max 120 mg/24hKI:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 320: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexHipersensitif; severe anemia; postural hypertension or hypotension; closed-angle glaucoma; head trauma; cerebral hemorrhageIO:Propranolol, MAOIs, and sympathomimetic agents may increase toxicity; methyldopa and reserpine may reduce effectsPreg: CP:Cardiovascular disease, DM, prostatic hypertrophy, and increased intraocular pressure Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 321: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPhenylephrineStrong postsynaptic alpha-receptor stimulant with little beta-adrenergic activity that produces vasoconstriction of arterioles in the body.BSO: Injection: 1% [10 mg/mL]Nasal solution: Drops: 0.125%, 0.16%, 0.25%, 0.5% Spray: 0.25%, 0.5%, 1% Ophthalmic solution: 0.12%, 2.5%, 10%D:2-3 gtt or 1-2 sprays 0.25-0.5% solution each nostril or small quantity of 0.5% nasal jelly applied into each nostril q4h prn; 1% solution may be used in adults with severe congestionPaed.Infants >6 months: 1-2 gtt 0.16% solution each nostril q3h<6 years: 2-3 gtt or sprays 0.125% or 0.16% solution each nostril q4h prn6-12 years: 2-3 gtt 0.25% solution each nostril q4h prnKI:Hipersensitif; severe hypertension or ventricular tachycardia

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 322: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIO:Bretylium may potentiate action of vasopressors on adrenergic receptors, possibly resulting in arrhythmias; MAOIs may significantly enhance adrenergic effects of phenylephrine, and pressor response may be increased 2- to 3-foldGuanethidine may increase pressor response of direct-acting vasopressors, possibly resulting in severe hypertensionPreg: CP:Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block, or severe arteriosclerosis; in hypovolemia, use is not a substitute for replacement of blood, fluids and electrolytes, and plasma (promptly restore with loss); dilute IV and administer via large vein; extravasation P: requiredNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 323: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNoscapineI: Batuk tidak produktif, selesmaBSO: Kaps 25 mg, 50 mg.Tetes 10 mg/ccD: 25-50 mg 4x/hr Tetes:Dws 10 tts 3-4x/hrAnak 6-12 thn 5 tts 3-4x/hrBayi 2 tts 3-4x/hrKI: Asma bronchial, peningkatan TIK, depresi napas, penggunaan bersama MAOIP: Penykt hati & ginjal. Ketergantungan fisik pd penggunaan lamaES: IO: Preg: Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 324: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDiphenhydramine First-generation antihistamine with anticholinergic effects.BSO: Capsule & Tablet: 25 mg, 50 mg Elixir & Syrup: 12.5 mg/5 mL Injection: 10 mg/mL; 50 mg/mLLotion & Solution, topical spray: 1% Cream: 1%, 2% D: 25-50 mg PO q4-6h prn; max 400 mg/dPaed.<6 years: Not established6-12 years: 5 mg/kg/d PO divided tid/qid prn; max 300 mg/dKI:Hipersensitif; MAOI use; during asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer; severe hypertension; severe coronary artery diseaseIO:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 325: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPotentiates CNS effect of depressants; because of alcohol content, do not give syrup form to patient taking drugs that can cause disulfiramlike reactionsPreg: C P:Sedation and drowsiness may occur; may exacerbate angle-closure glaucoma, hyperthyroidism, peptic ulcer, or urinary tract obstruction and cause xerostomia Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 326: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCarbocisteineMucolyticI: Tracheostomy, Chronic obstructive pulmonary disease (COPD), Cystic fibrosis, Glue ear (suppurative otitis media)BSO: Kapl 375 mg, 500 mgSusp forte 500 mg/5ccSir 250 mg/5ccD: Dws 1 sdm 3x/hrAnak 5-12thn: 1 sdt 3x/hr2-5 thn: ½ sdt 4x/hrKI: Allergy, Peptic ulcersP: ES: Rash, Bleeding from the stomach or intestine, Diarrhoea, Nausea and vomitingIO: -Preg: Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 327: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexErdosteineI: D:KI: P: ES: IO: Preg:: A, B, C, D, X BSO: Nama Dagang:Vectrine

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 328: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLevodropropizineI: Terapi simtomatik batuk non produktifBSO: Syr 60 mg/5ccD: Dws & anak > 12 thn 3x 2 sdt. Interval min 6 jamKI: Hamil, laktasi, lender bronkus berlebihan P: ES: Mual, muntahIO: SedatifPreg: Nama Dagang:Levopront

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 329: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIsoaminileI: D:KI: P: ES: IO: Preg:: A, B, C, D, X BSO: Nama Dagang:Peracon

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 330: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTipepidine hibenzateI: Batuk, mukolitikBSO: Tab 33.21 mg

D: Dws 3x 1 tab . Kasus berat tambah 1 tab bedtime.Anak >6th ½ dosis dwsAnak < 6th 2.2 mg/kg/hr terbagi dlm 3 dosis.KI: P: ES: Kantuk, pusing, anoreksia, hausIO: Preg: Nama Dagang:Asvex

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 331: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexC. Dekongestan & Preparat Nasal LainOxymetazolineXylometazolineFexofenadine HClBeclomethasoneFluticasoneTriamcinolone acetonideMometasone furoateBudesonide

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 332: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexOxymetazoline Stimulates alpha-adrenergic receptors and causes vasoconstriction when applied directly to mucous membranes. Decongestion occurs without drastic changes in blood pressure, vascular redistribution, or cardiac stimulation.BSO: Solution, nasal: Drops, pediatric: 0.025%. Spray: 0.05%D:2-3 sprays or 2-3 gtt of 0.05% solution in each nostril bid, qam and qhs or q10-12hPaed.2-6 years: 2-3 gtt of 0.025% solution in each nostril bid, qam and qhsKI:Hipersensitif; MAOI therapyIO:Hypotensive action of guanethidine may be reversed; concurrent methyldopa may increase vasopressor response; concurrent MAOIs and ephedrine may result in hypertensive crisis; pressor sensitivity to mixed-acting agents (eg, ephedrine)

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 333: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexmay be increased; guanethidine potentiates effects of epinephrine and inhibits effects of ephedrine; phenothiazines may reverse action of nasal decongestants (eg, oxymetazoline); TCAs potentiate vasopressor response and may result in dysrhythmiasPreg: CP:Caution in hyperthyroidism, coronary artery and ischemic heart disease, DM, and increased intraocular pressure or prostatic hypertrophy; because of increase in vasoconstriction, hypertensive patients may have change in blood pressure; do not use topical decongestants for >3-5 d to avoid rebound phenomenon Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 334: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexXylometazoline Ophthalmic Agent, VasoconstrictorI: Symptomatic relief of nasal and nasopharyngeal mucosal congestionBSO: Solution, nasal: 0.05% [0.5 mg/mL]; 0.1% [1 mg/mL] D 2-12 years: Instill 2-3 drops (0.05%) in each nostril q8-10h Adults: Instill 2-3 drops or sprays (0.1%) in each nostril q8-10h KI: P: ES: 1% to 10%: Drowsiness, dizziness, seizures, headache, Blurred vision, ocular irritation, photophobia Miscellaneous: Sweating IO: Preg: C BSO: Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 335: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFexofenadineNonsedating AntihistamineI: Seasonal allergic rhinitis and chronic idiopathic urticariaBSO: Capsule: 60 mg Tablet: 30 mg, 60 mg, 180 mg D: Adults: 60 mg 2x/day or 180 mg 1x/day

Anak 6-11 thn: 30 mg 2x/hari.Suspension: Anak 2-11 thn: 30 mg 2x/hari, or 5 cc 2x/hari.Anak 6bln-2thn: 15 mg or 2.5 cc 2x/hari. KI: Hypersensitivity P: preg: & lactationES: Headache, Nausea, Dizziness, Fatigue, Drowsiness (rare) IO: Levels may increase with coadministration of erythromycin and ketoconazolePreg: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 336: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTriamcinolone acetonideCorticosteroid, Topical Potensi SedangI: Inhalation: Control of bronchial asthma and related bronchospastic conditions. Intranasal: Management of seasonal and perennial allergic rhinitis in patients greater than or equal to 12 years of age Systemic: Adrenocortical insufficiency, rheumatic disorders, allergic states, respiratory diseases, systemic lupus erythematosus, and other diseases requiring anti-inflammatory or immunosuppressive effects Topical: Inflammatory dermatoses responsive to steroids BSO: Semprot hidung 55 mcg/semprot. krim 0.1%D: 220 mcg (2 semprot tiap lubang hidung) 1x/hr Topikal: Oles 2-3x/hrKI: Known hypersensitivity to triamcinolone; systemic fungal infections; serious infections (except septic shock or tuberculous meningitis); primary treatment of status asthmaticus

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 337: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexES: Glaucoma, bronchospasm, epistaxis, Smell and taste disturbances, Irritation of the tissues in the nose, Dryness of the nose and throat, Stinging or burning at the area of applicationIO: Decreased effect: Barbiturates, phenytoin, rifampin metabolism of triamcinolone; vaccine and toxoid effects may be reduced Increased toxicity: Salicylates may increase risk of GI ulceration Preg: CNama Dagang:Nasacort AQ

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 338: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMometasone furoateMedium potency topical corticosteroidI: Hayfever & perennial allergic rhinitis. Nasal polyps in adults >18 years of age. Atopic dermatitis, PsoriasisBSO: Semprot hidung 50 mcg/dosis. Cream: 0.1%D: 100 mcg (2 semprot) 1x/hr each nostril. maxl 200 mcg/hrTopikal Oles 1x/hrKI: Nasal infections. < 6 years of age. Topikal: Acne vulgaris, acne rosacea.P: Active or inactive tuberculosis infection, Herpes simplex virus infection of the eyeES: Headache, epistaxis, pharyngitis, Nasal irritation, Nasal burning, Nasal ulceration, Smell or taste disturbancesTopikal: Thinning of the skin, Changes in skin pigmentation, paraesthesia, Acne, contact dermatitis, striae, hypertrichosis, folliculitis, Temporary burning and stinging on applicationPreg: CNama Dagang: Nasonex

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 339: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexD. Obat Pernapasan LainBeractant

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 340: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexBeractantLung SurfactantI: Prevention and treatment of respiratory distress syndrome (RDS) in premature infants Rescue therapy: Treatment of infants with RDS confirmed by x-ray and requiring mechanical ventilation (administer as soon as possible - within 8 hours of age) BSO: Suspension: 200 mgD: Prophylactic treatment: Administer 100 mg phospholipids (4 mL/kg) intratracheal as soon as possible; as many as 4 doses may be administered during the first 48 hours of life, no more frequently than 6 hours apart. The need for additional doses is determined by evidence of continuing respiratory distress; if the infant is still intubated and requiring at least 30% inspired oxygen to maintain a PaO2 less than or equal to 80 torr. Rescue treatment: Administer 100 mg phospholipids (4 mL/kg) as soon as the diagnosis of RDS is made; may repeat if needed, no more frequently than every 6 hours to a maximum of 4 doses

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 341: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexKI: P: Rapidly affects oxygenation and lung compliance and should be restricted to a highly supervised use in a clinical setting with immediate availability of clinicians experienced with intubation and ventilatory management of premature infants. If transient episodes of bradycardia and decreased oxygen saturation occur, discontinue the dosing procedure and initiate measures to alleviate the condition; produces rapid improvements in lung oxygenation and compliance that may require immediate reductions in ventilator settings and FiO2.ES: 1% to 10%: Respiratory: Oxygen desaturation IO: Preg:: A, B, C, D, X BSO: Nama Dagang: Survanta

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 342: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIV. NEURO MUSKULER

A. ANALGESIK & ANTIPIRETIKB. ANTI RHEUMATIK & ANALGESIK ANTI INFLAMASIC. PREPARAT GOUTD. ANTI KONVULSAN & ANTI EPILEPSYE. MINOR TRANSQUILIZER, ANXIETAS & RELAXANF. MAJOR TRANSQUILIZERG. HIPNOTIC & SEDATIFH. ANTI DEPRESSANI. STIMULAN SSP & OBAT ADHDJ. NOOTROPIK & NEUROTONIKK. ANTI EMETIK & ANTI VERTIGOL. PENYAKIT NEURODEGENERATIFM. PENYAKIT NEUROMUSKULARN. PREPARAT PARKINSONO. RELAKSAN OTOT

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 343: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexA. Analgesik & AntipiretikMorphinePethidineCodeine HClMeperidineMefenamic acid Acetaminophen/ ParacetamolAcetylsalicyclic acid/ Aspirin/ ASAMetamizole sodium/ MethampyroneKetorolacTramadolNaproxen

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 344: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAnalgesik NarcoticMorphineI: Relief of moderate to severe acute and chronic pain; pain of myocardial infarction; relieves dyspnea of acute left ventricular failure and pulmonary edema; preanesthetic medicationBSO: Capsule: 15 mg, 30 mg Capsule,: 20 mg, 50 mg, 100 mg Injection: 0.5 mg/mL; 1 mg/mL; 2 mg/mL; 3 mg/mL; 4 mg/mL; 5 mg/mL; 8 mg/mL; 10 mg/mL; 15 mg/mL; 25 mg/mL; 50 mg/mL Injection: Preservative free: 0.5 mg/mL; 1 mg/mL; 10 mg/mL; 25 mg/mL I.V. via PCA pump: 1 mg/mL; 5 mg/mL I.V. infusion preparation: 25 mg/mL Solution, oral: 10 mg/5 mL; 20 mg/5 mL, 20 mg/mL, 100 mg/5 mL, 10 mg/2.5 mL Suppository, rectal: 5 mg, 10 mg, 20 mg, 30 mg Tablet: 15 mg, 30 mg Controlled release: 15 mg, 30 mg, 60 mg, 100 mg, 200 mg

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 345: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSustained release: 30 mg, 60 mg, 100 mg D: Doses should be titrated to appropriate effect; when changing routes of administration in chronically treated patients, please note that oral doses are approximately one-half as effective as parenteral dose Oral: Tablet and solution (prompt release): 0.2-0.5 mg/kg/dose every 4-6 hours as needed; tablet (controlled release): 0.3-0.6 mg/kg/dose every 12 hours I.M., I.V., S.C.: 0.1-0.2 mg/kg/dose every 2-4 hours as needed; usual maximum: 15 mg/dose; may initiate at 0.05 mg/kg/dose I.V., S.C. continuous infusion: Sickle cell or cancer pain: 0.025-2 mg/kg/hour; postoperative pain: 0.01-0.04 mg/kg/hour Sedation/analgesia for procedures: I.V.: 0.05-0.1 mg/kg 5 minutes before the procedure Adolescents >12 years: Sedation/analgesia for procedures: I.V.: 3-4 mg and repeat in 5 minutes if necessary Adults: Oral: Prompt release: 10-30 mg every 4 hours as needed; controlled release: 15-30 mg every 8-12 hours

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 346: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexI.M., I.V., S.C.: 2.5-20 mg/dose every 2-6 hours as needed; usual: 10 mg/dose every 4 hours as needed I.V., S.C. continuous infusion: 0.8-10 mg/hour; may increase depending on pain relief/adverse effects; usual range: up to 80 mg/hour Epidural: Initial: 5 mg in lumbar region; if inadequate pain relief within 1 hour, administer 1-2 mg, maximum dose: 10 mg/24 hours Intrathecal (1/10 of epidural dose): 0.2-1 mg/dose; repeat doses not recommended Rectal: 10-20 mg every 4 hours Dosing adjustment in renal impairment:Clcr 10-50 mL/minute: Administer at 75% of normal dose Clcr <10 mL/minute: Administer at 50% of normal dose Dosing adjustment/comments in hepatic disease: Unchanged in mild liver disease; substantial extrahepatic metabolism may occur; excessive sedation may occur in cirrhosis

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 347: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexKI: hypersensitivity; increased intracranial pressure; severe respiratory depressionP: Some preparations contain sulfites which may cause allergic reactions; infants <3 months of age are more susceptible to respiratory depression, use with caution and generally in reduced doses in this age group; use with caution in patients with impaired respiratory function or severe hepatic dysfunction and in patients with hypersensitivity reactions to other phenanthrene derivative opioid agonists (codeine, hydrocodone, hydromorphone, levorphanol, oxycodone, oxymorphone). Morphine shares the toxic potential of opiate agonists and usual precautions of opiate agonist therapy should be observed; may cause hypotension in patients with acute myocardial infarction. Tolerance or drug dependence may result from extended use.ES: Percentage unknown: Flushing, CNS depression, drowsiness, sedation, increased intracranial pressure, antidiuretic hormone release, physical and psychological dependence, diaphoresis

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 348: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index>10%: Palpitations, hypotension, bradycardia, Dizziness, Nausea, vomiting, constipation, xerostomia, Pain at injection site, Weakness, Histamine release IO: CYP2D6 enzyme substrate Increased toxicity: CNS depressants, tricyclic antidepressants may potentiate the effects of morphine and other opiate agonists; dextroamphetamine may enhance the analgesic effect of morphine and other opiate agonists Preg: B, DNama Dagang: MST Continus

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 349: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPethidineopioid analgesics Opioids mimic the effects of naturally occurring pain relieving chemicals (endorphins). They bind to specific receptors in the brain and spinal cord called opioid receptors, which results in the blocking of transmission of pain signals. I: Moderate-severe pain. Pain relief during childbirth & surgeryBSO: D: KI: COPD, Convulsions, respiratory depression, comatose statesP: Neonates, Breathing problems, Convulsions, Diseases of the bile ducts, Elderly people, prostatic hypertrophy, Head injury, Hypothyroidism, tachycardia, raised intracranial pressure, acute alcoholism, adrenocortical insufficiency, Premature infants, shock, Severely decreased liver & kidney function, Weak or debilitated people

