4. tw- sediaan btk obat (2)
TRANSCRIPT
SELAMAT PAGI
RM. Teguh Wahjudi dr,MS,AFK
BENTUK SEDIAAN OBATDISPENSING FORMS OF DRUG
Dr.M.Teguh Wahjudi MS,AFK,PKK
BENTUK SEDIAAN OBAT
• BENTUK CAIR ( LIQUID )
• BENTUK SETENGAH PADAT ( SEMI LIQUID)
• BENTUK PADAT (SOLID )
BENTUK OBAT PADAT
• Serbuk (pulvis).
• Serbuk terbagi (pulveres).
• Tablet .
• Kapsul
• Sapo
• Emplastrum
• Susuk
BENTUK OBAT SETENGAH PADAT
• Salep
• Cream
• Pasta
• Suppositoria
BENTUK OBAT CAIR
• Solutio
• Mixtura
• Mixtura Agitanda
• Suspensi
• Emulsi
• Saturatio
• Guttae
• Galenical
• Nebula /Aerosol
• Injectio
KRITERIA MEMILIH BENTUK OBAT
1.FAKTOR OBAT : Fisik obat. Kimia obat. Onset & duration of action Rasa pahit. Iritasi lambung.
2.FAKTOR PENDERITA : Anak – dewasa – tua Compos mentis - coma
BENTUK OBAT CAIR
SOLUTIO ( LARUTAN )
ZAT PADAT DALAM ZAT CAIR – LARUT –TIDAK ADA ENDAPAN – JERNIH - HOMOGEN
PELARUT :
-AIR
-ALKOHOL
-ETHER
-PROPPYLEN GLYCOL
-MINYAK
-PARAFIN LIQUIDUM
-GLYSERIN
KELARUTAN :
-SOLUTE
-SOLVEN
-TEMPERATUR
-pH
R/ Acidi Borici 3 6
Aquadest ad 100ml 200 ml
S Boorwater
---------- paraf
R/ Acidi Borici 3% 3%
Aquadest ad 100ml 200 ml
S Boorwater
---------- paraf
R/ Jodii 2
Natrii Jodid 2,5
Spir 50% ad 100ml
rec.par
S u.e.
---------- paraf
R/ Solutio Jodii spir. 2% 100 ml
rec.par
S u.e
---------- paraf
R/ Jodium tincture 100 ml
rec. par
S u.e
---------- paraf
R/ Jodii 0,50
Kalii Jodii 0,100
Aqua ad 25 ml
f.l.a Sol
S t.dd gtt XV
------ paraf
R/ Solutio Lugolli 25 ml
S 3 dd. gtt XV
------ paraf
R/ Succus liquiritiae 5
Ammonii Chlorid 3
Sol.Ammonii spir. Anis 3
Aquadest ad 150 ml
S 3 dd C I
------ paraf
R/ Potio Nigra contra tussim 150 ml
S 3 dd. C. I
------------------ paraf
R/ O.B.H 150 ml
S 3 dd. C.I
------ paraf
Sasa tdd :
-Ammonia
-Ammon. Carbonat
-Various oils
-Spir. dil
R/ Zinci Chlorid 1
Kalii et . Alum. Sulfat 1
Acid Salicylic 0,300
Ol. Menthe Pip gtt II
Aqua ad 300ml
Filtra
S garg. 3 dd
------------ ---------- paraf
R/ Garg Kan 300 ml
S garg. 3 dd
------ ---- -------- paraf
R/ Ascal 10
Natrii Bromidi 5
Aquadest ad 300 ml
S 3 dd C.I pc prn
-------- ---- paraf
MIXTURA
• HCl + air
• Alkohol + air :
70% Spir. Dil
95% - 96% Spir. Fortior.
• Homogen – tidak ada endapan – tercampur secara molekuler
R/ Methyl Salicylic 20
Ol.Cayuputi 20
Chloroform 20
Inf. Hioscyami oleos 20
S a.u.e
------------- paraf
R/ Gandapura 80 ml
S u.e
---------------- paraf
R/ Sasa 2 ml
Syr. Simplex 10 ml
Ol. Menthe pip gtt I
Aquadest ad 100 ml
S 4-6 dd Cth I
------------- paraf
R/ Potio Alba contra tussim 100 ml
S 4-6 dd Cth I
------ ------- paraf
R/ O .B .P 100 ml
S 4-6 dd Cth I
------ ------- paraf
MIXTURA AGITANDA
R/ Acid Salicylic 1
Zinci Oxyde 10
Talc.Venet 10
Amyl.Orizae 10
Alcohol 90% ad 200 ml
S u.e
------ paraf
R/ Calamine 8
Zinci Oxyde 8
Glycerin 5 ml
Aqua Rosae ad 100 ml
S u.e
------ paraf
SUSPENSIO
DEFINISI :
SUSPENSATOR : A.ALAMI B.SYNTHETIC
SUSPENSATOR
ALAMI
• GUMMI ARAB : Pulv.
Solutio
Mucilago• TRAGACANTH :Sol.
