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Semnas dan Muswil ISMAFARSI Sumatera II

Fakultas Farmasi Unand- 23 April 2016

PADANG

Deddi Prima Putra

Penduduk Indonesia

Sumber : diolah dr BPS 2015*) Perkiraan

0 50 100 150 200 250 300 350

1971

1980

1990

1995

2000

2010

2015*

2020*

2025*

2030*

2035*

Persentase Penduduk yang Mengobati SendiriSelama Sebulan Terakhir (%)

0

5

10

15

20

25

30

35

40

45

50

Ind (rerata)

Sumbar

Sumber : diolah dr BPS 2015

Persentase penduduk yang mengalami keluhan kesehatan sebulan yang lalu

0 5 10 15 20 25 30 35

2000

2001

2003

2004

2005

2006

2007

2008

2009

2010

2011

2011

2012

2013

2014

2015

Sumber : diolah dr BPS 2015

Persentase Penduduk yang Menggunakan

Obat Tradisional (2000-2014)

0 5 10 15 20 25 30 35 40

1998

2000

2003

2005

2007

2009

2011

2013

Sumber : diolah dr BPS 2015

Definisi Herbal Medicine

Herbal Medicine merupakan bahan yang digunakanuntuk Pengobatan Tradisional (Traditional Medicine)

WHO mendefinisikan Traditional Medicine : It is the sum total of the knowledge, skills and practices based on the theories, beliefs and experiences indigenous to different cultures, whether explicable or not, used in the maintenance of health, as well as in the prevention, diagnosis, improvement or treatment of physical and mental illnesses

Other terms; complementary/alternative/non-conventional medicine

Traditional use of herbal medicines

Herbal medicines include herbs, herbal materials, herbal preparations and finished herbal products, that contain as active ingredients parts of plants, or other plant materials, or combinations.

Category Herbal Medicine by WHO;

Category 1: Indigenous herbal medicines

Category 2: Herbal medicines in systems

Category 3: Modified herbal medicines

Category 4: Imported products with a herbal medicine base

Why Herbal Medicine ? Jutaan penduduk di negara berkembang selalu

menggunakan ‘Herbal Medicine’ karena merekapercaya dan terlebih kerena merupakan ‘their system of medicine’

Mudah diperoleh, ketersediaan setiap waktu para‘Healer/ Dukun’, keyakinan akan bahan alam (natural thing) khususnya dipedesaan.

Harga yang murah dan terjangkau

Amankah Herbal Medicine ?

There is a widespread misconception that “natural” always means “safe”, and

A common belief that remedies from natural origin are harmless and carry no risk.

However, some medicinal plants are inherently toxic.

WHO established a minimum requirements for assessment of safety of herbal medicines:

Category 1: safety established by use over long time

Category 2: safe under specific conditions of use (such herbal medicines should preferably be covered by well-established documentation)

Category 3: herbal medicines of uncertain safety (the safety data required for this class of drugs will be identical to that of any new substance)

Usaha untuk Meningkatkan Safetydan Efficacy Penggunaan Herbal Koordinasi dan Harmonisasi masing-masing negara

dalam menghasilkan regulasi ttg Herbal Medicine.

Quality Assurance produk herbal seperti ; Implementasi Good Agricultural and Collection Practice (GACP), Good Manufacturing Practice (GMP), dll.

Farmacovigilance dan

Pengawasan iklan.

Penyusunan Monografi dan Farmakope Herbal.

Herbal Medicine di Indonesia

Perka BPOM RI No HK. 00.05.4.2411

Potensi Herbal Indonesia

1. Indonesia merupakan mega-centerkeanekaragaman hayati dunia (2nd in the world)

2. Memiliki 30.000 species tumbuhan dansekitar 9.600 diantaranya tumbuhanberkhasiat.

3. 300 spesies telah digunakan sebagaibahan obat tradisional (OT) oleh industriOT.

GLOBAL HERBAL MARKET INCL NUTRACEUTICALS

$ 70.4 BILLION

EXCLUSIVE GLOBAL HERBAL MARKET

$ 24.2 BILLION

GLOBAL SCENARIO

0

5

10

15

20

25

US

$

Bil

lio

n

Year

1994

Year

1997

Year

1999

Year

2002

Global Sales of Herbal Medicine

49%

31%

70%

10%

33%

49%42%

12.414.0

24.18

19.58

From CK Katiyar, 2006

Strategi Pengembangan Herbal Indonesia

From Dir. Bina Prod dan Distribusi Kefarmasian

From Dir. Bina Prod dan Distribusi Kefarmasian

Jenis Tumbuhan Obat yang Banyak Digunakan

From Gunawan, 2014

Industri Obat Tradisional di Indonesia

Form, Sido Muncul report, 2014

Form, Sido Muncul report, 2014

Jumlah Produk Teregistrasi pada BPOM

Form, Sido Muncul report, 2014

Potensi dan Pemanfaatan Tanaman Lokaldalam Herbal Medicine

Pegagan = Centella asiatica

Tahun Perkembangan Kegunaan

3000 yl Indian Ayurvedic Asma, bronchitis, dropsi, elepantiasis, lepra, ganggianginjal, leucorhoea, gangguan kulit, uretritis

2000 yl Chinese Shennong Herbal Leucorrhoe, fever

1884 French Pharmacopoeia

1983 British Herbal Pharmacopoeia

Kegunaan topikal: Ulser, wounds, sikatris stlh operasi

Etnobotanical Time-line

Tahun Nama Produk Negara

1968 TECA (Like Madecassol), Oitment 1% Portugal

1969 Madecassol, Krim 1%, tablet Belgia

1973 TECA, tablet Portugal

1974 TECA (Madecassol), Tablet Perancis

1975 TECA, Cream 1%, Powder 2% Perancis

1976 TECA, steril Perancis

1982 TECA (Centellase), Tablet Italy

1997 Bilim (like Madecassol), Oitment 1% Greece

Produk Development Time-line

Kandungan Senyawa Aktif pada Pegagan

Elephantopus scaber L.(Tapak Liman)

Kabeer and Prathapan, 2014

Kegunaan Tradisional

Kajian Bioaktivitas dan Farmakologi

Produk/ Sediaan Elephantopus scaber L.

PengembanganTumbuhan Obatdi Industri

From; Trade in Medicinal Plant, FAO-Rome, 2004

Added Value Phytomedicine

Daun Gambir

Ekstrak gambir

Ekstrak Terpurifikasi

Nano/Mikro katekin

Marker

Rp 800/kg

Rp 30-45 rb/kg

Rp 350-500 rb/ Kg

???

220 USD/ 25 mg

Uncaria gambier Robx