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 350: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexES: Changes in mood, Drowsiness, respiratory depression, dependence, Skin rashes, hypotension, hallucinations, Constipation, Nausea and vomitingIO: Opioids should not be taken concurrently with all MAOI anti-depressants (e.g. tranylcypromine and selegiline) and for two weeks after the MAOI antidepressant has been stopped.When taken together with other medicines that have a sedative effect on the central nervous system, for example alcohol, medicines that induce sleep (hypnotics), antidepressant and antihistamines, drowsiness is likely to be increased .Preg: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 351: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMeperidineAnalgesic, NarcoticI: Dental: Adjunct in preoperative IV conscious sedation in patients undergoing dental surgery; alternate oral narcotic in patients allergic to codeine to treat moderate to moderate-severe pain Medical: Management of moderate to severe pain; adjunct to anesthesia and preoperative sedation BSO: Injection,: Multiple-dose vials: 50 mg/mL; 100 mg/mL Injection, Single-dose: 10 mg/mL; 25 mg/dose; 50 mg/dose; 75 mg/dose; 100 mg/dose Syrup,: 50 mg/5 mL Tablet,: 50 mg, 100 mg D: Doses should be titrated to appropriate analgesic effect; when changing route of administration, note that oral doses are about half as effective as parenteral dose Adults: Oral, I.M., I.V.: S.C.: 50-150 mg/dose every 3-4 hours as needed Elderly:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 352: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexOral: 50 mg every 4 hours I.M.: 25 mg every 4 hours Dosing adjustment in renal impairment:Clcr 10-50 mL/minute: Administer at 75% of normal dose Clcr <10 mL/minute: Administer at 50% of normal dose Dosing adjustment/comments in hepatic disease: Increased narcotic effect in cirrhosis; reduction in dose more important for oral than I.V. route KI: Hypersensitivity to meperidine or any component; patients receiving MAO inhibitors presently or in the past 14 daysP: Use with caution in patients with pulmonary, hepatic, renal disorders, or increased intracranial pressure; use with caution in patients with renal failure or seizure disorders or those receiving high-dose meperidine; normeperidine (an active metabolite and CNS stimulant) may accumulate and precipitate twitches, tremors, or seizures; some preparations contain sulfites which may cause allergic reaction; not recommended as a drug of first choice for the treatment of chronic pain in the elderly due to the accumulation of normeperidine; for acute pain, its use should be

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 353: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexlimited to 1-2 doses; tolerance or drug dependence may result from extended useES: >10%: Hypotension, Fatigue, drowsiness, dizziness, Nausea, vomiting, constipation, Weakness, Histamine release 1-10%: Nervousness, headache, restlessness, malaise, confusion, Anorexia, stomach cramps, xerostomia, biliary spasm, Ureteral spasms, decreased urination, Pain at injection site, Dyspnea, shortness of breath IO: CYP2D6 enzyme substrate Increased toxicity: May aggravate the adverse effects of isoniazid; MAO inhibitors, fluoxetine, and other serotonin uptake inhibitors greatly potentiate the effects of meperidine; acute opioid overdosage symptoms can be seen, including severe toxic reactions; CNS depressants, tricyclic antidepressants, phenothiazines may potentiate the effects of meperidine Preg: B, DNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 354: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMefenamic acidNSAIDI: Short-term relief of mild-moderate pain including primary dysmenorrheaBSO: Capsule: 250 mgD: 500 mg to start then 250 mg q4 hours; max therapy: 1 week KI: HypersensitivityP: May have adverse effects on fetusES: Diarrhoea, constipation, nausea, vomiting or abdominal pain, Headache, Dizziness, Drowsiness, Skin rashes, Visual disturbances, fluid retention, oedema, palpitations, Ulceration of the stomach or intestines, pancreatitis, angioedema, bronchospasm, Kidney, liver or blood disordersIO: CYP2C9 enzyme substrate Increased effect/toxicity with oral anticoagulants, methotrexate Preg: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 355: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAcetaminophen/ ParacetamolActing directly on hypothalamic heat-regulating centers, which increases dissipation of body heat via vasodilation and sweating. D: 325-650 mg PO/PR q4-6h or 1000 mg tid/qid; max 4 g/d Paed.: 15 mg/kg PO/PR q4h prn; max 2.6 g/d KI: Hipersensitif IO:Rifampin can reduce analgesic effects; coadministration with barbiturates, carbamazepine, hydantoins, and isoniazid may increase hepatotoxicity; chronic use may potentiate effects of warfarin Preg: BP: Hepatotoxicity possible in those with chronic alcoholism following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; APAP is contained in many OTC products, and combined use with these products may result in cumulative APAP doses that exceed recommended maximum dose Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 356: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAspirin/ Acetylsalicylic Acid/ ASAI: Treatment of mild to moderate pain, inflammation, and fever; prophylaxis for myocardial infarction and transient ischemic episodes; management of rheumatoid arthritis, rheumatic fever, osteoarthritis, and gout (high dose)BSO: Suppository, rectal: 60 mg, 120 mg, 125 mg, 130 mg, 195 mg, 200 mg, 300 mg, 325 mg, 600 mg, 650 mg, 1.2 g Tablet: 65 mg, 75 mg, 81 mg, 325 mg, 500 mg D: Children: Analgesic and antipyretic: Oral, rectal: 10-15 mg/kg/dose q4-6h, max 60-80 mg/kg/day Anti-inflammatory: Oral: Initial: 60-90 mg/kg/day in divided doses; maintenance: 80-100 mg/kg/day divided q6-8h, maximum dose: 3.6 g/day; monitor serum concentrations Kawasaki disease: Oral: 80-100 mg/kg/day divided every 6 hours; after fever resolves: 8-10 mg/kg/day once daily; monitor serum concentrations Antirheumatic: Oral: 60-100 mg/kg/day in divided doses q4h Adults:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 357: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAnalgesic and antipyretic: Oral, rectal: 325-650 mg every 4-6 hours up to 4 g/day Anti-inflammatory: Oral: Initial: 2.4-3.6 g/day in divided doses; usual maintenance: 3.6-5.4 g/day; monitor serum concentrations TIA: Oral: 1.3 g/day in 2-4 divided doses Myocardial infarction prophylaxis: 160-325 mg/day; a lower aspirin dosage has been recommended in patients receiving ACE inhibitors KI: Hypersensitivity to salicylates or other NSAIDs; asthma; rhinitis; nasal polyps; inherited or acquired bleeding disorders (including factor VII and factor IX deficiency); pregnancy (in 3rd trimester especially); do not use in children (<16 years of age) for viral infections (chickenpox or flu symptoms), with or without fever, due to a potential association with Reye's syndromeP: Use with caution in patients with platelet and bleeding disorders, renal dysfunction, dehydration, erosive gastritis, or peptic ulcer disease. Heavy alcohol use (>3 drinks/day) can increase bleeding risks. Avoid use in severe renal failure or in

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 358: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexsevere hepatic failure. Discontinue use if tinnitus or impaired hearing occurs. Caution in mild-moderate renal failure (only at high dosages). Patients with sensitivity to tartrazine dyes, nasal polyps and asthma may have an increased risk of salicylate sensitivity. Surgical patients should avoid ASA if possible, for 1-2 weeks prior to surgery, to reduce the risk of excessive bleeding.ES: Hemorrhage, idiosyncratic, allergy, Hypotension, tachycardia, dysrhythmias, edema, Rash, angioedema, urticaria , Acidosis, hyperkalemia, dehydration, hypoglycemia (children), hyperglycemia, hypernatremia (buffered forms), Nausea, vomiting, dyspepsia, epigastric discomfort, heartburn, stomach pains, gastrointestinal ulceration (6% to 31%), gastric erosions, gastric erythema, duodenal ulcers, Anemia, D.I.C , prolongation of prothrombin times, coagulopathy, thrombocytopenia, hemolytic anemia, bleeding, iron deficiency anemia , Hepatotoxicity, increased transaminases, hepatitis (reversible) Neuromuscular and skeletal: Rhabdomyolysis, weakness, acetabular bone destruction (OA)

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 359: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexOtic: Hearing loss, tinnitus Renal: Interstitial nephritis, papillary necrosis, proteinuria, renal impairment, renal failure (including cases caused by rhabdomyolysis), increased BUN, increased serum creatinine Respiratory: Asthma, bronchospasm, dyspnea, laryngeal edema, hyperpnea, tachypnea, respiratory alkalosis, noncardiogenic pulmonary edema Miscellaneous: Anaphylaxis, prolonged pregnancy and labor, stillbirths, low birth weight, peripartum bleeding, Reye's syndrome Case reports: Colonic ulceration, esophageal stricture, esophagitis with esophageal ulcer, esophageal hematoma, oral mucosal ulcers (aspirin-containing chewing gum), coronary artery spasm, conduction defect and atrial fibrillation (toxicity), delirium, ischemic brain infarction, colitis, rectal stenosis (suppository), cholestatic jaundice, periorbital edema, rhinosinusitis IO: ACE inhibitors: The effects of ace inhibitors may be blunted by aspirin administration, particularly at higher dosages.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 360: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexBuspirone increases aspirin's free % in vitro. Carbonic anhydrase inhibitors and corticosteroids have been associated with alteration in salicylate serum concentrations. Heparin and low molecular weight heparins: Concurrent use may increase the risk of bleeding. Methotrexate serum levels may be increased; consider discontinuing aspirin 2-3 days before high-dose methotrexate treatment or avoid concurrent use. NSAIDs may increase the risk of gastrointestinal adverse effects and bleeding. Serum concentrations of some NSAIDs may be decreased by aspirin. Platelet inhibitors (IIb/IIa antagonists): Risk of bleeding may be increased. Probenecid effects may be antagonized by aspirin. Sulfonylureas: The effects of older sulfonylurea agents (tolazamide, tolbutamide) may be potentiated due to displacement from plasma proteins. This effect does not appear to be clinically significant for newer sulfonylurea agents (glyburide, glipizide, glimepiride).

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 361: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexValproic acid may be displaced from its binding sites which can result in toxicity. Verapamil may potentiate the prolongation of bleeding time associated with aspirin. Warfarin and oral anticoagulants may increase the risk of bleeding.

Preg: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 362: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMetamizole sodium/ MethampyroneI: Neuralgia, sakit kepala, berbagai nyeriBSO: Kapl & Tab 500 mgAmp 1g/2ccD: Tab 500 mg- 1g 3-4x/hr. max 2 g/hr Inj 500 mg 3-4x/hr IM/IVKI: Perdarahan, porfiria, psikosis beratP: ES: Kantuk, ketergantungan, ggn penglihatan, hipotensi, agranulositosisIO: KlorpromazinPreg:Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 363: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexKetorolacNSAIDI: Short-term (<5 days) management of pain; first parenteral NSAID for analgesia; 30 mg provides the analgesia comparable to 12 mg of morphine or 100 mg of meperidine BSO: Injection: 10 mg/cc, 30 mg/mL Solution, ophthalmic: 0.5%Tablet: 10 mg D: Note: The use of ketorolac in children <16 years of age is outside of product labeling Single-dose treatment: I.M., I.V.: 0.4-1 mg/kg as a single dose; Note: Limited information exists. Single I.V. doses of 0.5 mg/kg, 0.75 mg/kg, 0.9 mg/kg and 1 mg/kg have been studied in children 2-16 years of age for postoperative analgesia. One study (Maunuksela, 1992) used a titrating dose starting with 0.2 mg/kg up to a total of 0.5 mg/kg (median dose required: 0.4 mg/kg).

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 364: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexOral: One study used 1 mg/kg as a single dose for analgesia in 30 children (mean ± SD age: 3 ± 2.5 years) undergoing bilateral myringotomy Multiple-dose treatment: I.M., I.V., Oral: No pediatric studies exist; one report (Buck, 1994) of the clinical experience with ketorolac in 112 children, 6 months to 19 years of age (mean: 9 years), described usual I.V. maintenance doses of 0.5 mg/kg every 6 hours (mean dose: 0.52 mg/kg; range: 0.17-1 mg/kg) Adults (pain relief usually begins within 10 minutes with parenteral forms): Oral: 10 mg every 4-6 hours as needed for a maximum of 40 mg/day; on day of transition from I.M. to oral: maximum oral dose: 40 mg (or 120 mg combined oral and I.M.); maximum 5 days administration I.M.: Initial: 30-60 mg, then 15-30 mg every 6 hours as needed for up to 5 days maximum; maximum dose in the first 24 hours: 150 mg with 120 mg/24 hours for up to 5 days total

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 365: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexI.V.: Initial: 30 mg, then 15-30 mg every 6 hours as needed for up to 5 days maximum; maximum daily dose: 120 mg for up to 5 days total Ophthalmic: Instill 1 drop in eye(s) 4 times/day for up to 7 days Elderly >65 years: Renal insufficiency or weight <50 kg: I.M.: 30 mg, then 15 mg every 6 hours I.V.: 15 mg every 6 hours as needed for up to 5 days total; maximum daily dose: 60 mg KI: In patients who have developed nasal polyps, angioedema, or bronchospastic reactions to other NSAIDs, active peptic ulcer disease, recent GI bleeding or perforation, patients with advanced renal disease or risk of renal failure, labor and delivery, nursing mothers, patients with hypersensitivity to ketorolac, aspirin, or other NSAIDs, prophylaxis before major surgery, suspected or confirmed cerebrovascular bleeding, hemorrhagic diathesis, concurrent ASA or other NSAIDs, epidural or intrathecal administration, concomitant probenecidP: Use extra caution and reduce dosages in the elderly because it is cleared renally somewhat slower, and the elderly are also

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 366: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexmore sensitive to the renal effects of NSAIDs; use with caution in patients with congestive heart failure, hypertension, decreased renal or hepatic function, history of GI disease (bleeding or ulcers), or those receiving anticoagulantsES: Renal impairment, wound bleeding (with I.M.), postoperative hematomas 1- 10%: Edema, Drowsiness, dizziness, headache, pain, Nausea, dyspepsia, diarrhea, gastric ulcers, indigestion, Pain at injection site, Diaphoresis (increased) IO: Decreased effect of diuretics Increased toxicity: Lithium, methotrexate increased drug level; increased effect/toxicity with salicylates, probenecid, anticoagulants Preg: B, D hamil trim 3Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 367: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTramadolAnalgesic, Non-narcoticI:Inhibits ascending pain pathways, altering perception of and response to pain. Also inhibits reuptake of norepinephrine and serotonin.BSO: Tab: 50 mg, 100 mgD: 50-100 mg PO q4-6h; max 400 mg/dKI: Hipersensitif; opioid-dependency; concurrent use of MAOIs or within 14 d; use of SSRIs, TCAs, or opioids or acute alcohol intoxicationIO: Decreases carbamazepine effects; cimetidine increases toxicity, risk of serotonin syndrome with coadministration of antidepressantsPreg: CP: Dizziness, nausea, constipation, sweating, or pruritus; additive sedation with alcohol and TCAs; abrupt discontinuation can precipitate opioid withdrawal symptoms; adjust dose in liver disease, myxedema, hypothyroidism, or hypoadrenalism; Preg:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 368: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexand breastfeeding; seizure; development of tolerance or dependency with extended use Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 369: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNaproxen NaNSAIDI: Management of inflammatory disease and rheumatoid disorders (including juvenile rheumatoid arthritis); acute gout; mild to moderate pain; dysmenorrhea; fever, migraine headache BSO: Suspension, oral: 125 mg/5 mL Tablet: 220 mg;275 mg;550 mg,200 mg,250 mg,375mg,500mg Tablet, controlled release: 375 mg, 500 mg D: Oral: Fever: 2.5-10 mg/kg/dose; maximum: 10 mg/kg/day Juvenile arthritis: 10 mg/kg/day in 2 divided doses Adults: RA, OA and ankylosing spondylitis: 500-1000 mg/day in 2 divided doses; may increase to 1.5 g/day of naproxen base for limited time period Mild to moderate pain or dysmenorrhea: Initial: 500 mg, then 250 mg every 6-8 hours; maximum: 1250 mg/day naproxen base

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 370: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDosing adjustment in hepatic impairment: Reduce dose to 50%

KI: Hypersensitivity to naproxen, aspirin, or other nonsteroidal anti-inflammatory drugs (NSAIDs)P: Use with caution in patients with GI disease (bleeding or ulcers), cardiovascular disease (CHF, hypertension), dehydration, renal or hepatic impairment, and patients receiving anticoagulants; perform ophthalmologic evaluation for those who develop eye complaints during therapy (blurred vision, diminished vision, changes in color vision, retinal changes); NSAIDs may mask signs/symptoms of infections; photosensitivity reported; elderly are at especially high-risk for adverse effectsES: Diarrhoea, constipation, nausea, vomiting or abdominal pain, Headache, Dizziness, insomnia, vertigo, tinnitus, Skin reactions such as rash or itching, Ulceration or bleeding of the stomach or intestines, fluid retention, oedema, Increase in blood pressure, Visual disturbances, Drowsiness, Concentration

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 371: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexdifficulties, Depression, Seizures (convulsions), bronchospasm, angioedema, itchy blistering rash or anaphylactic shock, photosensitivity, Kidney, liver or blood disordersIO: CYP2C8, 2C9, and 2C18 enzyme substrate Increased toxicity: Naproxen could displace other highly protein bound drugs, such as oral anticoagulants, hydantoins, salicylates, sulfonamides, and sulfonylureas Naproxen and warfarin may cause a slight increase in free warfarin Naproxen and probenecid may cause increased plasma half-life of naproxen Naproxen and methotrexate may significantly increase and prolong blood methotrexate concentration, which may be severe or fatal Preg: B, D hamil trim 3 Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 372: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexB. Anti Rheumatik & Analgesik Anti InflamasiPiroxicam MeloxicamTenoxicam NaproxenIbuprofen DiclofenacKetoprofen EtodolacSulfasalazine IndometacinLoxoprofen PhenylbutazoneOxyphenbutazone DexketoprofenFenbufen NabumetoneCelecoxib ValdecoxibEtoricoxib EtanerceptParecoxib TinoridineSodium hyaluronate/ Hyaluronic acidNimesulide InfliximabRituximabGlucosamine, Chondroitin sulphateDiacereinLeflunomide

