Tablet

1. Bahan Pelicin

a. Mg Stearat : 0,1-2%

b. Talkum : 1-5 %

Daftar Pustaka:

Gunsel, W. C., dan Kanig, J. L., 1976, Tablet in Lachman, L., Lieberman, H. A., Kanig, J. L., (Editors) The Theory dan Practice of Industrial Pharmacy, 2nd Edition, 321, 327-329, Lea dan Febiger, Philadelphia.

2. Bahan Pengikat

a. Gelatin : 2-5% (Voigt,1994. Buku Pelajaran Teknologi Farmasi. UGM Press: Yogyakarta).

b. Avicel PH : 20-90% (Raymond, Sheskey and Quin,2009, Handbook of Pharmaceutical Excipient, Pharmaceutical Press : USA).

3. Bahan Penghancur

Explotab: 2-8% (Raymond, Sheskey and Quin,2009, Handbook of Pharmaceutical Excipient, Pharmaceutical Press : USA).

4. Bahan Pengisi (Ad 100%)

a. Dicalcium fosfat anhidrat :

b. Amylum:

Formula Cetak Langsung (PCT-250)

Parasetamol 250 mg(Zat Aktif)

Avicel PH2 25 %(Pengikat dan Penghancur)

Mg Stearat 1 %

Dikalsium Fosfat Anhidrat ad 500 mg(Pengisi)

Buat 200 tablet @ 500 mg

Perhitungan:

Parasetamol : 250 mg x 200 tablet = 50 gram

Avicel PH2 : 25/100 x 500 mg x 200 tablet = 25 gram

Mg Stearat: 1/100 x 500 mg x 200 = 1 gram

Dikalsium Fosfat: Total berat tablet-bahan lain = 100 gram 76 gram = 24 gram

Formula Granulasi Basah ( PCT-250)

Parasetamol 250 mg

Gelatin 5%

Mg Stearat0,2 %

Talk1,8 %

Explotab4 %

Amilum Manihotad 500 mg

Buat 200 tablet @ 500 mg

Perhitungan:

Parasetamol: 250 mg X 200 = 50 gram

Mg Stearat : 0,2/100 x 500 mg x 200 = 200 mg

Talk: 1,8% x 500 mg x 200 = 1,8 gram

Gelatin: 5% x 500 mg x 200 = 5 gram

Explotab: 4 % x 500 mg x 200 = 4 gram

Amilum manihot: 100 gram- 61 gram = 39 gram