Mucilago• AMYLUM :Mucilago• AGAR• DLL
SYNTHETIC
• CMC• Bentonit• Tween
R/ Paracetamol 2880 mg Syr. Simplex 15% CMC 1,5 % Aqua ad 120 ml f.l.a susp S 3 dd cth II ------ paraf
R/ Ampicillin 50 mg Syr simplex Orange gtt qs CMC 1,5 % Aqua ad 60 ml m.f.l.a susp S 3 dd cth I ----- paraf
R/ Tetracycline 2,3 CMC Na 1% Sol. Sorbitol 60% 20 ml Saccharin Na 0,100 Sir.Simplex 20 ml Glycerin 3,5ml Corrigens (orange) gtt qs Aquadest ad 100 ml m f l a susp S . . . . .. ----- paraf
R/ Syrop Tetracycline …ml S 2 dd cth I ----- paraf
R/ Syrop Tetracycline ….ml S . . . . . . . . . ----- paraf
R/ Magnesium hydroxyde 2400 mg Al. hydroxyde 2400 mg Simethicon 240 mg Gummi Arab 2 % Ol. Menthe pip gtt II Aquadest ad 60 ml m f l a susp S loco Mylanta susp 3 – 4 dd cthI – cth II ----- paraf
R/ Trimetoprim 480 mg Sulfametoxazole 2400 mg Sir. Simplex 10 % – 20 % P.G.A 2 % Strawberry qs Aquadest ad 60 ml m f l a susp S Susp Cotrimoxazole 2 dd cth I ------ paraf
R/ Sulfasomidin 10 C M C 1 % Saccharosa 30 % Methyl hydroxy benzoat 0,015 % Propyl hydroxy benzoat 0,015 % Sol.Amaranth 1 % gtt V Aquadest ad 100 ml S . . . . . ----- paraf
R/ Sirop Elkosin 100 ml S . . . . . . . . ----- paraf
R/ Sulfadiazine Natrii bicarb. aa 10 Sir. Aurantii 30 Sol. Gumoss ad 300 ml ∫ 3 dd C I ----- paraf
R/ Sulfadiazine 5 S a s a 1 Calcii lactas 4 Sir. Simplex 10 Pulv. Gummos 2 Aquadest ad 150 ∫ K S H D ------- paraf
EMULSIOEmulgator ~ Suspensator
R/ Ol. Zecoris aselli 40 Ol. Cinnamomi 0,100 Pulv. Gi Arab 15 Natr Hypophospis 0,500 Calc Hypophospis 0,500 Aquadest 20 Glyserin 10 Aquadest 14 m f l a emuls ∫ loco Scott’s emulsion ----- paraf
R/ Benzylis Benzoas 25 Triethanol amine 1 Acid Stearinic 5 Aqua ad 100 ml m f l a emulsi S u.e ----- paraf
R/ B.B.E 25 % 100 ml S u.e ----- paraf
GALENICALS
PELARUT ALKOHOL → TINCTURE AIR + ALKOHOL/ETHER → EXTRACT AIR 90OC / 15’ → INFUSUM AIR 90oC / 30’ → DECOCTUM
PREPARAT GALENIK
1.DENGAN PEMANASAN
90oC 15’ : INFUSUM 30’ : DECOCTUM
2.TANPA PEMANASAN ( SUHU KAMAR) * 4 – 5 hari maceratio * Diulang / remaceratio percolatio
Hasil maceratio/ remaceratio : Extractum Tinctura
Extract : CAIR : Extract Secale Cornuiti KENTAL : Extract Belladona KERING : Extract Opii
Tincture TOXIC : Kadar 10% Tinctura Opii Tinctura Belladona Tinctura Digitalis
NON TOXIC : Kadar 20% Tinctura Valeriane
Infusum
R/ Folia Piperie betle 20 Natrii Chlorid 4 Aqua qs f. Infus 200 ml S garg. 4 dd ----- paraf
R/ Folia Digitalis 15 g Aqua 900 ml Alkohol 100 ml Spirit Cinnamomi 5 ml f. Infus 1000 ml S 3 dd cth II ----- paraf
NEBULA /AEROSOL
Gas : -dichloro difluoro methane -trichloro monofluoro methane -dichloro tetrafluoro methane
Nama dagang : -Freon -Genetron -Isotron -Ucon
GUTTAE
1 ml H2O ~ 1 g H2O = 20 tetes
R/ Zinci Sulfate 0,25 % Aqua ad 10 ml f.Steril S 3 dd gtt II OD/OS ----- paraf
SIRUPUS
R/ Sukrose 65 % Aqua ad 1000 ml ∫ sirupus simplex ---- paraf
SATURATIOR/ Acid Citric 2,5 Aqua 25 Spir Citri 2,5 Sir.Simplex 12,5 Natr. Bicarbonat 3 Aqua 55 ∫ Potio Riveri ----- paraf
Injectio / Suntik
Tujuan, Keuntungan, KerugianSyarat, Bentuk, Wadah
TERIMA KASIH