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 373: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPiroxicamNSAIDI: Management of inflammatory disorders; symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis; also used to treat sunburnBSO: Tab 10 mg, 20 mg. Vial IM 20 mg. Supp 20 mgGel 0.5 %D: 10-20 mg/d PO. 0.2-0.3 mg/kg/d PO; max 15 mg/d

Gel: oles 3-4x/hr KI: Hypersensitivity; active GI bleedingP: Use with caution in patients with impaired cardiac function, dehydration, hypertension, impaired renal function, GI disease (bleeding or ulcers) and patients receiving anticoagulants; elderly have increased risk for adverse reactions to NSAIDsES: Indigestion, diarrhoea, constipation, nausea, vomiting or abdominal pain, Loss of appetite, flatulence, Skin reactions such as rash or itching, photosensitivity, Ulceration of the

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 374: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexstomach or intestines, Bleeding from the stomach or intestines, fluid retention), resulting in swelling (oedema), Dizziness, Headache, Sleepiness, Difficulty sleeping, Depression, Confusion, vertigo, tinnitus, Blurred vision, angioedema, bronchospasm, Kidney, liver or blood disorders.IO: Preg: C, D Hamil trim 3 Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 375: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMeloxicamTo some extent, more selective for COX-2 receptors, compared to traditional NSAIDs. Decreases activity of cyclooxygenase, which in turn inhibits prostaglandin synthesis. These effects decrease formation of inflammatory mediators.I: Relief of signs and symptoms of osteoarthritisBSO: Tablet: 7.5 mg, 15 mg. Supp 15 mgAmp 15 mg/1.5 ccD: 7.5 mg PO qd prn (1x/hr); may increase to 15 mg PO qd prnKI: Hipersensitif; active GI bleedingIO: Coadministration with aspirin increases risk of inducing serious NSAID-related adverse effects; probenecid may increase concentrations and, possibly, toxicity of NSAIDs; may decrease effect of hydralazine, captopril, and beta-blockers; may decrease diuretic effects of furosemide and thiazides; may increase PT when taking anticoagulants (instruct patients to watch for signs of bleeding); may increase risk of methotrexate

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 376: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indextoxicity; phenytoin levels may be increased when administered concurrentlyPreg: C, D hamil trim 3 P:Category D in third trimester of Preg:; acute renal insufficiency, hyperkalemia, hyponatremia, interstitial nephritis, and renal papillary necrosis may occur; increases risk of acute renal failure in patients with preexisting renal disease or compromised renal perfusion; reversible leukopenia may occur, (discontinue if there is persistent leukopenia, granulocytopenia, or thrombocytopenia)NSAID labeling carries a warning about increased risk of hypertension, stroke, and cardiovascular events, including myocardial infarctionNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 377: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTenoxicamNSAID. Blocking the production of prostaglandin which the body produces in response to injury or certain diseases. prostaglandin go on to cause swelling, pain and inflammation. I: Arthritis, myalgia, PainBSO: Tab salut selaput 20 mg

D: 20 mg 1x/hr Gout akut: Hr 1-2: 40 mg 1x/hr. 5 hr berikutnya 20 mg/hrKI: Allergy, Peptic ulcers, Ulcer caused by NSAIDP: Asthma, Children, Elderly, Heart, Kidney & liver diseaseES: Rash, Abdominal pain, Diarrhoea, Nausea, dyspepsia, Ulceration & Bleeding of the stomach or intestine, fluid retention, Dizziness, Blood disorders, Kidney disease, pancreatitis, photosensitivity, toxic epidermal necrolysis, bronchospasm, Damage to the liverPreg:: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 378: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNaproxenNSAIDI: For relief of mild to moderate pain; inhibits inflammatory reactions and pain by decreasing activity of cyclooxygenase, which results in decrease of prostaglandin synthesis.BSO: Tab 250 mg. Kapl 500 mg. supp 500 mgSuspension, oral: 125 mg/5 mL Gel 0.1 g/gD: 500 mg PO followed by 250 mg PO q6-8h; max 1.25 g/dPaed.>2 years: 2.5 mg/kg/dose PO; max 10 mg/kg/dGel: Oles 2x/hr max6x/hrKI: Hipersensitif; peptic ulcer disease; recent GI bleeding or perforation; renal insufficiencyIO:Coadministration with aspirin increases risk of inducing serious NSAID-related adverse effects; probenecid may increase concentrations and, possibly, toxicity of NSAIDs; may decrease effects of hydralazine, captopril, and beta-blockers; may

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 379: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexdecrease diuretic effects of furosemide and thiazides; may increase PT when taking anticoagulants (instruct patients to watch for signs of bleeding); may increase risk of methotrexate toxicity; phenytoin levels may be increased when administered concurrentlyPreg: B, D hamil trim 3P:Category D in third trimester of Preg:; acute renal insufficiency, interstitial nephritis, hyperkalemia, hyponatremia, and renal papillary necrosis may occur; patients with preexisting renal disease or compromised renal perfusion risk acute renal failure; leukopenia occurs rarely, is transient, and usually returns to normal during therapy; persistent leukopenia, granulocytopenia, or thrombocytopenia warrants further evaluation and may require discontinuation of drug Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 380: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIbuprofenDOC for patients with mild-moderate pain. Inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis.BSO: Caplet: 100 mg Drops, oral: 40 mg/mL Suspension, oral: 100 mg/5 mL Suspension, oral, drops: 40 mg/mL; 50 mg/1.25 mL Tablet: 100 mg, 200 mg, 300 mg, 400 mg, 600 mg, 800 mg Tablet, chewable: 50 mg, 100 mg D: 400 mg PO q4-6h; max 3.2 g/dKI:Hipersensitif; peptic ulcer disease; recent GI bleeding or perforation; renal insufficiency; high risk of bleedingIO:Coadministration with aspirin increases risk of inducing serious NSAID-related adverse effects; probenecid may increase concentrations and, possibly, toxicity of NSAIDs; may decrease effects of hydralazine, captopril, and beta-blockers; may decrease diuretic effects of furosemide and thiazides; may

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 381: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexincrease PT when taking anticoagulants (instruct patients to watch for signs of bleeding); may increase risk of methotrexate toxicity; phenytoin levels may be increased when administered concurrentlyPreg: B, D pd trim III atau menjelang partusP:Category D in third trimester of Preg:; caution in congestive heart failure, hypertension, and decreased renal and hepatic function; caution in coagulation abnormalities or during anticoagulant therapy Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 382: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDiclofenacInhibits prostaglandin synthesis by decreasing activity of enzyme cyclooxygenase, which in turn decreases formation of prostaglandin precursors.BSO: Solution, ophthalmic,: 0.1% Tablet, enteric coated: 25 mg, 50 mg, 75 mg Tablet, delayed release: 25 mg, 50 mg, 75 mg Tablet, extended release: 100 mg GelD: 50 mg PO tid; max 150 mg/dKI:Hipersensitif; peptic ulcer disease; recent GI bleeding or perforation; renal insufficiency; high risk of bleedingIO:Coadministration with aspirin increases risk of inducing serious NSAID-related adverse effects; probenecid may increase concentrations and, possibly, toxicity of NSAIDs; may decrease effects of hydralazine, captopril, and beta-blockers; may decrease diuretic effects of furosemide and thiazides; may

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 383: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexincrease PT when taking anticoagulants (instruct patients to watch for signs of bleeding); may increase risk of methotrexate toxicity; phenytoin levels may be increased when administered concurrentlyPreg: BP:Category D in third trimester of Preg:; acute renal insufficiency, hyperkalemia, hyponatremia, interstitial nephritis, and renal papillary necrosis may occur; increases risk of acute renal failure in patients with preexisting renal disease or compromised renal perfusion; low WBC counts occur rarely and usually return to normal in ongoing therapy; discontinuation of therapy may be necessary if persistent leukopenia, granulocytopenia, or thrombocytopenia Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 384: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexKetoprofenRelief of mild to moderate pain and inflammation. BSO: Tab salut enteric 50 mg, 100 mgTab OD 200 mgSupp 100 mg Amp: 50 mg/cc, 100 mg/ 2ccGel 2.5 %D: 25-50 mg PO q6-8h prn; max 300 mg/dGel: oles 2-3x/hr max 7 hariKI: HipersensitifIO:Coadministration with aspirin increases risk of inducing serious NSAID-related adverse effects; probenecid may increase concentrations and, possibly, toxicity of NSAIDs; may decrease effects of hydralazine, captopril, and beta-blockers; may decrease diuretic effects of furosemide and thiazides; may increase PT when taking anticoagulants (instruct patients to watch for signs of bleeding); may increase risk of methotrexate

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 385: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indextoxicity; phenytoin levels may be increased when administered concurrentlyPreg:B - Usually safe but benefits must outweigh the risks. D Hamil trim 3P:Category D in third trimester of Preg:; caution in congestive heart failure, hypertension, and decreased renal and hepatic function; caution in coagulation abnormalities or during anticoagulant therapyNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 386: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexEtodolacNSAIDI: Rheumatoid arthritis, Osteoarthritis.BSO: Capsule: 200 mg, 300 mg Tablet: 400 mg, 500 mg D: Single dose of 76-100 mg is comparable to the analgesic effect of aspirin 650 mg; in patients greater than or equal to 65 years, no substantial differences in the pharmacokinetics or side-effects profile were seen compared with the general population Acute pain: 200-400 mg every 6-8 hours, as needed, max total daily doses of 1200 mg; for patients weighing <60 kg, total daily dose should not exceed 20 mg/kg/day Osteoarthritis: Initial: 800-1200 mg/day given in divided doses: 400 mg 2 or 3 times/day; 300 mg 2, 3 or 4 times/day; 200 mg 3 or 4 times/day; total daily dose should not exceed 1200 mg; for patients weighing <60 kg, total daily dose should not exceed 20 mg/kg/day

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 387: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexKI: Allergic reactions, peptic ulcer or bleeding from the gut, Severe heart failure, Pregnancy, Breastfeeding, children.P: Elderly people, History of disorders affecting the stomach or intestines, Inflammatory bowel disease such as Crohn's disease or ulcerative colitis, Kidney & Liver disease, Heart failure, ischaemic heart disease, cerebrovascular disease, Poor circulation in the arteries of the legs or feet (peripheral arterial disease), hypertension, hyperlipidaemia, Diabetes, Smokers, History of asthma, People taking anticoagulant medicines ES: Indigestion, diarrhoea, constipation, nausea, vomiting or abdominal pain, flatulence, stomatitis, Headache, Dizziness, Visual disturbances, Skin reactions such as rash and itch, photosensitivity, insomnia, Drowsiness, Confusion, Depression, fluid retention, oedema, tinnitus, dyspnoea, Ulceration or bleeding in the stomach or intestines, angioedema, bronchospasm, Kidney, liver or blood disorders.IO: Decreased effect with aspirin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 388: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIncreased effect/toxicity with aspirin (GI irritation), probenecid; increased effect/toxicity of lithium, methotrexate, digoxin, cyclosporin (nephrotoxicity), warfarin (bleeding)

Preg: C, D hamil trim 3Nama Dagang:Lonene

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 389: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIndomethacinNSAIDI: RA, OA, ankylosing spondylitis, Acute gout, tendinitis, bursitis, tenosynovitis, capsulitis, Painful disorders of the muscles and skeleton, Lower back pain, Pain and inflammation following orthopaedic (bone) surgery or other orthopaedic procedures, Dysmenorrhea)BSO: Kaps 100 mg

D: 200 mg 2x/hr KI: Children, allergic reactions, Active peptic ulcer or bleeding from the gut, Severe heart failure, Pregnancy, Breastfeeding.P: Elderly people, History of disorders affecting the stomach or intestines, Inflammatory bowel disease such as Crohn's disease or ulcerative colitis, Decreased kidney & liver function, Heart failure, hypertension, History of asthma & allergies, People with blood clotting disorders or taking anticoagulants, Epilepsy, Parkinson's disease, Psychiatric disorders

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 390: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexES: Headache, Dizziness, indigestion, nausea, vomiting, diarrhoea or abdominal pain, Ulceration or bleeding in the stomach or intestines, fluid retention, oedema, Rise in blood pressure, Change in heart rate or rhythm, Hair loss, vertigo, tinnitus, Confusion, Depression, Anxiety, Fatigue, insomnia, Pins and needles sensations, Eye pain, Blurred vision, Allergy, Kidney, liver or blood disordersIO: CYP2C9 enzyme substrate Increased toxicity: May increase serum potassium with potassium-sparing diuretics; probenecid may increase indomethacin serum concentrations; other NSAIDs may increase GI adverse effects; may increase nephrotoxicity of cyclosporin Indomethacin may increase serum concentrations of digoxin, methotrexate, lithium, and aminoglycosides (reported with I.V. use in neonates) Preg: B, D if used >48 hours or after 34-week gestation Nama Dagang: Dialon

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 391: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLoxoprofenI: AR, OA, nyeri punggung, periartritis skapulo-humoral & sindroma leher-bahu & lenganBSO: Tab 60 mgD: Dws 60 mg 3x/hr atau dosis tunggal 60-120 mg tgt umur &

beratnya gejala. KI: Tukak peptik, ggn hematologi berat. Hamil trim akhir, laktasiP: Usia lanjut, hamilES: syok, anemia hemolitik, sindr mukokutaneus okular, ggl ginjal akut, sindr nefrotikIO: Antikoagulan kumarin, kuinolon, antimikrobaPreg:: A, B, C, D, X Nama Dagang:Loxonin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 392: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPhenylbutazoneI: AR, Demam rematik, tendonitis, bursitis, sinovitis, gout akut, tromboflebitis superfisialBSO: Kapl & Kaps 100 mg, 200 mg

D: Awal 300-600 mg/hr terbagi dlm 3-4 dosisKI: Edema,dekompensasi kordis, tukak lambung, riwayat diskrasia darah, anak < 14 thn, ggn hati & ginjalP: Usia lanjut, hamil & laktasiES: Mual, muntah, ggn epigastrium, hematuria, penglihatan kabur IO: antikoagulan, insulin, hipoglikemik oralPreg: C, D hamil trim 3Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 393: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexOxyphenbutazoneNSAIDI: Management of inflammatory disorders, as an analgesic in the treatment of mild to moderate pain; acute gouty arthritisBSO: Tablet: 100 mg, 200 mg

D: Acute gout: 1st 400 mg then 100 mg q4h. max 7dayKI: Active GI bleeding; ulcer disease; hypersensitivity to oxyphenbutazone or any componentP: ES: >10%: Dizziness, Skin rash, Abdominal cramps, heartburn, indigestion, nausea 1% to 10%: Headache, nervousness, Itching, Fluid retention, Vomiting, Tinnitus IO: Preg: DBSO: Nama Dagang: Reozon

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 394: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDexketoprofenNSAIDI: Pain in muscles, bones/ joints, dysmenorrhea, ToothacheBSO: Tab salut selaput 25 mg

D: 12.5 mg 3-4x/hr atau 25 mg 3x/hr. Maks 75 mg.KI: Children, allergic, asthma, peptic ulcer, Crohn's disease, Ulcerative colitis, Pregnancy, Breastfeeding.P: Elderly people, Dehydration, History of disorders affecting the stomach or intestines, hypertension, History of allergiesES: Indigestion, nausea, vomiting, constipation, diarrhoea, heartburn, abdominal pain, Headache, Dizziness, insomnia, vertigo, Palpitations, Fatigue, Flushing, Dry mouth, fluid retention, oedema, Changes in blood pressure, Ulceration of the stomach or intestine, bronchospasm, photosensitivity, Visual disturbances, tinnitusPreg:: A, B, C, D, X Nama Dagang: Ketesse

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 395: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFenbufenNSAIDI: Rheumatoid arthritis, ankylosing spondylitis, Osteoarthritis, Painful disorders of the muscles and skeleton, such as tendinitis, sprains, strains, dislocations, fractures, back painBSO: Kaps 300 mg

D: Rematik: 600-900 mg 2-3x/hr. Max 1200 mg/hrAnalgesik: 400 mg 2x/hr atau 300 mg 3x/hr KI: Allergic reactions, Active peptic ulcer or bleeding from the gut, Severe heart failure, children < 14 years of age.P: Elderly people, Inflammatory bowel disease such as Crohn's disease or ulcerative colitis, Heart failure, hypertension, History of asthma & allergies, People with blood clotting disorders or taking anticoagulant medicines, Diseases affecting connective tissue, eg SLEES: Indigestion, diarrhoea, constipation, nausea, vomiting or abdominal pain, Rash, Headache, Dizziness, insomnia, tinnitus,

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 396: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexvertigo, Visual disturbances, Ulceration of the stomach or intestines, Bleeding from the stomach or intestines, fluid retention, oedema, photosensitivity, Hypersensitivity reactions, Kidney, liver or blood disorders, Lung disordersIO: Preg:: A, B, C, D, X Nama Dagang:Cybufen

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 397: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNabumetoneNSAIDI: Inflammation of joints (arthritis)BSO: Tablet: 500 mg, 750 mg

D: 500-1000 mg 1-2x/day Max 1 g/hrKI: Allergy, Peptic ulcers, Severe liver diseaseP: Asthma, Children, Elderly people, Heart disease, hypertension, Kidney disease, Liver diseaseES: Abdominal pain, Diarrhoea, Nausea, dyspepsia, Ulceration of the stomach or intestine, Rash (allergic reaction), fluid retention, Dizziness or loss of balance, Kidney disease, pancreatitis, photosensitivity, toxic epidermal necrolysis, bronchospasm, angioedemaIO: Aspirin decreases serum concentrations probably by protein-binding displacement; there is an increased bleeding potential with concomitant warfarin therapy; may increase lithium and methotrexate concentrations by decreasing renal clearance; may decrease diuretic and hypotensive effects of

