3.siklus menstruasi
DESCRIPTION
semoga bermanfaatTRANSCRIPT
SIKLUS MENSTRUASIYONAS HADISUBROTO
PENDAHULUAN
Menstruasi merupakan hasil kerjasama yang sangat rapi dan baku dari poros H-H-O (Hipotalamus-Hipofisis-Ovarium)
Triono Soendoro 12503
Hipotalamus
Foliculogenesis &
Oogenesis
E & P
FSH & LH
Steroidogenesis
GnRH
Pulsatile Secretion
In
“Critical Range”
Hipofisis
Ovarium
MenstruationSingle
ovulation
Ultra Short FB
(Down Reg.)
Short F.B
Long F.B
Triono Soendoro 12503
10
9
8
7
6
5
4
3
2
1
FSH
LH
Estradiol
FSH-Gran. Cell Prolif.-Arom. Androg – E2-FSH & E2 R/FSH in Gran. Cell-Stim. Inhibin. Act. ProdLH (Theca Cell)- Synth. Androg
LH surge-Menghambat Oosit Maturation Inhibitor(OMI)-Synth. Prostaglandin (PG)-Elevated P + : -Plasminogen Plasmin -FSH—Surge FSH Surge : - Proteolytic enzym activity - FSH + E2 R/ LH in gran cells
P
FSH & LH
LH Maintain - Corpus luteum -Vascul.-Steroidogenesis
Progesterone
17-OHP Ng/ml.Physiology of Ovulation (Menstruation)
2 4 6 8 10 12 14 16 18 20 22 24 26 28
Teori Dua Sel
Fase Proliferasi
Estrogen meningkat feedback negatif FSH menurun Teori threshold-window Folikel dominan
Estrogen terus meningkat >200 pg/ml selama 50 jam LH surge 36-48 jam kemudian terjadi Ovulasi
Dominasi estrogen endometrium pada fase proliferasi
FSH: Teori Threshold-Window
window
recruitment
threshold
selection dominance
FS
H le
vel
Fo
llicl
e si
ze
luteo-follicular transition
Triono Soendoro 12503
10
9
8
7
6
5
4
3
2
1
FSH
LH
Estradiol
LH
FSH
Estradiol
17-OH-Progesterone
Pogesterone
FSH-Gran. Cell Prolif.-Arom. Androg – E2-FSH & E2 R/FSH in Gran. Cell-Stim. Inhibin. Act. ProdLH (Theca Cell)- Synth. Androg
LH surge-Menghambat Oosit Maturation Inhibitor(OMI)-Synth. Prostaglandin (PG)-Elevated P + : -Plasminogen Plasmin -FSH—Surge FSH Surge : - Proteolytic enzym activity - FSH + E2 R/ LH in gran cells
P
FSH & LH
LH Maintain - Corpus luteum -Vascul.-Steroidogenesis
Progesterone
17-OHP Ng/ml.Physiology of Ovulation (Menstruation)
2 4 6 8 10 12 14 16 18 20 22 24 26 28
Fase Sekresi
Pasca Ovulasi Corpus Luteum menghasilkan Progesteron
Dominasi Progesteron endometrium pada fase sekresi
Triono Soendoro 12503
10
9
8
7
6
5
4
3
2
1
FSH
LH
Estradiol
LH
FSH
Estradiol
17-OH-Progesterone
Pogesterone
LH Progestrerone
FSH
Estradiol
LH
17-OH-Progesterone
FSH-Gran. Cell Prolif.-Arom. Androg – E2-FSH & E2 R/FSH in Gran. Cell-Stim. Inhibin. Act. ProdLH (Theca Cell)- Synth. Androg
LH surge-Menghambat Oosit Maturation Inhibitor(OMI)-Synth. Prostaglandin (PG)-Elevated P + : -Plasminogen Plasmin -FSH—Surge FSH Surge : - Proteolytic enzym activity - FSH + E2 R/ LH in gran cells
P
FSH & LH
LH Maintain - Corpus luteum -Vascul.-Steroidogenesis
Progesterone
17-OHP Ng/ml.Physiology of Ovulation (Menstruation)
2 4 6 8 10 12 14 16 18 20 22 24 26 28
OV
Fase Mentruasi
Apabila tidak ada kehamilan Corpus Luteum akan atresia Estrogen dan Progesteron menurun
Estrogen dan Progesteron menurun berakibat : endometrium pada fase menstruasi
feed back positif FSH dan LH (mulai siklus menstruasi yang baru)
TERIMA KASIH