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 398: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexthiazides, loop diuretics, ACE inhibitors, and beta-blockers; may increase nephrotoxicity of cyclosporinePreg: C, D hamil trim 3 Nama Dagang: Goflex

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 399: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCelecoxibPrimarily inhibits COX-2. COX-2 is considered an inducible isoenzyme, induced by pain and inflammatory stimuli. Inhibition of COX-1 may contribute to NSAID GI toxicity. At therapeutic concentrations, COX-1 isoenzyme is not inhibited, thus GI toxicity may be decreased. Seek lowest dose of celecoxib for each patient. Celecoxib has the same general class labeling as conventional NSAIDs.BSO: Kaps 100 mg, 200 mgD: 100 mg PO qd/bid (1-2x/hr)KI: HipersensitifIO:Coadministration with fluconazole may cause increase in celecoxib plasma concentrations because of inhibition of celecoxib metabolism; coadministration of celecoxib with rifampin may decrease celecoxib plasma concentrationsPreg: BP:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 400: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMay cause fluid retention and peripheral edema; caution in compromised cardiac function, hypertension, and conditions predisposing to fluid retention; severe heart failure and hyponatremia may occur because celecoxib may deteriorate circulatory hemodynamics; NSAIDs may mask usual signs of infection; caution in the presence of existing controlled infections; evaluate symptoms and signs suggesting liver dysfunctionNama Dagang: Celebrex

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 401: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexValdecoxibNSAIDI: RA, OA, dysmenorrhoeaBSO: Tab salut selaput 10 mgD: OA &RA 10-20 mg 1x/hr. Max 20 mgDismenore primer 40 mg 1x/hr. Tambahan 40 mg dpt diberikan

pd hari I . KI: Allergy, Active peptic ulcer, Bleeding from the stomach or intestines, Inflammatory bowel disease such as ulcerative colitis or Crohn's disease, People who have had coronary artery bypass graft (CABG) surgery, Moderate to severe heart failure, ischaemic heart disease, cerebrovascular disease, Severely decreased liver function, Third trimester of pregnancy, Breastfeeding, P: Elderly people, Moderately decreased liver function, Decreased kidney function, fluid retention, Dehydration, History of diseases of the stomach or intestines, History of ulceration or bleeding in the stomach or intestines, hypertension,

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 402: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexhyperlipidaemia, Diabetes, Smokers, Narrowing of the arteries in the extremities (peripheral arterial disease)ES: Abdominal pain and bloating, diarrhoea, nausea, indigestion, Dry mouth, insomnia, somnolence, hypertension, Cough, pharyngitis, sinusitis, Urinary tract infection, peripheral oedema, Rash or itching, anaemia, Dry socket following a tooth extraction, Blurred vision, Pins and needles or numb sensations, Anxiety, Confusion, Ulceration or bleeding of the stomach or intestines, heart failure, Severe skin reactionsIO: If you are taking anti-blood-clotting medicines (anticoagulants) such as warfarin, you should have your blood clotting time (INR) monitored if you start or stop treatment with valdecoxib, or if your dose is changed.Valdecoxib may be taken with low-dose (75mg daily) aspirin. However, this combination may carry an increased risk of ulceration or bleeding in the stomach or intestines compared to taking valdecoxib on its own. Valdecoxib should not be taken with higher daily doses of aspirin. For more information and advice ask your doctor or pharmacist.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 403: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexValdecoxib should not be taken with other non-steroidal anti-inflammatory drugs (NSAIDs), eg ibuprofen, diclofenac, as using more than one NSAID together may also increase the risk of side effects on the gut.Valdecoxib may potentially decrease the effectiveness of medicines used for lowering high blood pressure (antihypertensives).There may be an increased risk of side effects on the kidney if valdecoxib is taken with any of the following medicines, and your kidney function should be monitored if you are taking any of these medicines with valdecoxib: * ACE inhibitors, eg enalapril * ciclosporin * diuretics, eg bendroflumethiazide, furosemide * tacrolimus.The following medicines may increase the blood level of valdecoxib, and your doctor may prescribe a lower dose of valdecoxib if you are taking one of these medicines:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 404: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index * fluconazole * ketoconazole.The following medicines may decrease the blood level of valdecoxib: * antiepileptics, eg carbamazepine, phenytoin * dexamethasone * rifampicin.Valdecoxib may increase the blood levels of the following medicines: * flecainide * propafenone * metoprolol * omeprazole * phenytoin * diazepam * imipramine * lithium (your lithium blood level should be monitored if you are starting, changing dose, or stopping valdecoxib while taking lithium).

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 405: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexValdecoxib may also increase the blood levels of hormones (oestrogens and progestogens) contained in combined oral contraceptive pills, and this may increase the risk of side effects from these pills. Discuss this with your doctor.Other NSAIDs can reduce the removal of the medicine methotrexate from the body. This has not been reported with valdecoxib, but people taking methotrexate should be well monitored for any side effects of methotrexate while taking valdecoxib.Preg: CNama Dagang: Bextra

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 406: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexEtoricoxibNSAIDI: Acute gout, RA, OABSO: Tab salut selaput 60 mg, 90 mg, 120 mg

D: 60 -120 mg 1x/hrKI: < 16 years of age, allergic reactions, Severely decreased liver function, Moderate to severely decreased kidney function, Active peptic ulcer or bleeding from the gut, Inflammatory bowel disease such as Crohn's disease or ulcerative colitis, hypertension, Heart failure, ischaemic heart disease, cerebrovascular disease, peripheral arterial disease, Pregnancy, Breastfeeding, Rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malsorption (Arcoxia tablets contain lactose).P: Elderly people, History of disorders affecting the stomach or intestines, such as ulceration or bleeding, Decreased liver & kidney function, Liver cirrhosis, Dehydration, History of heart

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 407: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexfailure, oedema, hypertension, hyperlipidaemia, Diabetes, SmokersES: Headache, Dizziness, diarrhoea, constipation, nausea, vomiting, indigestion, flatulence or abdominal pain, oedema, hypertension, asthenia, Fatigue, Cold or flu-like symptoms, Skin reactions such as rash and itch, Blurred vision, insomnia, Muscle cramps, Weight gain, Anxiety, Depression, epistaxis, dyspnoea, Chest pain, Heart attack or stroke, Ulceration or bleeding of the stomach or intestine, Liver or kidney disordersIO: Preg:: A, B, C, D, X Nama Dagang: Arcoxia

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 408: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexEtanerceptSoluble p75 TNF receptor fusion protein (sTNFR-Ig). Inhibits TNF binding to cell surface receptors, which, in turn, decreases inflammatory and immune responses.BSO: Vial 25 mgD: 25 mg SC 2x/wk with or without concomitant administration of MTXKI: Hipersensitif, sepsis, concurrent live vaccinationIO: -Preg: B P:Caution in impaired renal function and asthma; discontinue administration if serious infection develops; adverse effects may include injection site pain, localized erythema, rash, URI symptomology, GI upset, nausea, vomiting, rhinitis, cough, and drug-induced lupus Nama Dagang: Enbrel

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 409: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexParecoxibI: Terapi jangka pendek utk nyeri pasca operasiBSO: Vial 20 mgD: 40 mg IV/IM diikuti 20-40 mg 2-4x/hr. Max 80 mg/hrLansia > 65 th: BB < 50 Kg ½ dosis lazim. Max 40 mg/hr KI: Hipersensitif, hamil (tirm 1 & 2), laktasi, tukak peptic aktifP: ES: Hipoestesi, nyeri punggung, edema perifer, osteitis alveolar, dispepsia, kembung, peningkatan kreatinin, hipokalemia,agitasi, insomnia.IO: Warfarin, diuretik, antihipertensi, siklosporin, takrolimus, flukonazol, rifampisin, fenitoinPreg:: A, B, C, D, X Nama Dagang: Dynastat

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 410: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTinoridineI: Radang pasca bedah, cedera sal. Kemih, radang akut sal nafas atas, otitis, artritis, uretritis, epididimitis, lumbago, nyeri punggung, artralgia, nyeri setelah cabut gigi, rematikBSO: Kaps 50 mgD: 50-100 mg 2x/hrKI: P: ES: Jarang, ggn GI, vertigo, mulut keringIO: Preg:: A, B, C, D, X Nama Dagang: Nonflamin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 411: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSodium hyaluronate/ Hyaluronic acidI: Surgical aid in cataract extraction, intraocular implantation, corneal transplant, glaucoma filtration, and retinal attachment surgeryBSO: Jarum suntik 10 mg/mL, 12 mg/mL, 14 mg/mL, 16 mg/mL 20 mg/cc, 30 mg/mLD: 3 cc/ sendi lutut atau pinggang sebagai dosis tunggalKI: Hypersensitivity to hyaluronateP: Do not overfill the anterior chamber; carefully monitor intraocular pressure; risk of hypersensitivity existsES: 1% to 10%: Ocular: Postoperative inflammatory reactions (iritis, hypopyon), corneal edema, corneal decompensation, transient postoperative increase in IOPIO: Preg: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 412: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNimesulideI: OA, RA, pnykit Rematik ekstra artikuler, nyeri & peradangan sesudah intervensi bedah & akibat trauma akut, dismenore.BSO: Tab 100 mg

D: 100 mg 2x/hrKI: Hipersensitifitas, tukak lambung, Anak, HamilP: Ggn fungsi ginjal dan jantungES: Anoreksia, urin gelap,perforasi, vertigo.IO: AINS lain: meningkatkan resiko perdarahanPreg: X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 413: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexInfliximabChimeric IgG1k monoclonal antibody that neutralizes cytokine TNF-alpha and inhibits its binding to TNF-alpha receptor. Reduces infiltration of inflammatory cells and TNF-alpha production in inflamed areas. Used with MTX in patients who have inadequate response to MTX monotherapy.BSO: Vial 100 mgD: 3 mg/kg IV at weeks 0, 2, and 6; then q4-8wk, usually with MTX; some patients require higher doses (4-5 mg/kg)KI: HipersensitifPreg: BP: TNF-alpha modulates cellular immune responses; anti–TNF therapies, such as infliximab, may adversely affect normal immune responses and allow development of superinfections; may increase risk of reactivation of TB in patients with certain granulomatous infections; PPD-+ patients require TB prophylaxis; may cause anti-DNA antibodies and drug-induced lupus Nama Dagang: Remicade

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 414: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexRituximabChimeric IgG1-kappa monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The Fab domain of rituximab binds to CD20 antigen on B lymphocytes, and Fc domain recruits immune effector functions to mediate B-cell lysis in vitro. Possible mechanisms of cell lysis include complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC). Rituximab in combination with methotrexate is indicated to reduce signs and symptoms in adult patients with moderately to severely active RA who have had an inadequate response to one or more TNF antagonist therapies.BSO: Injection, preservative free: 100 mg/ 10cc; 500 mg/50ccD: Give two 1-g IV infusions 2 wk apartGlucocorticoids administered as methylprednisolone 100 mg IV or equivalent 30 min prior to each infusion are recommended to reduce incidence and severity of infusion reactions

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 415: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAdults: I.V. (refer to individual protocols): Do not administer I.V. push or bolus (hypersensitivity reactions may occur). Consider premedication (consisting of acetaminophen and diphenhydramine) before each infusion of rituximab. Premedication may attenuate infusion-related events. Because transient hypotension may occur during infusion, give consideration to withholding antihypertensive medications 12 hours prior to rituximab infusion.KI: Known anaphylaxis or IgE-mediated hypersensitivity to murine proteins or any component of productIO: renal toxicity reported with drug in combination with cisplatin in clinical trials (in clinical trials involving patients with RA, concomitant administration of MTX or cyclophosphamide did not alter pharmacokinetics of rituximab)Preg: CP: Safety and efficacy of re-treatment not established in controlled trials; not recommended in patients with RA and no prior inadequate response to one or more TNF antagonists; has caused severe infusion reactions (in some cases, reactions

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 416: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexwere fatal); hepatitis B virus (HBV) reactivation with fulminant hepatitis, hepatic failure, and death has been reported in some patients with hematologic malignancies treated with rituximab; hypersensitivity reactions (non–IgE-mediated reactions reported); mucocutaneous reactions, some with fatal outcome, have been reported in patients treated with rituximab; vaccination with live-virus vaccines not recommendedNama Dagang: MabThera

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 417: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexGlucosamine HCl, Chondroitin sulphate I: OA, membantu melindungi kerusakan rawan sendiBSO: Krim

D: 2-3x/hrKI: P: ES: IO: Preg:: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FaiK Fauzi MuLaCheLLa

faik-mulachella.blogspot.comfaikshare.blogspot.com

em@il: [email protected]

Blog:

Page 418: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDiacereinI: Terapi oral jangka panjang spesifik utk penykt sendi degeneratif (OA & penyakit lain yg berkaitan) BSO: Kapl 50 mg

D: 1 kapl 2x/hrKI: HipersensitifP: Hamil & laktasiES: Mual, muntah, diare, nyeri epigastrikIO: Obat yg menyebabkan perubahan transit intestinal & atau kualitas kandungan intestinal (misalnya kelebihan serat atau filtrate), Al hidroksida, Mg hidroksidaPreg: BNama Dagang: Artrodar

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 419: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLeflunomideAntimetaboliteFirst new DMARD approved in more than 10 years. Blocks autoimmune antibodies and reduces inflammation. Inhibits dihydroorotate dehydrogenase, an enzyme in the de novo pyrimidine synthesis pathway. Studies indicate that it reduces symptoms, possibly better than MTX, and may even slow progression of RA. Use with caution in renal insufficiencyI: Treatment of active rheumatoid arthritis to reduce signs and symptoms and to retard structural damage as evidenced by x-ray erosions and joint space narrowingBSO: Tablet: 10 mg, 20 mg, 100 mgD: Initial: 100 mg/d PO for 3 dMaintenance dose: 10-20 mg/d POKI: HipersensitifIO: Cholestyramine and charcoal reduce effects; concomitant rifampin increases toxicityPreg: XP:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 420: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSerious adverse reactions include hepatotoxicity and immunosuppression; other reactions include nausea, diarrhea, abdominal pain, rash, bronchitis, headache, hypertension, dizziness, and alopecia; caution if impaired liver or renal function or if immunodeficient; leflunomide is a prodrug and active metabolite has a very long plasma half-life (approximately 15 d); with serious toxicity, can be cleared more quickly using cholestyramine 8 mg tid.Nama Dagang:Arava

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 421: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexC. Preparat GoutColchicineAllopurinol IndometacinPhenylbutazoneProbenecid

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 422: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexColchicine-- Inhibits microtubules and thereby may inhibit phagocytosis, neutrophil mobility, and chemotaxis. Also may inhibit generation of prostaglandins.BSO: Injection: 0.5 mg/mLTablet: 0.5 mg, 0.6 mg D: PO for acute flares: 0.5 mg or 0.6 mg q1h until significant pain relief, adverse GI effects, or a total dose of 6 mgIV acute flares: 1 mg in 20 mL of isotonic sodium chloride solution without glucose pushed through a secure IV line over 10-20 minCan be repeated in 6 h, but no more than 4 mg in 24 h and no further colchicine by any route for a weekProphylaxis: 0.5 mg or 0.6 mg bid PO; adjust dose for renal insufficiencyKI: Hipersensitif; severe renal, hepatic, GI, or cardiac disorders; blood dyscrasiasIO:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 423: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSympathomimetic agent toxicity and effect of CNS depressants are significantly increasedPreg: XP:Risk of renal failure, hepatic failure, permanent hair loss, bone marrow suppression, numbness or tingling in hands and feet, disseminated intravascular coagulopathy, and decreased sperm count; dose-dependent GI upset is common; rarely myopathy and neuropathy, especially with long-term treatment in the setting of renal insufficiency Nama Dagang:Recolfar

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 424: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAllopurinol-- Reduces production of uric acid, thereby allowing body to dispose of excess uric acid stores. Most effective therapy to lower serum uric acid. Most patients achieve the target uric acid level of 5 mg/dL at 300-400 mg/d, less if renal insufficiency is present.I: HiperurikemiaBSO: Injection: 500 mg Tablet: 100 mg, 300 mg D:Initial: 100 mg/d PO; titrate monthly according to serum uric acid levelMaintenance: 300-400 mg/d POEffective doses based on GFR: 400 mg PO qd for 140 mL/min creatinine clearance; 300 mg for 100 mL/min creatinine clearance; 200 mg for 60 mL/min creatinine clearance; 150 mg for 40 mL/min creatinine clearance; 100 mg for 20 mL/min or lessKI:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 425: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexHipersensitif (if reaction not severe, can try a desensitization regimen [Fam, 2001] [Walz-LeBlanc, 1991])IO:Alcohol decreases effects; increases incidence of skin rash when used concurrently with ampicillin and amoxicillin; large amounts of vitamin C acidifies urine and may cause renal stone formation; inhibits metabolism of azathioprine and 6-mercaptopurinePreg: CP:Not for use in asymptomatic hyperuricemia; reduce dose in renal insufficiency; monitor liver function and perform CBC count before initiating therapy and periodically thereafter, discontinue medication if rash occurs and evaluate Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 426: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexProbenecid-- Designed to lower tissue stores of uric acid by increasing net renal excretion of uric acid by inhibiting tubular reabsorption. D: 250 mg PO bid for 1 wk, then 500 mg bid; can increase up to 3 g/dKI: Hipersensitif; children <2 y; high urinary uric acid excretion, renal insufficiency (GFR <50 mL/min), renal stones; known blood dyscrasia; coadministration of ketorolac because levels/toxicity of ketorolac are significantly increasedIO: Salicylates at high dosages and nitrofurantoin may decrease effects; increases levels/toxicity of methotrexate, beta-lactam antibiotics, acyclovir, thiopental, clofibrate, dyphylline, pantothenic acid, ketorolac, benzodiazepines, rifampin, sulfonamide, dapsone, zidovudine, and sulfonylureasPreg: BP: crosses placental barrier; use of any drug in women of childbearing potential requires anticipated benefit be weighed against possible hazards; caution in history of peptic ulcer; can provoke attacks of acute gouty arthritis and renal stones

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 427: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexD. Anti Konvulsan & Anti epilepsyDiazepamClonazepamPhenobarbitalCarbamazepineOxcarbazepinePhenytoin GabapentinValproic acidLamotrigineLevetiracetamTopiramateMagnesium sulphate

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 428: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDiazepam-- Effective in treating vertigo. Depresses all levels of CNS, including limbic and reticular formation, possibly by increasing activity of GABA, major inhibitory neurotransmitter. Individualize dosage and cautiously increase to avoid adverse effects. Effective for acute episodes. Discontinue as quickly as possible to maximize cerebellar vestibular compensation process.BSO: Gel, rectal delivery system: Pediatric rectal tip (4.4 cm): 5 mg/mL Adult rectal tip (6 cm): 5 mg/mL Injection: 5 mg/mL Injection, emulsified: 5 mg/mL Solution, oral (wintergreen-spice flavor): 5 mg/5 mL Solution, oral concentrate: 5 mg/mL Tablet: 2 mg, 5 mg, 10 mg D: 5-10 mg PO/IV/IM q4-6h Paed. <6 months: Not recommended>6 months:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 429: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index0.05-0.3 mg/kg/dose IV/IM over 2-3 min, repeat in 2-4 h prn0.12-0.8 mg/kg/d PO divided q6-8h; max 10 mg/dose KI: Hipersensitif IO: Increases toxicity of benzodiazepines in CNS with coadministration of phenothiazines, barbiturates, alcohols, and monoamine oxidase inhibitor (MAOIs) Preg: DP:Caution with other CNS depressants, low albumin levels, or hepatic disease (may increase toxicity) Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 430: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexClonazepam-- Suppresses muscle contractions by facilitating neurotransmission of GABA and other inhibitory transmitters.BSO: Tablet: 0.5 mg, 1 mg, 2 mgD: Based on equivalent doses of other benzodiazepines (eg, 1 mg PO of clonazepam for 1-2 mg of alprazolam)KI: Hipersensitif; severe liver disease; acute narrow-angle glaucomaIO: Phenytoin and barbiturates may reduce effects; coadministration of CNS depressants increase toxicityPreg: DP: Caution in chronic respiratory disease or impaired renal function; withdrawal symptoms can result from abrupt discontinuation of the medication Other P: include history of drug and alcohol abuse; monitor blood counts and liver function tests Nama Dagang:Rivotril

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 431: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPhenobarbital-- Best studied barbiturate in treatment of SE. Can be administered 20 mg/min IV. If patient has received benzodiazepine, potential for respiratory suppression significantly increased.I: Management of generalized tonic-clonic (grand mal) and partial seizures; sedativeBSO: Capsule: 16 mg Elixir: 15 mg/5 mL; 20 mg/5 mL Injection: 30 mg/mL; 60 mg/mL; 65 mg/mL; 130 mg/mL Powder for injection: 120 mg Tab: 8mg, 15mg, 16mg, 30 mg, 32 mg, 60 mg, 65 mg, 100 mg D: Children: Sedation: Oral: 2 mg/kg 3x/day Hypnotic: I.M., I.V., S.C.: 3-5 mg/kg at bedtime Preoperative: Oral, I.M., I.V.: 1-3 mg/kg 1-1.5 hours pre-op Adults: Sedation: Oral, I.M.: 30-120 mg/day in 2-3 divided doses Hypnotic: Oral, I.M., I.V., S.C.: 100-320 mg at bedtime Preoperative: I.M.: 100-200 mg 1-1.5 hours pre-op

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 432: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAnticonvulsant: Status epilepticus: Loading dose: I.V.: Infants and Children: 10-20 mg/kg 1-2x/day; in select patients may administer additional 5 mg/kg/dose every 15-30 minutes until seizure is controlled or a total dose of 40 mg/kg is reached Adults: 1st 300-800 mg, then 120-240 mg/dose at 20-minute intervals until seizures are controlled or a total dose of 1-2 g Anticonvulsant maintenance dose: Oral, I.V.: Infants: 5-8 mg/kg/day in 1-2 divided doses Children: 1-5 years: 6-8 mg/kg/day in 1-2 divided doses 5-12 years: 4-6 mg/kg/day in 1-2 divided doses Children >12 years and Adults: 1-3 mg/kg/day in divided doses or 50-100 mg 2-3 times/day Withdrawal: Initial daily requirement is determined by substituting phenobarbital 30 mg for every 100 mg pentobarbital used during tolerance testing; then daily requirement is decreased by 10% of initial dose Dosing interval in renal impairment: Clcr <10 mL/minute: Administer every 12-16 hours

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 433: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexHemodialysis: Moderately dialyzable (20% to 50%) Dosing adjustment/comments in hepatic disease: Increased side effects may occur in severe liver disease; monitor plasma levels and adjust dose accordingly 20 mg/kg IV q20min until seizures controlled or total 1-2 g administeredPaed.20 mg/kg IV over 10-15 min in single or divided dose until seizure controlled or 40 mg/kg administeredKI: HipersensitifIO: Combination with benzodiazepines causes significant respiratory depression; strongly consider elective intubation before combination givenPreg: BP: -Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 434: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCarbamazepineEffective in patients who have not responded to lithium therapy. Also can act to inhibit seizures induced through the kindling effect, which is thought to occur by way of repeated limbic stimulation. Has been effective in treating patients who have rapid-cycling bipolar disorder or those who have not been responsive to lithium therapy.BSO: Capsule, extended release: 200 mg, 300 mg Suspension, oral: 100 mg/5 mL Tablet: 200 mg Tablet, chewable: 100 mg Tablet, extended release: 100 mg, 200 mg, 400 mg D: 1st 200 mg PO qd in divided doses with increments of 100 mg 2 times/wk; if adverse effects occur, decrease 200 mgDose range: 300-1600 mg PO qdSerum level range: 17-50 mmol/L (4-12 mcg/mL)Manic episode: 200-1800 mg PO qdPlasma level: 4-12 mcg/mLPaed.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 435: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index6-12 years: 100 mg PO bid or 10 mg/kg/d divided bid initially, then increase to 100 mg/d every wkMaintenance: 20-30 mg/kg/d PO bid/qid; max 1 g/dKI:Hipersensitif; administration of MAOIs within last 14 d; history of liver disease, cardiovascular disease, and blood dyscrasiasIO:Halothane coadministration may cause hepatocellular damage; grapefruit juice, influenza vaccine, isoniazid, cimetidine, erythromycin, and phenelzine increase plasma levels; phenytoin, alprazolam, clonazepam, primidone, and phenobarbital decrease both CBZ level and levels of interacting agents; fluoxetine increases level; decreases levels of imipramine, phenothiazines, haloperidol, theophylline, thyroid hormones, ritonavir, saquinavir, contraceptives, risperidone, thiothixene, cyclosporine, corticosteroids, doxycycline, trazodone, doxepin, and amitriptyline; increases plasma levels of diltiazem and verapamil; can reduce its own level by "autoinduction;" coadministration with lithium or loxapine

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 436: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexincreases toxicity of both CBZ and the interacting agents; coadministration with clozapine further increases bone marrow toxicity and resulting agranulocytosisPreg: DP:A very small, but significant, risk of causing agranulocytosis or aplastic anemia exists.During drug initiation, avoid using hazardous equipment or driving; other depressants and alcohol may lead to increased dizziness and sleepiness; keep in a dry place; drinking grapefruit juice while taking CBZ elevates blood levels; report any indications of blood dyscrasias (eg, easy bruising, sore throats, fever, rash)Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 437: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexOxcarbazepineI: Epilepsy to control partial seizures. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it .BSO: Tablet: 150 mg, 300 mg, 600 mgD: Adults > 17 —At first, 300 mg 2x/d.max 2.4 g a day.Children 2-16—8-10 mg/kg/day, divided into 2 doses. KI: Allergy, children < 6 yearsP: Elderly people, Decreased kidney & liver function, heart block, Heart failure, arrhythmias, hyponatraemia, porphyrias.ES: Somnolence, Headache, Dizziness, Visual disturbances, Fatigue, diarrhoea, constipation, nausea, vomiting or abdominal pain, hyponatraemia, Agitation, Confusion, Depression, emotional lability, ataxia, Concentration or memory difficulties, Skin reactions such as rash and itch, Acne, alopecia, asthenia, leucopenia, hepatitis, Irregular heart beats, SLE.Preg: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 438: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPhenytoin -- Mainstay in treatment of SE. Must be administered slowly and therefore takes longer to enter brain than benzodiazepines. Has advantage of being long-term anticonvulsant and can be administered PO after acute illness. Not water soluble, and must be solubilized in propylene glycol carrier with pH 12 to prepare IV form; therefore, cannot be given >50 mg/min without risk of significant hypotension and cardiac arrhythmias. Also major risk of potential irritation at IV site and vascular compromise of infused limb. Therefore, use in SE should be avoided if possible.BSO: Capsule: Extended: 30 mg, 100 mg Prompt: 100 mg Injection: 50 mg/mL Suspension, oral: 30 mg/5 mL; 125 mg/5 mL Tablet, chewable: 50 mg D:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 439: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index15-20 mg/kg IV, max 50 mg/min; intubate if necessary and control hyperthermia; if seizures continue after 20 min, give additional 10 mg/kg; target levels after correction of hypoalbuminemia should be 20-30 mcg/mL in SEKI: HipersensitifIO: None reported as contraindicated for this indicationPreg: CP: Risk of hypotension and cardiac arrhythmias (perform cardiac monitoring during infusion); infusion rate should be <50 mg/min Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 440: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexGabapentinI: Epilepsy - used for partial seizures with or without secondary generalisation. This medicine may be used on its own to treat adults and children aged 12 years and over, or as an add-on therapy for adults and children aged six years and over who are already taking other antiepileptics.# Nerve pain (neuropathic pain) in adults, for example due to diabetic neuropathy or following shingles (post-herpetic neuralgia).# Trigeminal neuralgia, which is severe pain in the lips, gums, cheek, chin or eye caused by a disorder of the nerves in the face (unlicensed use)BSO: Capsule: 100 mg, 300 mg, 400 mg, 600 mg, 800 mgD: If gabapentin is discontinued or if another anticonvulsant is added to therapy, it should be done slowly over a minimum of 1 week Initial: 300 mg 3 times/day, if necessary the dose may be increased using 300 or 400 mg capsules 3 times/day up to 1800 mg/day

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 441: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTotal daily dosage range: 900-1800 mg/day administered in 3 divided doses at 8-hour intervals Pain: 300-1800 mg/day given in 3 divided doses has been the most common dosage range Bipolar disorder: 300-3000 mg/day given in 3 divided doses Dosing adjustment in renal impairment:Clcr >60 mL/minute: Administer 1200 mg/day Clcr 30-60 mL/minute: Administer 600 mg/day Clcr 15-30 mL/minute: Administer 300 mg/day Clcr <15 mL/minute: Administer 150 mg/day Hemodialysis: 200-300 mg after each 4-hour dialysis following a loading dose of 300-400 mg KI: Allergy# Neurontin capsules contain lactose and should not be taken by people with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption. Neurontin tablets do not contain lactose.P: Elderly people, Decreased kidney function, Diabetes.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 442: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexES: Dizziness, somnolence, ataxia, indigestion, nausea, vomiting, constipation, diarrhoea or abdominal pain, Changes in appetite, Weight gain, oedema, rash or itching, purpura, Visual disturbances, paraesthesia, Tremor or twitching, insomnia, Headache, Anxiety or nervousness, emotional lability, amnesia, Depression, leucopenia, Impotence, Incontinence.IO: Gabapentin does not modify plasma concentrations of standard anticonvulsant medications (ie, valproic acid, carbamazepine, phenytoin, or phenobarbital) Antacids reduce the bioavailability of gabapentin by 20% Cimetidine may decrease clearance (by 14%) of gabapentin; gabapentin may increase Cmax of norethindrone by 13% Preg: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 443: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexValproic acid/ Valproate sodium Has proven effectiveness in treating and preventing mania. Classified as a mood stabilizer and can be used alone or in combination with lithium. Useful in treating patients with rapid-cycling bipolar disorders and has been used to treat aggressive or behavioral disorders. A combination of valproic acid and valproate has been effective in treating persons in manic phase, with a success rate of 49%.BSO: Capsule, sprinkle,: 125 mg Injection,: 100 mg/mL Syrup: 250 mg/5 mL Tablet, delayed release,: 125 mg, 250 mg, 500 mg D:250 mg PO tid, initially in increments until a serum level of 350-700 mmol/L (50-100 mcg/mL) has been achievedMaintenance: 750-3000 mg PO qd in divided dosesManic episode: Loading dose of 20 mg/kg/d POStat dose: 20 mg/kg PO, with next dose in 12 h; then 10 mg/kg bid

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 444: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMaintenance: 500-3500 mg PO qd to achieve plasma level of 50-125 mcg/mLPaed. 10-15 mg/kg/d PO initially in 1-3 divided doses; increase by 5-10 mg/kg/d PO qwk until therapeutic plasma level achieved. Maintenance: 30-60 mg/kg/d PO divided bid/tidKI: Hipersensitif, hepatic disease/dysfunctionIO: Coadministration with cimetidine, salicylates, felbamate, and erythromycin may increase toxicity; rifampin may significantly reduce valproate levels; in pediatric patients, protein binding and metabolism of valproate decrease when taken concomitantly with salicylates; coadministration with carbamazepine may result in variable changes of carbamazepine concentrations, with possible loss of seizure control; valproate may increase diazepam and ethosuximide toxicity (monitor closely); valproate may increase phenobarbital and phenytoin levels, while either one may decrease valproate levels; valproate may displace warfarin from protein binding sites (monitor coagulation tests); may increase zidovudine levels in patient sero+ for HIV; valproate inhibits the metabolism

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 445: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexof lamotrigine and increases the risk of Stevens-Johnson syndrome (a lamotrigine dose has to be titrated up more slowly when used with valproate)Preg: DP: Monitor for hepatic toxicity (obtain liver function tests prior to initiating therapy and thereafter); serum ammonia levels may increase independently of other liver functions and may cause altered mental status; check platelet count and bleeding times prior to therapy and during treatment; valproic acid inhibits cytochrome P-450 metabolism system (pay attention to any drugs that use this system); monitor for symptoms of pancreatitis and pancreatic enzymes because hemorrhagic pancreatitis has been reported Nama Dagang: Depakene

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 446: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexValproate semisodiumNama Dagang:depakote

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 447: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLamotrigineAnticonvulsant that appears to be effective in the treatment of the depressed-phase in bipolar disorders.BSO: Tablet: 50 mg, 100 mgD:12.5-37.5 mg/d PO, initially, gradually titrated in 25-mg increments not more often than weekly; effective dose usually 100-400 mg/d qd or divided bidPaed. 2-15 mg/kg/d PO divided bid initiallyKI:Hipersensitif; lactation; renal impairment; hepatic and cardiac problemsIO:Acetaminophen increases renal clearance and decreases effects; similarly, phenobarbital and phenytoin increase metabolism, causing a decrease in levels; concurrent administration with valproic acid increases lamotrigine levelsPreg: CP:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 448: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCan cause adverse CNS effects, including dizziness, sedation, ataxia, nystagmus, and diplopia; dermatological problems include hypersensitivity rash, Stevens-Johnson syndrome, and angioedema; renal involvement can produce hematuria; caution in impaired renal or hepatic function; fatal hypersensitivity reactions to lamotrigine are more likely to occur with rapid dose increments (caution when coadministered with valproate) Nama Dagang: Lamictal

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 449: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLevetiracetamI: Indicated as adjunctive therapy in the treatment of partial onset seizures in adults with epilepsyBSO: Tab 250 mg, 500 mg, 750 mgD: Adults: Initial: 500 mg 2x daily; additional dosing increments may be given (1 g/day additional q2wk). max 3 g Dosing adjustment in renal impairment:Clcr 50-80 mL/min: 500-1000 mg every 12 hours Clcr 30-50 mL/min: 250-750 mg every 12 hours KI: Children < 4 years of age.P: Decreased kidney & liver function.ES: Dizziness or loss of balance, somnolence, Headache, asthenia, emotional lability, Hostility, Nervousness, Loss of appetite, amnesia, ataxia, Hyperactivity, Shaking, tremor, insomnia, Depression, Personality disorders, Abnormal thinking or behaviour, diarrhoea, nausea, indigestion, Double vision, Rash, Hair loss.Preg: CNama Dagang:Keppra

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 450: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTopiramateAnticonvulsant, MiscellaneousI: Adjunctive therapy for partial onset seizures in adults and pediatric patients (ages 2-16 years) Orphan drug: Topiramate has also been granted orphan drug status for the treatment of Lennox-Gastaut syndrome BSO: Capsule: 15 mg, 25 mg Tablet: 25 mg, 100 mg, 200 mg D: Seizures: Adults—25-50 mg/hari for first week. Max 400 mg/day.Children (2-16): 25 mg nightly for 1wk. increase q1 or 2 weeks, 2x/hari.Prevent seizures:50 mg/day 2x/day for 1wk. Max. 400 mg/day 2x/day. Prevent migraine headaches:Adults—25 mg/day for 1wk. Max. 100 mg/day.KI: Epilepsy in children < 2 years of age, Migraine in children < 16 years of age, Breastfeeding, Rare hereditary problems of

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 451: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexgalactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.P: Decreased liver & kidney function, history of kidney stones, hypercalciuria, History of depression or suicidal thoughts, Adolescents and young adults, Severe lung/breathing disorders, Hereditary blood disorders called porphyrias.ES: Paraesthesia, Headache, Fatigue, Dizziness, Drowsiness, Decreased appetite and weight loss, Nausea, insomnia, Depression, Concentration or memory difficulties, Abdominal pain, Nervousness, Decreased sense of touch, Confusion, Agitation, Visual disturbances.# Speech disturbances, ataxia, asthenia, Alteration in taste, Behaviour problems in children, metabolic acidosis.IO: CYP2C19 enzyme substrate; CYP2C19 enzyme inhibitor Digoxin levels and ethinyl estradiol blood levels are decreased when coadministered with topiramate Concomitant administration with other CNS depressants will increase its sedative effects; coadministration with other

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 452: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexcarbonic anhydrase inhibitors may increase the chance of nephrolithiasis Topiramate may increase phenytoin concentration by 25% Topiramate may decrease valproic acid concentration by 11% Preg: CNama Dagang: Topamax

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 453: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMagnesium sulphateMagnesium has been demonstrated to be superior to phenytoin for preventing and treating eclamptic seizures.BSO: Granules: ~40 mEq magnesium/5 g Injection: 100 mg/mL; 125 mg/mL; 250 mg/mL; 500 mg/mL Solution, oral: 50% [500 mg/mL] D:The recommended dietary allowance (RDA) of magnesium is 4.5 mg/kg which is a total daily allowance of 350-400 mg for adult men and 280-300 mg for adult women. During pregnancy the RDA is 300 mg and during lactation the RDA is 355 mg. Average daily intakes of dietary magnesium have declined in recent years due to processing of food. The latest estimate of the average American dietary intake was 349 mg/day. Dose represented as MgSO4 unless stated otherwise. Hypomagnesemia: Neonates: I.V.: 25-50 mg/kg/dose (0.2-0.4 mEq/kg/dose) every 8-12 hours for 2-3 doses

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 454: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexChildren: I.M., I.V.: 25-50 mg/kg/dose (0.2-0.4 mEq/kg/dose) every 4-6 hours for 3-4 doses, maximum single dose: 2000 mg (16 mEq), may repeat if hypomagnesemia persists (higher dosage up to 100 mg/kg/dose MgSO4 I.V. has been used); maintenance: I.V.: 30-60 mg/kg/day (0.25-0.5 mEq/kg/day) Adults: Oral: 3 g every 6 hours for 4 doses as needed I.M., I.V.: 1 g every 6 hours for 4 doses; for severe hypomagnesemia: 8-12 g MgSO4/day in divided doses has been used Management of seizures and hypertension: Children: I.M., I.V.: 20-100 mg/kg/dose every 4-6 hours as needed; in severe cases doses as high as 200 mg/kg/dose have been used Eclampsia, pre-eclampsia: Adults: I.M.: 1-4 g every 4 hours I.V.: Initial: 4 g, then switch to I.M. or 1-4 g/hour by continuous infusion Maximum dose should not exceed 30-40 g/day; maximum rate of infusion: 1-2 g/hour

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 455: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMaintenance electrolyte requirements: Daily requirements: 0.2-0.5 mEq/kg/24 hours or 3-10 mEq/1000 kcal/24 hours Maximum: 8-16 mEq/24 hours Cathartic: Oral: Children: 0.25 g/kg every 4-6 hours Adults: 10-15 g in a glass of water Dosing adjustment/comments in renal impairment: Clcr <25 mL/minute: Do not administer or monitor serum magnesium levels carefully Paed.20-100 mg/kg/dose IV q4-6h prn; in severe cases, may use doses as high as 200 mg/kg/dose IVKI: Hipersensitif; heart block, myocardial damage; Addison disease; severe hepatitisIO: Concurrent use of magnesium sulfate with nifedipine may cause hypotension and neuromuscular blockade; may increase neuromuscular blockade observed with aminoglycosides and potentiate neuromuscular blockade produced by tubocurarine,

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 456: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexvecuronium, and succinylcholine; may increase CNS effects and toxicity of CNS depressants, betamethasone, and cardiotoxicity of ritodrinePreg: AP: Levels of 8-12 mg/dL may cause loss of reflexes, diplopia, flushing, or slurring of speech; levels >12 mg/dL may cause muscular paralysis, ventilatory failure, and circulatory collapse; patients should have frequent neurological evaluations; loss of deep tendon reflex indicates that the magnesium level may be toxic; some clinicians follow serum magnesium levels q6h along with neurological examination; magnesium may alter cardiac conduction, leading to heart block in digitalized patients; in overdose, calcium gluconate 10-20 mL IV of 10% solution can be administered as antidote for clinically significant hypermagnesemia Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 457: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexE. Minor Transquilizer, Anxietas & RelaxanDiazepamMidazolam

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 458: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMidazolam-- Onset of action 35 s after IV injection and is well absorbed when injected IM. Duration of action is 15 min, and elimination half-life is 2-5 h. No active metabolites exist and have greater affinity for benzodiazepine receptors than diazepam.D: 0.01-0.05 mg/kg IV over 2 min; may repeat q15min; max 10 mg. Paed. 0.05-0.2 mg/kg IV over 2-3 minKI: Hipersensitif; preexisting hypotension; narrow-angle glaucoma; sensitivity to propylene glycol (the diluent)IO: Metabolism of midazolam may be reduced in the presence of medications that share same metabolic pathway; sedative effects of midazolam may be antagonized by theophyllines; narcotics and erythromycin may accentuate sedative effects of midazolam because of decreased clearancePreg: DP: Caution in congestive heart failure, pulmonary disease, renal impairment, and hepatic failureNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 459: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexF. Major TransquilizerChlorpromazinePerphenazineTrifluoperazineHaloperidolSulpirideProchlorpherazineOlanzapine

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 460: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexChlorpromazineMechanisms responsible for relieving nausea and vomiting include blocking postsynaptic mesolimbic dopamine receptors, anticholinergic effects, and depression of RAS. Blocks alpha-adrenergic receptors and depresses release of hypophyseal and hypothalamic hormones.BSO: Capsule, sustained action: 30 mg, 75 mg, 150 mg, 200 mg, 300 mg Concentrate, oral: 30 mg/mL; 100 mg/mL Injection: 25 mg/mL Suppository, rectal: 25 mg, 100 mg Syrup: 10 mg/5 mL Tablet: 10 mg, 25 mg, 50 mg, 100 mg, 200 mg D: Children >6 months: Psychosis: Oral: 0.5-1 mg/kg/dose q4-6 hours; I.M., I.V.: 0.5-1 mg/kg/dose q6-8 hours; max for <5 y: 40 mg/day; max for 5-12 years: 75 mg/day Nausea and vomiting: Oral: 0.5-1 mg/kg/dose q4-6 hours as needed

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 461: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIM/IV: 0.5-1 mg/kg/dose q6-8 hours; max for <5 y: 40 mg/day; max for 5-12 y: 75 mg/day Rectal: 1 mg/kg/dose q6-8 hours as needed Adults: Psychosis: Oral: Range: 30-2000 mg/day in 1-4 divided doses, initiate at lower doses and titrate as needed; usual dose: 400-600 mg/day; some patients may require 1-2 g/day I.M., I.V.: Initial: 25 mg, may repeat (25-50 mg) in 1-4 hours, gradually increase to a max. of 400 mg/dose q4-6 hours until patient is controlled; usual dose: 300-800 mg/day Intractable hiccups: Oral, I.M.: 25-50 mg 3-4 times/day Nausea and vomiting: Oral: 10-25 mg every 4-6 hours I.M., I.V.: 25-50 mg every 4-6 hours Rectal: 50-100 mg every 6-8 hours Elderly (nonpsychotic patient; dementia behavior): Initial: 10-25 mg 1-2 times/day; increase at 4- to 7-day intervals by 10-25 mg/day. Increase dose intervals (bid, tid, etc) as necessary to control behavior response or side effects; maximum daily dose:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 462: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index800 mg; gradual increases (titration) may prevent some side effects or decrease their severity. KI: Hipersensitif; bone marrow suppression, narrow-angle glaucoma, severe liver or cardiac diseaseIO: Other CNS depressants, anticholinergics, or anticonvulsants; antihypertensives may cause additive effect; coadministration with epinephrine may cause hypotensionPreg: CP: May cause pseudoparkinsonism; akathisia is a common extrapyramidal reaction in elderly patients; lowers seizure threshold and increases risk of seizures in patient with history of seizures Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 463: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPerphenazineI: Hypomania, Agitated and excited states, Anxiety (short term use), Mania, Nausea and vomiting, Persistant hiccups, Psychotic illness, Schizophrenia, Violent and dangerous behaviourBSO: Concentrate, oral: 16 mg/5 mL Injection: 5 mg/mL Tablet: 2 mg, 4 mg, 8 mg, 16 mg D: Psychoses: Oral: 1-6 years: 4-6 mg/day in divided doses 6-12 years: 6 mg/day in divided doses >12 years: 4-16 mg 2-4 times/day I.M.: 5 mg every 6 hours Nausea/vomiting: I.M.: 5 mg every 6 hours Adults: Psychoses: Oral: 4-16 mg 2-4 times/day max 64 mg/day I.M.: 5 mg every 6 hours up to 15 mg/day in ambulatory patients and 30 mg/day in hospitalized patients Nausea/vomiting:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 464: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexOral: 8-16 mg/day in divided doses up to 24 mg/day I.M.: 5-10 mg every 6 hours as necessary up to 15 mg/day in ambulatory patients and 30 mg/day in hospitalized patients I.V. (severe): 1 mg at 1- to 2-minute intervals max 5 mg Hemodialysis: Not dialyzable (0% to 5%) KI: Breastfeeding, Children < 14 years, policitemia, leucopeniaP: 'prolonged QT interval', myasthenia gravis, Agitation and restlessness, Alcohol withdrawal, Brain damage, Closed angle glaucoma, Coronary heart disease, cardiovascular disease, Elderly people, Epilepsy, Heart failure, Hypothyroidism, arrhythmias, Kidney failure, Liver disease, Parkinson's disease, brain damage, Pregnancy, Severe disease affecting the airways or lungs, phaeochromocytomaES: Dry mouth, postural hypotension, Blood disorders, Weight gain, convulsions, arrhythmias, urinary retention, extrapyramidal effects, tardive dyskinesia, Sexual problems, oculogyric crisis, Requires immediate treatment, DrowsinessPreg:CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 465: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTrifluoperazine I: Schizophrenia, Short-term treatment of severe anxiety, severely agitated behaviour and violent or dangerously impulsive behaviour, Nausea and vomiting.BSO: Concentrate, oral: 10 mg/mL Injection: 2 mg/mLTablet: 1 mg, 2 mg, 5 mg, 10 mg D: Children 6-12 years: Psychoses: Oral: Hospitalized or well supervised patients: Initial: 1 mg 1-2 times/day, gradually increase until symptoms are controlled or adverse effects become troublesome; maximum: 15 mg/day I.M.: 1 mg 2x/day Adults: Psychoses: Outpatients: Oral: 1-2 mg twice daily Hospitalized or well supervised patients: 1st : 2-5 mg 2x/day with optimum response in the 15-20 mg/day range; max 40 mg/day I.M.: 1-2 mg every 4-6 hours max 10 mg/24 hoursNonpsychotic anxiety: Oral: 1-2 mg 2x/day; max 6 mg/day; therapy for anxiety should not exceed 12 weeks; max 6 mg/day

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 466: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexfor longer than 12 weeks when treating anxiety; agitation, jitteriness, or insomnia may be confused with original neurotic or psychotic symptoms KI: Allergy, Disturbance in the normal numbers of blood cells in the blood, Heart failure, Liver disease, comatose states.P: Elderly people, Decreased kidney function, Heart disease, Angina pectoris, arrhythmias, Epilepsy, myasthenia gravis, Parkinson's disease, Closed angle glaucoma, prostatic hypertrophyES: Drowsiness, Dizziness, insomnia, Dry mouth, Constipation, Blurred vision, Muscle weakness, Loss of appetite, Skin rashes, Interference with the body's temperature regulation, Weight gain, Confusion, Abnormal movements of the hands, legs, face, neck and tongue, eg shakiness, twitching, rigidity, Anxiety, restlessness and agitation (akathisia), arrhythmias, jaundice, hyperprolactinaemia, Changes in menstrual periods, Disturbances in the normal numbers of blood cells in the blood.Preg: CNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 467: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexHaloperidol-- Controls psychosis and provides rapid tranquilization. Administer with a benzodiazepine to protect against lowered seizure threshold.BSO: Concentrate, oral: 2 mg/mL Injection: 50 mg/mL; 100 mg/mL Injection: 5 mg/mL Tablet: 0.5 mg, 1 mg, 2 mg, 5 mg, 10 mg, 20 mg D: Tab:Adults: 500 mcg-5 mg 2-3x/day. Max. 100 mg/day.Children 3-12= 15-40 kg: 25-150 mcg/kg/day, 2-3x/day.Children <3 Older adults: 500 mcg-2 mg 2-3x/day. For short-acting injection dosage form: Adults: 2-5 mg.For long-acting or depot injection dosage form: Adults: 10-15x dosis oral perhari, IM per bulan.KI: Hipersensitif; extrapyramidal symptoms; Parkinson diseaseIO:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 468: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSerum plasma levels decreased by rifampin; potentiates effects of CNS depressants (eg, alcohol, opiates, anesthetics); lithium has induced an encephalopathic syndromePreg: CP:Severe neurotoxicity manifesting as rigidity or inability to walk or talk may occur in patients with thyrotoxicosis also receiving antipsychotics; if administered IV/IM, watch for hypotension; caution in diagnosed CNS depression or cardiac disease; if history of seizures, benefits must outweigh risks; significant increase in body temperature may indicate intolerance to antipsychotics (discontinue if occurs)Ventricular arrhythmias such as torsade de pointes have been reported in patients, especially those with cardiac disease and in those given high doses of IV haloperidol Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 469: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSulpirideI: Schizophrenia, anti emetikBSO: Kaps 50 mg. Tab forte 200 mg. amp 100 mg/2ccD: KI: Children < 14 years, Severe liver & kidney disease, blood disorders, porphyries, phaeochromocytoma, pituitary prolactinoma, Breast cancer, Alcohol intoxication.# Reduced awareness, slow reactions or drowsiness due to illnesses that reduce activity in the central nervous system.P: Elderly people, Decreased kidney function, hypomania, History of epilepsy, Parkinson's disease, cardiovascular disease, 'prolonged QT interval', bradycardia, hypokalaemia, People at risk of stroke.ES: Restlessness and agitation, extrapyramidal effects, tardive dyskinesia, insomnia, Drowsiness, Dizziness, Weight gain, hyperprolactinaemia, Sexual problems, Convulsions, jaundice or hepatitis, arrhythmias.Preg:: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 470: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexProchlorpherazine-- Antidopaminergic drug that blocks postsynaptic mesolimbic dopamine receptors. Has anticholinergic effect and can depress reticular activating system. I : nausea and vomiting; psychosis; anxietyBSO : Capsule, sustained action: 10 mg, 15 mg, 30 mg Injection: 5 mg/mL Suppository, rectal: 2.5 mg, 5 mg, 25 mg Syrup: 5 mg/5 mL Tablet: 5 mg, 10 mg, 25 mg D: 5-10 mg PO/IM q6h25-mg supp PR q12h Paed.2.5 mg PO/PR q8h or 5 mg PO/PR q12h prn; max 15 mg/d0.1-0.15 mg/kg/dose IM; change to PO when possible KI:Hipersensitif; bone marrow suppression; narrow-angle glaucoma; severe liver or cardiac disease IO:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 471: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCoadministration with other CNS depressants or anticonvulsants may cause additive effects; administration with epinephrine may cause hypotension Preg: DP:Drug-induced Parkinson syndrome or pseudoparkinsonism frequent; akathisia most common extrapyramidal reaction in elderly; lowers seizure threshold; caution in history of seizures Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

FB: facebook.com/mulachella

Page 472: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexOlanzapine-- May inhibit serotonin, muscarinic, and dopamine effects. I: Manifestations of psychotic disorders; short-term treatment of acute manic episodes associated with bipolar I disorderBSO: Tablet: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg Tablet, orally-disintegrating: 5 mg, 10 mg, 15 mg, 20 mg D: Adults: 5-10 mg 1x/hr.; increase to 10 mg 1x/day within 5-7 days, thereafter adjust by 5 mg/day at 1-week intervals, max 20 mg/day; doses of 30-50 mg/day have been usedKI: HipersensitifIO: Fluvoxamine may increase effects; antihypertensives may increase risk of hypotension and orthostatic hypotension; levodopa, pergolide, bromocriptine, charcoal, carbamazepine, omeprazole, rifampin, and cigarette smoking may decrease effectsPreg: CP: Caution in narrow-angle glaucoma, cardiovascular disease, cerebrovascular disease, prostatic hypertrophy, seizure disorders, hypovolemia, and dehydration

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 473: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexG. Hipnotic & SedatifNitrazepamMidazolamEstazolamTriazolam

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 474: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNitrazepambenzodiazepinesI: InsomniaBSO: D: KI: Children, acute pulmonary insufficiency, myasthenia gravis, Phobias or obsessional states, Severe liver disease, respiratory depression, sleep apnoea syndrome, single medication for depression or chronic psychosisP: Breastfeeding, respiratory disease, Elderly people, History of alcoholism or drug abuse, Kidney disease, porphyries, Liver disease, Muscle weakness, Personality disorders, PregnancyES: Confusion, Addiction to the medicine, Muscle weakness, amnesia, Drowsiness and lightheadedness the next day, ataxiaIO: Preg:: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 475: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMidazolamBenzodiazepineI: Dental: Sedation component in I.V. conscious sedation in oral surgery patients; syrup formulation is used for children to help alleviate anxiety before a dental procedure Medical: Preoperative sedation and provides conscious sedation prior to diagnostic or radiographic procedures Unlabeled use: Anxiety, status epilepticus BSO: Injection: 1 mg/mL; 5 mg/mL Syrup: 2 mg/mLD: Personnel and equipment needed for standard respiratory resuscitation should be immediately available during midazolam administration.Infants <2 months and Children: Status epilepticus refractory to standard therapy: I.V.: Loading dose: 0.15 mg/kg followed by a continuous infusion of 1 mcg/kg/minute; titrate dose upward every 5 minutes until clinical seizure activity is controlled; mean infusion rate required in 24 children was 2.3 mcg/kg/minute with a range of 1-18 mcg/kg/minute

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 476: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexChildren: Preoperative sedation: I.M.: 0.07-0.08 mg/kg 30-60 minutes presurgery I.V.: 0.035 mg/kg/dose, repeat over several minutes as required to achieve the desired sedative effect max of 0.1-0.2 mg/kg Conscious sedation during mechanical ventilation: I.V.: Loading dose: 0.05-0.2 mg/kg then follow with initial continuous infusion: 1-2 mcg/kg/minute; titrate to the desired effect; usual range: 0.4-6 mcg/kg/minute Conscious sedation for procedures: Oral, Intranasal: 0.2-0.4 mg/kg (max 15 mg) 30-45’ pre-op I.V.: 0.05 mg/kg 3 minutes pre-op >12 years: I.V.: 0.5 mg q3-4’ until effect achieved Adults: Preoperative sedation: I.M.: 0.07-0.08 mg/kg 30-60 minutes presurgery; usual dose: 5 mg Conscious sedation: I.V.: Initial: 0.5-2 mg slow I.V. over at least 2 minutes; slowly titrate to effect by repeating doses every 2-3

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 477: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexminutes if needed; usual total dose: 2.5-5 mg; use decreased doses in elderly Healthy Adults <60 years: Some patients respond to doses as low as 1 mg; no more than 2.5 mg should be administered over a period of 2 minutes. Additional doses of midazolam may be administered after a 2-minute waiting period and evaluation of sedation after each dose increment. A total dose >5 mg is generally not needed. If narcotics or other CNS depressants are administered concomitantly, the midazolam dose should be reduced by 30%. Elderly: I.V.: Conscious sedation: Initial: 0.5 mg slow I.V.; give no more than 1.5 mg in a 2-minute period; if additional titration is needed, give no more than 1 mg over 2 minutes, waiting another 2 or more minutes to evaluate sedative effect; a total dose >3.5 mg is rarely necessary Sedation in mechanically intubated patients: I.V. continuous infusion: 100 mg in 250 mL D5W or NS, (if patient is fluid-restricted, may concentrate up to a maximum of 0.5 mg/mL); initial dose: 1 mg/hour; titrate to reach desired level of sedation

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 478: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexHemodialysis: Supplemental dose is not necessary Peritoneal dialysis: Significant drug removal is unlikely based on physiochemical characteristics KI: Hypersensitivity to this drug or any component of its formulation, including benzyl alcohol (cross-sensitivity with other benzodiazepines may exist); parenteral form is not for intrathecal or epidural injection; narrow-angle glaucoma (not in product labeling, however, benzodiazepines are contraindicated); pregnancy; concurrent use with protease inhibitors like amprenavir and ritonavirP: May cause severe respiratory depression, respiratory arrest, or apnea. Use with extreme caution, particularly in noncritical care settings. Appropriate resuscitative equipment and qualified personnel must be available for administration and monitoring. Initial dosing must be cautiously titrated and individualized, particularly in elderly or debilitated patients, patients with hepatic impairment (including alcoholics), or in renal impairment, particularly if other CNS depressants (including opiates) are used concurrently. Initial doses in elderly or

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 479: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexdebilitated patients should not exceed 2.5 mg. Use with caution in patients with respiratory disease or impaired gag reflex. Use during upper airway procedures may increase risk of hypoventilation. Prolonged responses have been noted following extended administration by continuous infusion (possibly due to metabolite accumulation) or in the presence of drugs which inhibit midazolam metabolism. Causes CNS depression (dose-related) resulting in sedation, dizziness, confusion, or ataxia which may impair physical and mental capabilities. Patients must be cautioned about performing tasks which require mental alertness (ie, operating machinery or driving). A minimum of 1 day should elapse after midazolam administration before attempting these tasks. Use with caution in patients receiving other CNS depressants or psychoactive agents. Effects with other sedative drugs or ethanol may be potentiated. Benzodiazepines have been associated with falls and traumatic injury and should be used with extreme caution in patients who are at risk of these events (especially the elderly).

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 480: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMidazolam causes anterograde amnesia. Paradoxical reactions, including hyperactive or aggressive behavior have been reported with benzodiazepines, particularly in adolescent/pediatric or psychiatric patients. Does not have analgesic, antidepressant, or antipsychotic properties. Benzodiazepines have been associated with dependence and acute withdrawal symptoms on discontinuation or reduction in dose. Acute withdrawal, including seizures, may be precipitated after administration of flumazenil to patients receiving long-term benzodiazepine therapy. ES: >10%: Decreased tidal volume and/or respiratory rate decrease, apnea 1-10%: Drowsiness, oversedation, headache, Nausea, vomiting, local reactions at injection site (severity less than diazepam), Coughing, Physical and psychological dependence with prolonged use, hiccups IO: CYP3A3/4 enzyme substrate Verapamil, troleandomycin, miconazole, itraconazole, nifedipine, grapefruit juice, diltiazem, fluconazole, ketoconazole,

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 481: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexclarithromycin, and erythromycin, protease inhibitors like amprenavir and ritonavir may increase the serum concentrations and effects of midazolam via CYP3A4 inhibition If narcotics or other CNS depressants are administered concomitantly, the midazolam dose should be reduced by 30% if <65 years of age, or by at least 50% if >65 years of agePreg: DNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 482: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexEstazolamIntermediate-acting benzodiazepine Depresses all levels of CNS (eg, limbic and reticular formation), possibly by increasing activity of GABA. Half-life is 10-24 h, and peak action is 2 h.I: Short-term management of insomniaBSO: Tablet: 1 mg, 2 mgD: 1 mg PO hs; may require 2 mgStart with 0.5 mg PO hs in debilitated or small elderly patientsElderly: 0.5-1 mg PO qhsKI: Hipersensitif; narrow-angle glaucoma; untreated obstructive sleep apnea; history of substance abuseIO: Increases toxicity with coadministration of phenothiazines, barbiturates, alcohols, and MAOIsPreg: XP: Hepatic disease, low albumin levels, or renal or pulmonary disease; causes residual daytime sedation, impairs cognition, and increases risk of falls Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 483: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTriazolamBenzodiazepineI: Short-term treatment of insomniaBSO: Tablet: 0.125 mg, 0.25 mgD: Onset of action is rapid, patient should be in bed when taking medication: Adults: 0.125-0.25 mg at bedtime KI: Hypersensitivity to this drug or any component of its formulation (cross-sensitivity with other benzodiazepines may exist); concurrent therapy with CYP3A4 inhibitors (such as ketoconazole, itraconazole, protease inhibitors and nefazodone); pregnancyP: Should be used only after evaluation of potential causes of sleep disturbance. Failure of sleep disturbance to resolve after 7-10 days may indicate psychiatric or medical illness. A worsening of insomnia or the emergence of new abnormalities of thought or behavior may represent unrecognized psychiatric or medical illness and requires immediate and careful evaluation.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 484: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCauses CNS depression (dose-related) resulting in sedation, dizziness, confusion, or ataxia which may impair physical and mental capabilities. Patients must be cautioned about performing tasks which require mental alertness (ie, operating machinery or driving). Use with caution in patients receiving other CNS depressants or psychoactive agents. Effects with other sedative drugs or ethanol may be potentiated. Benzodiazepines have been associated with falls and traumatic injury and should be used with extreme caution in patients who are at risk of these events (especially the elderly). Use caution in patients with depression, particularly if suicidal risk may be present. Use with caution in patients with a history of drug dependence. Benzodiazepines have been associated with dependence and acute withdrawal symptoms on discontinuation or reduction in dose. Acute withdrawal, including seizures, may be precipitated after administration of flumazenil to patients receiving long-term benzodiazepine therapy. Paradoxical reactions, including hyperactive or aggressive behavior have been reported with benzodiazepines, particularly

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 485: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexin adolescent/pediatric or psychiatric patients. Does not have analgesic, antidepressant, or antipsychotic properties. ES: >10%: Drowsiness 1- 10%: Headache, dizziness, nervousness, lightheadedness, ataxia, Nausea, vomiting IO: CYP3A3/4 and 3A5-7 enzyme substrate Cimetidine, ciprofloxacin, clarithromycin, clozapine, CNS depressants, diltiazem, disulfiram, digoxin, erythromycin, ethanol, fluconazole, fluoxetine, fluvoxamine, grapefruit juice, isoniazid, itraconazole, ketoconazole, labetalol, levodopa, loxapine, metoprolol, metronidazole, miconazole, nefazodone, omeprazole, phenytoin, rifabutin, rifampin, troleandomycin, valproic acid, protease inhibitors like amprenavir and ritonavir, verapamil may increase the serum level and/or toxicity of triazolam; monitor for altered benzodiazepine response Preg: X BSO: Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 486: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexH. Anti DepressanAmitriptylineFluoxetineParoxetineSertralineMoclobemideVenlafaxineImipramineClomipramineFluvoxamineMirtazapineMianserinDuloxetineTianeptine MaprotilineCitalopramLithium carbonateAmoxapine

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 487: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAmitriptyline Blocks reuptake of norepinephrine and serotonin. Decreases pain by inhibiting spinal neurons involved in pain perception.I: Depressive illness, nocturnal enuresis in children > 7 years, Nerve pain & Preventing migraine (unlicensed use).BSO: Injection: 10 mg/mL Tablet: 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg D: 10-150 mg PO hs; initially administer as smaller divided increments and gradually titrate up to an effective level with a max 150 mg PO qhsKI: Hipersensitif; administration of MAOIs in past 14 d; history of seizures; cardiac arrhythmias; glaucoma; urinary retentionIO: Phenobarbital may decrease effects; coadministration with CYP2D6 enzyme system inhibitors (eg, cimetidine, quinidine) may increase amitriptyline levels; amitriptyline inhibits hypotensive effects of guanethidine; may interact with thyroid medications, alcohol, CNS depressants, barbiturates, and disulfiramPreg: D

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 488: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexP: Caution in cardiac conduction disturbances, history of hyperthyroidism, and renal or hepatic impairment; avoid using in elderly patientsNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 489: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFluoxetineFDA-approved for OCD and panic disorder. I: Depressive illness, obsessive-compulsive disorder, bulimia nervosa, Premature ejaculationBSO: Capsule: 10 mg, 20 mg, 40 mg Liquid: 20 mg/5 mL Tablet: 10 mg, 20 mg D: Kaps: Depression:Adults— 20 mg 1x/hr pagi hari. Max 80 mg/hr. Children > 8= 10-20 mg 1x pagi hari. Bulimia nervosa: Adults—60 mg 1x pagi hari. Max 80 mg/hr.Obsessive-compulsive disorder:Adults—20 mg 1x pagi hari. Max 80 mg/hr.Children > 7= 10 mg 1x pagi hari. Max 60 mg/hrPanic disorder:Adults— 10 mg 1x/hr pagi hari. Max 60 mg/hr. For premenstrual dysphoric disorder:Adults=20 mg 1x/hr pagi hari selama 14 hari. Max 80 mg/hr.

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 490: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexChildren > 8= 10-20 mg 1x pagi hari. KI:Hipersensitif; concurrently taking MAOIs or took them in the last 2 wkIO:Increases toxicity of diazepam and trazodone by decreasing clearance; increases toxicity of MAOIs and highly protein-bound drugsPreg: CP:Caution in hepatic impairment and history of seizures; MAOIs should be discontinued at least 14 d before initiating therapy Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 491: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexParoxetineFDA-approved for panic disorder, depression, social anxiety disorder, generalized anxiety disorder, posttraumatic stress disorder, and OCD.I: Depressive illness, Generalised anxiety disorder (GAD), obsessive-compulsive disorder, panic disorder, Post-traumatic stress disorder, social phobia.BSO: Tab 20 mgD: Adults= 20 mg 1x pagi hari. Max 50 mg/hr.KI: Hipersensitif; concurrent administration with MAOIs or administering within 14 days of discontinuing an MAOIIO: Phenobarbital and phenytoin decrease effects; alcohol, cimetidine, sertraline, phenothiazines, and warfarin increase toxicityPreg: CP: Caution in history of seizures, mania, renal disease, and cardiac disease Nama Dagang: Seroxat

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 492: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSertralineI: Depression in adults, obsessive-compulsive disorder, Post-traumatic stress disorder in adult womenBSO: Concentrate, oral: 20 mg/mL Tablet: 25 mg, 50 mg, 100 mg D: Oral: Elderly: 1st 25 mg/day in the morning, increase by 25 mg/day increments every 2-3 days if tolerated to 50-100 mg/day; additional increases may be necessary; max: 200 mg/day KI: Hipersensitif; within 14 d of taking an MAOIIO: Increases toxicity of MAOIs, diazepam, tolbutamide, and warfarinPreg: CP: Caution in preexisting seizure disorders and those who have experienced a recent myocardial infarction, have unstable heart disease, and hepatic or renal impairment Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 493: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMoclobemideI: Major depression, social phobia.BSO: Tab 150 mg

D: 150 mg 2x/hr. Max 600 mg/hr.KI: Children, Schizophrenia and schizo-affective disorders, Acute states of confusion, phaeochromocytoma.P: Severely decreased liver function, manic depression, Agitated and excited states, Thyrotoxicosis.ES: Disturbed sleep, Dizziness, diarrhoea, constipation, nausea, vomiting or abdominal pain, Headache, Anxiety and restlessness, Agitation, paraesthesia, Dry mouth, Visual disturbances, oedema, Skin reactions such as rash and itch, ConfusionIO: Preg:: A, B, C, D, X Nama Dagang: Aurorix

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 494: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexVenlafaxineSelectively inhibits presynaptic serotonin reuptake, norepinephrine (at doses of approximately 150 mg PO qam), and dopamine (at doses of approximately 150-225 mg qam).I: Depressive illness, depression associated with anxiety.BSO: Kaps 75 mgD: * For mental depression & anxiety:75 mg 1x/hari. Max 225 mg/hr.* For panic disorder: 37.5 mg 1x/hr for 7 hari. Max 225 mg/hr.KI: Hipersensitif; MAOIs in past 2 wkIO: Cimetidine, MAOIs, sertraline, fluoxetine class IC antiarrhythmics, TCAs, and phenothiazine may increase effects; serotonin syndromePreg: CP: Anxiety, anorexia, sedation, dry mouth, nervousness, dizziness, insomnia, headaches, nausea, increased BP, and sexual dysfunction may occur; taper over 1-2 wk upon discontinuationNama Dagang: Efexor XR

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 495: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexImipramineTricyclic antidepressant that has norepinephrine and serotonin reuptake-inhibition properties. I: Depression, enuresisBSO: Tab salut selaput 25 mgD: Maximum antidepressant effect may not be seen for 2 or more weeks after initiation of therapy. Depression: 1.5 mg/kg/day with dosage increments of 1 mg/kg every 3-4 days, max 5 mg/kg/day in 1-4 divided doses; monitor carefully especially with doses > 3.5 mg/kg/day Enuresis: > 6 years: 1st 10-25 mg at bedtime, increase by 25 mg/day; max 2.5 mg/kg/day6-12 y: 50 mg at bedtime > 12 y: 75 mg at bedtime Adjunct in the treatment of cancer pain: Initial: 0.2-0.4 mg/kg at bedtime; increased by 50% every 2-3 days up to 1-3 mg/kg/dose at bedtime Adolescents: Oral: Initial: 25-50 mg/day; increase gradually; maximum: 100 mg/day in single or divided doses

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 496: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAdults: Oral: Initial: 25 mg 3-4 times/day, max 300 mg/day I.M.: Initial: Up to 100 mg/day in divided doses; change to oral as soon as possible Elderly: Initial: 10-25 mg at bedtime; increase by 10-25 mg every 3 days for inpatients and weekly for outpatients if tolerated; average daily dose to achieve a therapeutic concentration: 100 mg/day; range: 50-150 mg/day KI:Hipersensitif; narrow-angle glaucoma; acute recovery phase following myocardial infarction; history of bipolar disorders; patients taking MAOIs or fluoxetine or those who took them in the previous 2 wkIO:Increases toxicity of sympathomimetic agents such as isoproterenol and epinephrine by potentiating effects and inhibiting antihypertensive effects of clonidinePreg: CP:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 497: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMay impair mental or physical abilities required for performance of potentially hazardous tasks; caution in cardiovascular disease, conduction disturbances, seizure disorders, urinary retention, hyperthyroidism, or those receiving thyroid replacement; an ECG may be warranted prior to initiation of therapy with imipramine, repeat after dose stabilized to monitor any potential widening of QRSNama Dagang: Tofranil

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 498: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexClomipramineTricyclic antidepressant with potent NE and 5-HT reuptake inhibition.I: Depressive illness, Phobic or obsessional disorders, cataplexy, narcolepsy.BSO: Capsule: 25 mg, 50 mg, 75 mg D: Oral: Initial: Adults: 25 mg/day. Increase to 100 mg/day the first 2 weeks, max 250 mg/day KI: Hipersensitif; concurrent use of MAOI or other TCAIO: Potentiates CNS depressants, anticholinergics, sympathomimetics, and other protein-bound drugs; potentiated by CYP2D6 inhibitors; SSRIsPreg: CP: Suicidal tendencies or risk of overdose; seizure disorder; cardiac disease; glaucoma; urinary retention Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 499: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexFluvoxamineFDA approved for OCD in children (8-17 y) and adults. I: Depressive illness, obsessive-compulsive disorder.BSO: Tab salut selaput 50 mgD: Obsessive-compulsive disorder or social phobia:100 mg 1x at bedtime. Max 300 mg/hari.Paed.: 25-200 mg PO qdKI: Hipersensitif; patients currently receiving MAOIs or those who took them in previous 2 wkIO: Risk of a hypertensive crisis increases with coadministration with MAOIs; potentiates effect of triazolam and alprazolam and thus, when taking them concurrently, dose should be reduced by at least 50%; also reduce dose of theophylline by one third and monitor plasma levels if taking it concurrently with fluvoxamine; alcohol, cimetidine, sertraline, phenothiazines, and warfarin increase toxicityPreg: CP: liver disease, history of seizures or suicidal tendencies Nama Dagang: Luvox

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 500: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMirtazapineExhibits both noradrenergic and serotonergic activity. In cases of depression associated with severe insomnia and anxiety, shown to be superior to other SSRI drugs.I: Depressive illness.BSO: Tab 30 mgD: 15 mg PO hs initially; may increase in 15-mg increments q1-2wk, max 45 mg hsKI: Hipersensitif; MAOI within 14 dIO: May increase effect of CNS depressants; concurrent administration with MAOI may trigger hypertensive crisisPreg: CP: May cause drowsiness; discontinue use if patient develops sore throat, fever, or other signs of infection; suicidal ideation is inherent in depression and may persist until significant remission occurs; severe neutropenia reported in clinical trials Nama Dagang: Remeron

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 501: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMianserinI: Depressive illness.BSO: Tab 10 mgD: Awal 30-40 mg malam atau dg dosis terbagi. Durasi 30-90 mg/hr. Usia lanjut < 30 mg/hrKI: Children < 18 years, Severe liver disease, Breastfeeding, Mania, People who have taken a monoamine oxidase inhibitor antidepressant (MAOI) in the last two weeks.P: Elderly, Decreased liver & kidney function, Heart disease, heart block, arrhythmias, prostatic hypertrophy, Closed angle glaucoma, History of epilepsy, People at risk of seizures, Diabetes, Psychotic illness, manic depression, porphyrias.ES: Drowsiness, Dizziness, postural hypotension, arthralgia, oedema, Skin rash, Sweating, Tremor, Disturbances of liver function, jaundice, Disturbances in the normal numbers of blood cells in the blood, convulsions, Breast enlargement and tenderness, Production of breast milk, Sexual problemsPreg:: A, B, C, D, X Nama Dagang: Tolvon

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 502: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexDuloxetine-- Potent inhibitor of neuronal serotonin and norepinephrine reuptake. Antidepressive action is theorized to be due to serotonergic and noradrenergic potentiation in CNS.I: Depressive illness, diabetic peripheral neuropathic pain.BSO: Kaps salut enteric 30mg, 60mgD: Depression: 40 mg/hari terbagi dalam 1-2 dosis.Diabetic peripheral neuropathy pain: 60 mg 1x/hr.KI:Hipersensitif; uncontrolled narrow-angle glaucoma; do not administer within 14 d after stopping MAOIs; do not initiate MAOIs within 5 d of stopping duloxetineIO:Metabolized by CYP1A2 and CYP2D6; coadministration with drugs that inhibit CYP1A2 (eg, fluvoxamine, cimetidine, ciprofloxacin, enoxacin) may increase blood levels and toxicity; coadministration with drugs that inhibit CYP2D6 (eg, paroxetine, fluoxetine, quinidine) may increase blood levels and toxicity; moderately inhibits CYP2D6 and may decrease elimination of

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 503: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCYP2D6 substrates (eg, tricyclic antidepressants, phenothiazines [eg, thioridazine], type 1C antiarrhythmics [eg, propafenone, flecainide]); coadministration with MAOIs may cause serious, sometimes fatal, reactions that include hyperthermia, rigidity, myoclonus, autonomic instability, mental status changes, including extreme agitation, delirium, and coma Preg: CP:Observe closely for clinical worsening and suicidality when initiating treatment or following dosage change; gradually decrease dose when discontinuing, do not abruptly discontinue; caution with hepatic impairment or end-stage renal disease; may cause slight blood pressure increase; may activate mania or hypomania; common adverse effects include nausea, dry mouth, constipation, decreased appetite, fatigue, somnolence, and increased sweating Nama Dagang: Cymbalta

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 504: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexTianeptineI: Episode depresi mayorBSO: Tab 12.5 mg

D: 12.5 mg 3x/hr KI: Anak 15 th. Ada jarak 2 minggu setelah penghentian terapi MAOI. Penghentian Tianeptine 24 jam bila akan diganti MAOIP: Hamil, menyusui. Pengawasan thd pasien resiko bunuh diri.ES: JarangIO: MAOIPreg:: A, B, C, D, X Nama Dagang: Stablon

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 505: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMaprotilineI: Depression and anxiety associated with depressionChronic neurogenic pain BSO: Tablet: 10 mg, 25 mg, 50 mg, 75 mgD: 25 mg 1-3x/hr. Max 150 mg/hr.KI: Hypersensitivity to maprotiline; use of monoamine oxidase inhibitors within 14 days; use in a patient during the acute recovery phase of MIES: Skin rash, redness, swelling, or itching, Constipation (severe), Nausea or vomiting, Shakiness or trembling, convulsions, Unusual excitement, Weight lossRare: Breast enlargement (males/females), Confusion (especially in the elderly), Difficulty in urinating, Fainting, Hallucinations, Inappropriate secretion of milk—in females, Irregular heartbeat, Sore throat and fever, Swelling of testicles, Yellow eyes or skinPreg: BNama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 506: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCitalopramEnhances serotonin activity due to selective reuptake inhibition at the neuronal membrane. Also has the advantage of fewer potential drug IO:. Citalopram is a 50:50 racemate of r- and s-citalopram.I: Depressive illness, Panic disorder with/without agoraphobia. BSO : Tab 20 mg D: 20 mg 1x/hr. Max 60 mg/hr.KI: Hipersensitif; concurrent MAOI therapyIO: May be potentiated by azole antifungals, omeprazole, and macrolides; serotonin syndrome may be induced by buspirone, tramadol, MAOIs, and nefazodonePreg: CP: Cirrhosis; suicidal tendencies; SIADH; DM; breastfeeding; common adverse effects include fatigue and sexual dysfunctionNama Dagang:Cipram

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 507: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexLithium carbonateI: Mania and hypomania, 'mood stabiliser', recurrent depression, Aggressive or self-harming behaviourBSO: Tab 200 mg, 400 mgD: Capsules, tablets, syrup: Dws: 300-600 mg 3x/hr.Children <12: 15-20 mg/kg/hr, terbagi 2-3 dosisSlow-release capsules, extended-release tablets):Adults: 300-600 mg 3x/hr or 450-900 mg 2x/hr.Maintenance, preventive use: 400-1200 mg PO qdAcute manic episode: 600-2400 mg PO qdPaed.6-12 years: 15-60 mg/kg/d PO divided tid/qid; max D:KI:Hipersensitif; renal disease or damage (renal function and clearance are critical in maintaining proper levels); history or evidence of brain damage; cardiovascular disease; generalized severe debilitationIO:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 508: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexIncreases toxicity of thiazide diuretics, haloperidol, phenothiazines, neuromuscular blockers, carbamazepine, fluoxetine, and ACE inhibitorsPreg: DP:Patient should have adequate renal function as evidenced by elevated creatinine levels or BUN levels, and they should drink plenty of fluids to prevent dehydration; excessive sodium loss can produce lithium toxicity (avoid excessive sweating); use lower doses in elderly individuals; do not perform ECT when being administered; avoid rapid increases in dosingAnything causing hyponatremia increases levels and could cause toxicity; toxicity is closely related to serum levels and can occur at therapeutic doses; serum lithium determinations are required to monitor therapy Nama Dagang:Frimania

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 509: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexAmoxapineI: Neurotic or reactive depressive disorder as well as endogenous and psychotic depression; depression accompanied by anxiety or agitationBSO: Tablet: 25 mg, 50 mg, 100 mg, 150 mgD: Once symptoms are controlled, decrease gradually to lowest effective dose. Maintenance dose is usually given at bedtime to reduce daytime sedation. Oral: Adolescents: Initial: 25-50 mg/day; increase to 100 mg/day; divided/ single dose at bedtime Adults: Initial: 25 mg 2-3 times/day, increased to 100 mg 2-3 times/day; Elderly: Initial: 25 mg at bedtime increased by 25 mg weekly for outpatients and every 3 days for inpatients if tolerated; usual dose: 50-150 mg/day, but doses up to 300 mg may be necessary Maximum daily dose: Inpatient: 600 mg, Outpatient: 400 mg

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 510: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexKI: Hypersensitivity to amoxapine; use of monoamine oxidase inhibitors within past 14 days; recovery from acute myocardial infarctionP: May cause sedation, resulting in impaired performance of tasks requiring alertness (ie, operating machinery or driving). Sedative effects may be additive with other CNS depressants and/or ethanol. The degree of sedation is moderate relative to other antidepressants. May worsen psychosis in some patients or precipitate a shift to mania or hypomania in patients with bipolar disease. May increase the risks associated with electroconvulsive therapy. This agent should be discontinued, when possible, prior to elective surgery. Therapy should not be abruptly discontinued in patients receiving high doses for prolonged periods. May cause orthostatic hypotension (risk is moderate relative to other antidepressants) - use with caution in patients at risk of hypotension or in patients where transient hypotensive episodes would be poorly tolerated (cardiovascular disease or cerebrovascular disease). The degree of anticholinergic

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 511: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexblockade produced by this agent is moderate relative to other cyclic antidepressants - use caution in patients with urinary retention, benign prostatic hypertrophy, narrow-angle glaucoma, xerostomia, visual problems, constipation, or history of bowel obstruction. Use caution in patients with depression, particularly if suicidal risk may be present. Use with caution in patients with a history of cardiovascular disease (including previous MI, stroke, tachycardia, or conduction abnormalities). The risk of conduction abnormalities with this agent is moderate relative to other antidepressants. May lower seizure threshold - use caution in patients with a previous seizure disorder or condition predisposing to seizures such as brain damage, alcoholism, or concurrent therapy with other drugs which lower the seizure threshold. Use with caution in hyperthyroid patients or those receiving thyroid supplementation. Use with caution in patients with hepatic or renal dysfunction and in elderly patients. ES: >10%: Drowsiness, Xerostomia, constipation

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 512: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Index1-10%: Dizziness, headache, confusion, nervousness, restlessness, insomnia, ataxia, excitement, anxiety, Edema, skin rash, Elevated prolactin levels, Nausea, Tremor, weakness, Blurred vision, Diaphoresis IO: CYP1A2, 2C9, 2C19, 2D6, and 3A3/4 enzyme substrate Amoxapine inhibits the antihypertensive response to bethanidine, clonidine, debrisoquin, guanadrel, guanethidine, guanabenz, guanfacine; monitor BP; consider alternate antihypertensive agent Abrupt discontinuation of clonidine may cause hypertensive crisis, amoxapine may enhance the response Use with altretamine may cause orthostatic hypertension Amoxapine may be additive with or may potentiate the action of other CNS depressants (sedatives, hypnotics, or ethanol) With MAO inhibitors, hyperpyrexia, hypertension, tachycardia, confusion, seizures, and deaths have been reported (serotonin syndrome); this combination should be avoided Amoxapine may increase the prothrombin time in patients stabilized on warfarin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 513: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCimetidine and methylphenidate may decrease the metabolism of amoxapine; additive anticholinergic effects seen with other anticholinergic agents The SSRIs, to varying degrees, inhibit the metabolism of TCAs and clinical toxicity may result Use of lithium with a TCA may increase the risk for neurotoxicity Phenothiazines may increase concentration of some TCAs and TCAs may increase concentration of phenothiazines; monitor for altered clinical response TCAs may enhance the hypoglycemic effects of tolazamide, chlorpropamide, or insulin; monitor for changes in blood glucose levels Cholestyramine and colestipol may bind TCAs and reduce their absorption; monitor for altered response TCAs may enhance the effect of amphetamines; monitor for adverse CV effects Verapamil and diltiazem appear to decrease the metabolism of imipramine and potentially other TCAs; monitor for increased TCA concentrations. The pressor response to I.V. epinephrine,

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 514: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, Indexnorepinephrine, and phenylephrine may be enhanced in patients receiving TCAs; this combination is best avoided. Grapefruit juice,amprenavir, indinavir, ritonavir may inhibit the metabolism of clomipramine and potentially other TCAs; monitor for altered effects; a decrease in TCA dosage may be required Quinidine may inhibit the metabolism of TCAs; monitor for altered effect Combined use of anticholinergics with TCAs may produce additive anticholinergic effects; combined use of beta-agonists with TCAs may predispose patients to cardiac arrhythmias

Preg: CBSO: Nama Dagang: Asendin

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 515: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexI. Stimulan SSP & Obat ADHDMethylphenidate

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 516: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMethylphenidateI: Attention deficit hyperactivity disorder (ADHD).BSO: Tablet: 10 mg, 20 mg Kaps 20 mg, 30 mg, 40 mgD: Deficit hyperactivity disorder (ADHD): Tab:+ Adults= 5-20 mg 2-3x/hr a.c+ Anak 6th= 5 mg 2x/hr. Titrasi per minggu. Max 60 mg/hr.Etended -release tablets:+ Dws & anak > 6th=10-20 mg 1x pagi hr a.c. Max 60 mg/hrNarcolepsy: Tab:+ Adults= 5-20 mg 2-3x/hr a.cif unable to sleep because of taking medication late in day, take last dose before noon or 6 pmKI:Hipersensitif; psychosis; agitation; hyperthyroidism; uncontrolled hypertension; cardiac disease; glaucoma; current MAOI or within past 2 wk; substance abuseIO:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 517: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexReduces effects of guanethidine and bretylium; toxicity of phenytoin, TCAs, warfarin, primidone, and phenobarbital may increase when administered concurrently with methylphenidate; MAOIs increase toxicity of methylphenidatePreg: CP:Caution in dementia, seizures, and hypertension Nama Dagang:Ritalin/ Ritalin SR/ Ritalin LA

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 518: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexJ. Nootropik & NeurotonikPiracetamMecobalaminPyritinolSulbutiamineCitrullineNimodipine

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 519: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPiracetamI: Gejala involusi yg berhub dg proses penuaan, misal: lupa, asthenia, ggn adaptasi, ggn reaksi psikomotor, alkoholisme kronik & ketergantungan, Sindrom pasca trauma, myoclonus.BSO: Kaps 400 mg, 800 mg, 1.2 gSir 500 mg/5ccAmp 200 mg/cc, 1 g/5ccD: 2.4 g/hr terbagi dalam 3 dosis Amp 1 g 3x/hr IM/IV KI: Breastfeeding, Children < 16 years, Moderate to severely decreased liver & kidney function, Pregnancy.P: Decreased kidney function, Elderly peopleES: Diarrhoea, insomnia, Depression, Skin rashes, Weight gain, somnolence, Nervousness, HyperkinesiaIO: Jangan diberikan bersama ekstrak tiroidPreg:: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 520: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexMecobalaminI: Neuropati perifer, tinnitus, vertigo, anemia megaloblastik krn defisiensi vit B12.BSO: Kapl 250 mcg, 500 mcg. Amp 500 mcgD: 500 mcg 3x/mggu IO/IV/IM KI: P: Neonatus, bayi premature, anakES: Anoreksia, mual, diare, ruam kulitIO: Preg:: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 521: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexPyritinol I: Pasca trauma otak, perdarahan otak, keracunan & radang otak, gejala degenerasi otak sehubungan dg ggn metabolisme & sirkulasi otak. Daya pikir menurun, pelupa, sukar konsentrasiBSO: Drag 100 mg, forte 200 mgLar 100 ccAmp 20 mgD: Dws 200 mg 3x/hr. terapi minimal 6-8 mgg. Amp min 3 pasang/hrKI: P: ES: IO: Preg:: A, B, C, D, X Nama Dagang:

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 522: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexSulbutiamineI: Terapi simtomatik asthenia fungsionalBSO: Drag 200 mgD: 200-600 mg 1x/hari atau dlm dosis terbagi. Umumnya 2 tab/

hari pd waktu sarapanKI: P: ES: Agitasi ringan pd usia lanjut. Reaksi alergi kulitIO: Preg: A, B, C, D, X Nama Dagang:Arcalion 200

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 523: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexCitrullineI: Membantu & memperbaiki metabolisme tubuh.Menjaga kebugaran tubuh saat kerja keras,olahraga & masa pemulihan.BSO: Sachet D: 1 sachet 3x/hrKI: P: ES: IO: Preg:: A, B, C, D, X Nama Dagang:Stimol

Genghis Khun ([email protected],nafanakhun.wordpress.com)

Page 524: Daftar Obat Generik

Nama Generik Obat, Kembali ke: Awal, Daftar Isi, IndexNimodipineI: Bleeding into the space between the skull and the brain (sub-arachnoid haemorrhage)BSO: Tab 30 mg, Lar Infus 10 mg/50ccD: Adults: 60 mg q4 hours for 21 days.Infus 1-2 mg/jam selama 5-14 hari. Lalu selama 7 hari berikutnya 2 tab 6x/hr.KI: HypersensitivityP: Kidney disease, cerebral oedemaES: Headache, tachycardia, bradycardia, facial flushing, hypotension, Nausea, diarrhoea, constipation, nausea, vomiting or abdominal pain, Feeling of warmthIO: Preg: C Nama Dagang:Nimotop

Genghis Khun ([email protected],nafanakhun.wordpress.com)